DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-m and shf

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	82/365 - (22%)
Similarity:	125/365 - (34%)	Gaps:	96/365 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   957 KLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRRNALPTHTQYHFKEVLSGFSASTR 1021
            ::|.:::..:.:|.....||..||.|.:.         .|||...     |.|..:.   :....
  Fly   149 RVTNDLRDTTLYNFLVIPSEVNYVNFTWK---------SGRRKYF-----YDFDRLQ---TMDES 196

  Fly  1022 TARAAHLSITREVTRYMEPGHWFVSLYNDDGDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLG-- 1084
            ..:|..|||.:......|..::.:.|                      .|....||.....:|
  Fly   197 ILKAPTLSIRKSGRIPQEQKNFSIFL----------------------PCTGNSSGTASFNVGLK 239

  Fly  1085 -HCQCNPGFGGDDCSESVCPVL------CSQHGEY----TNGECICNPGWKGKECSLRHDECEVA 1138
             ..:.|....|       .|:.      |:..|.|    :|...:........||||:
  Fly   240 IQTRHNKPLSG-------TPIRLNFKKECAHRGVYDIDASNPTSLTTLQAPDPECSLK------- 290

  Fly  1139 DCSGHGHCVSGK-CQCMRGYKGKFCEEVDCPHPNCSGHGFC-ADGTCICKKGWKGPDCATMDQDA 1201
             |..:|:|.... |:|..||.|::||...| .|.|...|.| |...|.|.:|::|..|     :.
  Fly   291 -CGKNGYCNEHHICKCNVGYTGQYCETAFC-FPQCLNGGNCTAPSVCTCPEGYQGTQC-----EG 348

  Fly  1202 LQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEG-DACACDPEWGGEYC-- 1263
            ..|...|...|.. :....|.|...:.|..|....|.:.|...|||.| :.|.|.....|::|
  Fly   349 GICKDKCLNGGKC-IQKDKCQCSKGYYGLRCEYSKCVIPCKNEGRCIGNNLCRCPNGLRGDHCEI 412

  Fly  1264 ---NTRLCDVRCNEHGQCKNGTCL------CVTGWNGKHC 1294
               ...:|        :|:||||:      |..|:.|:||
  Fly   413 GRKQRSIC--------KCRNGTCVSHKHCKCHPGFYGRHC 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	36/143 (25%)
		CRD2	1106..1151	CDD:276900	11/49 (22%)
		EGF_2	1139..1162	CDD:285248	8/23 (35%)
		Keratin_B2	1162..1330	CDD:279797	41/146 (28%)
		EGF_2	1167..1194	CDD:285248	10/27 (37%)
		DUF3844	1171..>1235	CDD:289707	16/64 (25%)
		EGF_2	<1272..1294	CDD:285248	8/27 (30%)
		NHL	1750..2065	CDD:302697
		NHL repeat	1784..1830	CDD:271320
		NHL repeat	1854..1888	CDD:271320
		NHL repeat	1911..1950	CDD:271320
		NHL repeat	1972..2005	CDD:271320
		NHL repeat	2039..2065	CDD:271320
		RHS_repeat	2183..2218	CDD:283287
		RhsA	2347..3020	CDD:225750
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
shf	NP_001284963.1	WIF	137..258	CDD:280237	25/154 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810