DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-m and Tnn

DIOPT Version :10

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:NP_808507.2 Gene:Tnn / 329278 MGIID:2665790 Length:1560 Species:Mus musculus


Alignment Length:1864 Identity:341/1864 - (18%)
Similarity:568/1864 - (30%) Gaps:674/1864 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1114 NGECICNPGWKGKECSL--RHD--------ECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCP 1168
            :|..:..||..|:|.::  ||:        .|::||          ..|.:.....|..||:...
Mouse    68 DGTSLLAPGEDGEEQNIIFRHNIRLQTPQKNCDLAD----------SVQDLLARMKKLEEEMAEL 122

  Fly  1169 HPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCS 1233
            ...|:.:..|                    |.|......|||||||..:|.:|.|:..|.|.||.
Mouse   123 KEQCNTNRCC--------------------QGAADLSRHCSGHGTFLPETCSCHCDQGWEGADCD 167

  Fly  1234 KELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEG 1298
            :..|...|..||||....|.||..:.|..|....|...|:.||.|..|.|.|...:..:.|:.:.
Mouse   168 QPTCPGACNGHGRCVDGQCVCDAPYVGVDCAYAACPQDCSGHGVCVQGVCQCHEDFTAEDCSEQR 232

  Fly  1299 CPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVC 1363
            ||..|:|:|.|...     ||.|..|:.||||                                 
Mouse   233 CPGDCSGNGFCDTG-----ECYCEMGFTGPDC--------------------------------- 259

  Fly  1364 KTSQLCVSAPKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASR-S 1427
              ||  |.||:.:. ||:....::..|:        :.||..:|..|         :|:...: .
Mouse   260 --SQ--VVAPQGLQ-LLKSTENSLLVSW--------EPSSEVDYYLL---------SYYPLGKEQ 302

  Fly  1428 AVIRGRV--------VTSLGMG------LVGVRVSTTTLLEGFTLTRDDGWFDLMVNGGGAVTLQ 1478
            |..:.||        :|.|..|      |..|:...::..:....|.     ||.|.|...|.  
Mouse   303 ATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSSPQHLLATT-----DLAVVGTAWVN-- 360

  Fly  1479 FGRAPFRPQSRIVQVPW-NEVVIIDLVVMSMSEEKGLAVTTTHTCFAHD----YDLMKPVVLASW 1538
                  ......:.|.| |.:..:|...:......|..||......:.|    ||:.        
Mouse   361 ------EETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDIT-------- 411

  Fly  1539 KHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIH 1603
              |.|                      |||...:.                    |:|       
Mouse   412 --GLQ----------------------PGTEYKIT--------------------VVP------- 425

  Fly  1604 LRITIEG--ILFERIFEADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYT-DCTDIVWDIQT 1665
            :|..:||  ||.....|.|                    |.|..|..   |.| |...:.||...
Mouse   426 IRGDLEGKPILLNGRTEID--------------------GPTNVVTN---QVTEDTASVSWDPVR 467

  Fly  1666 TKLSGHDMSISEVGGWNLDIHHRYNFHEG-----ILQKGDGSNIYLRNKPRIILTTMGDGHQRPL 1725
            ..:..:.:              ||...:|     .:.|...|.:....||       |:.: :..
Mouse   468 ADIDKYVV--------------RYIAPDGETKEKAVPKDQSSTVLTGLKP-------GEAY-KVF 510

  Fly  1726 ECPDCDGQATKQRLLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKLNATRVSY------- 1783
            ...:...|.:|:.....:....:|:            .::||.     |..|:..||:       
Mouse   511 VWAERGNQGSKKADTKALTEIDSPE------------NLVTDR-----VTENSLSVSWDPVEADI 558

  Fly  1784 -RYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQPELNWEAVVGSGERCLPGDE------AHCG 1841
             ||.::.:.:||       |:.|:...:|........|:            ||.|      |..|
Mouse   559 DRYVVSYTSVDG-------ETKQVPVKKDQRSTVLTGLS------------PGVEYKVYVWAEKG 604

  Fly  1842 DGALAKDAKLAYPKG-------------------IAISSDNILYFADGTNIRMVDRDG------- 1880
            |    :::|.|..|.                   :::|.|.:....|...:.....||       
Mouse   605 D----RESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGETREVPV 665

  Fly  1881 -------IVSTLIGNHMHKSH-WKPIPCEGTLKLEEMHLRWPTEL-------AVSPMDNTLHI-- 1928
                   :::.|.....:|.| |..   :||.:..:.:.:.||::       .....:.||.:  
Mouse   666 PKEKSSTVLTGLRPGVEYKVHVWAQ---KGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSW 727

  Fly  1929 ------IDDHMILRMTPDGRVR-----------VISG-RP--------------LHCATASTAYD 1961
                  ||.:|:...:|||..:           |:.| ||              .....|:|...
Mouse   728 DPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKANTKAP 792

  Fly  1962 TDLATHATLVMPQ------SIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESKCNCLE 2020
            ||:.:...||..|      ::::.|:      |:|..|. .||....||....|...:.:.:.:.
Mouse   793 TDIDSPKNLVTEQVTESTATVSWDPV------EADIDRY-VVRYTSVDGETREFLVGKDQTSTVL 850

  Fly  2021 RG--------CDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEASPSRE 2077
            .|        .|.: |:.....|.|.:|.|...:....:: :.||......||.....||...|.
Mouse   851 TGMRPGVEYQVDVW-AQKGTQESRKTSTKAPTDIDGPKNL-VTDQVTETTLSVSWDPVEADIDRY 913

  Fly  2078 YEIY-APDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFLLRDYT 2141
            ...| :||                     |||.     .|..|..|.|||.......|....|..
Mouse   914 MVRYTSPD---------------------GETK-----EVPVSKDKSSTVLRGLRPGVEYKVDVW 952

  Fly  2142 SQVNSIENTKGQKCRLRMTRMKMLHELSTP------------------------DNYNVTYEYHG 2182
            :|..:.::        |....|...::.:|                        |.|.|.|    
Mouse   953 AQKGAQDS--------RKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRY---- 1005

  Fly  2183 PTGLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDL-SVKGAQVKVSENAQKEMSLLI 2246
                  |..|...:.::...::...:.:.:.|.   :|...:: :.|||  :.|:.|..|....|
Mouse  1006 ------TSADGESKEFLIGKEQRSTVLTGLRPG---VEYKVEVWAQKGA--RESKKANTEGHTDI 1059

  Fly  2247 QGATVIVRNGAAESRTTVDMDGSTTSITPWGHNLQMEVAPYTILAEQSPLLGESYPVPA---KQR 2308
            .....:|.|...|:..|:..|           .:|.::..|.:....:.  ||:..:|.   |..
Mouse  1060 DSPKNLVTNQVTENTATISWD-----------PVQADIDRYMVRYTSAD--GETREIPVRKEKSS 1111

  Fly  2309 TEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVM 2373
            |.:.| |....|:...|..|:..:..|::|  .:..||:        |:...|..:|.|::...:
Mouse  1112 TVLTG-LRPGVEYTVQVWAQKGARESKKAK--TKAPTEI--------DSPKNLVTNRVTENTATI 1165

  Fly  2374 VDDKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIK 2438
            ..|.   :....||..  :.:....|:..::.:..|:...:                   |..:|
Mouse  1166 SWDP---VRANIDRYM--VRYTSADGETKEIPVSKDQSSTI-------------------LTGLK 1206

  Fly  2439 YGDGSTM-VYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGFFKY 2502
            .|...|: |:|.|   |:...|..            |..||..:..||                 
Mouse  1207 PGMEYTIHVWAQK---GARESKKA------------DTKALTEIDPPR----------------- 1239

  Fly  2503 QYYSPINRHPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVK 2567
                  |..||.:.::  |.:|..:.|.                   |.:.....|||.....||
Mouse  1240 ------NLRPFGVTHS--GGVLTWLPPS-------------------AQIDGYILTYQFPNGTVK 1277

  Fly  2568 SVEVQ--EPGFELRREFKYHAGILKDEKLRFGSKNSLASARYKYAYDGNARLSGIEMAIDDKELP 2630
            .||:.  :..|||:   ....|:.....|              .|:.||.|...:...:...:  
Mouse  1278 EVELPRGQQRFELQ---DLEQGVTYPVSL--------------VAFKGNQRSRTVSTTLSTVD-- 1323

  Fly  2631 TTRYKYSQNLGQLEVVQDLKITRNAFNRTVIQDSAK--QFFAIVDYDQHGRVKSVLMNVKNIDVF 2693
             .|:.:..:..|::  |:.......:...:..|:::  |.:..:|.|..|.:.....|...:|.|
Mouse  1324 -ARFPHPSDCSQVQ--QNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFF 1385

  Fly  2694 R-----------------LELD------------YDLRNRIKS--------------------QK 2709
            :                 |.||            |::|..:::                    .|
Mouse  1386 KRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNESAYAVYDFFQVASSKERYK 1450

  Fly  2710 TTFG--RSTAFDKINYNADGHVVEVLGTNNWKYLFDENGNTVGV 2751
            .:.|  |.||.|.:.|:           |.||:...:..|.:.:
Mouse  1451 LSVGKYRGTAGDALTYH-----------NGWKFTTFDRDNDIAL 1483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 EGF_Tenascin 1071..1098 CDD:480934
EGF_2 1139..1162 CDD:400365 3/22 (14%)
DUF5885 <1181..1229 CDD:437064 13/47 (28%)
EGF_2 1272..1294 CDD:400365 7/21 (33%)
acid_disulf_rpt 1337..1363 CDD:411265 0/25 (0%)
NHL 1750..2065 CDD:302697 73/417 (18%)
NHL repeat 1784..1830 CDD:271323 8/45 (18%)
NHL repeat 1854..1888 CDD:271323 7/66 (11%)
NHL repeat 1911..1950 CDD:271323 12/65 (18%)
NHL repeat 1972..2005 CDD:271323 8/38 (21%)
NHL repeat 2039..2065 CDD:271323 4/25 (16%)
RHS_repeat 2183..2217 CDD:461685 3/33 (9%)
RhsA <2248..2980 CDD:442442 94/563 (17%)
Tox-GHH 3191..3268 CDD:464783
TnnNP_808507.2 EGF_2 142..166 CDD:400365 12/23 (52%)
C_rich_MXAN6577 <171..>237 CDD:469225 22/65 (34%)
EGF_Tenascin 171..198 CDD:480934 10/26 (38%)
EGF_2 236..259 CDD:400365 10/27 (37%)
fn3 264..332 CDD:394996 16/85 (19%)
fn3 359..434 CDD:394996 21/141 (15%)
FN3 444..529 CDD:238020 19/129 (15%)
FN3 532..608 CDD:214495 21/115 (18%)
FN3 620..696 CDD:214495 11/78 (14%)
fn3 710..781 CDD:394996 12/70 (17%)
fn3 796..875 CDD:394996 16/86 (19%)
FN3 857..1371 CDD:442628 120/693 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..888 4/19 (21%)
fn3 972..1049 CDD:394996 12/91 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1044..1063 6/20 (30%)
FN3 1060..1136 CDD:214495 17/89 (19%)
FReD 1327..1539 CDD:238040 26/170 (15%)
Blue background indicates that the domain is not in the aligned region.

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