Protein Alignment Ten-m and Tnn

DIOPT Version :10

• Sequence 1: NP_001262211.1
• Gene: Ten-m / 40464
• FlyBaseID: FBgn0004449
• Length: 3349
• Species: Drosophila melanogaster
• Sequence 2: NP_001100659.2
• Gene: Tnn / 304913
• RGDID: 1306002
• Length: 1562
• Species: Rattus norvegicus
• Alignment Length: 1862
• Identity: 352/1862 - (18%)
• Similarity: 571/1862 - (30%)
• Gaps: 669/1862 - (35%)

  Fly  1114 NGECICNPGWKGKECSL--RHD--------ECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCP 1168
            :|..:..||..|:|.::  ||:        .||:||          ..|.:.....|..||:...
  Rat    68 DGTSLLVPGEDGEEQNIIFRHNIRLQTPQKNCELAD----------SVQDLLARVKKLEEEMAEL 122

  Fly  1169 HPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCS 1233
            ...||....|                    |.|......|||||||..:|.:|.|:..|.|.||.
  Rat   123 KEQCSTSRCC--------------------QGAADLSRHCSGHGTFFAETCSCHCDQGWEGADCE 167

  Fly  1234 KELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEG 1298
            :..|...|..||||....|.||..:.|..|....|...|:.||.|..|.|.|...:..:.|:.:.
  Rat   168 QPTCPGACSGHGRCVDGQCVCDQPYVGVDCAYAACPQDCSGHGVCVRGVCQCHKDFTAEDCSEQR 232

  Fly  1299 CPNSCAGHGQCRVSGEGQWECRCYEGWDGPDC-------GIALELNCGDSKDNDKDGLVDCEDPE 1356
            ||..|:|:|.|...     ||.|..|:.||||       |:.|      .|..:...||..| |.
  Rat   233 CPGDCSGNGFCDTG-----ECYCEMGFTGPDCSQVVAPQGLQL------LKSTENSLLVSWE-PS 285

  Fly  1357 CCASHVC----------KTSQLCVSAPKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLE 1411
            ....|..          .|.|  |..||       :|............|:::   :|:|..|
  Rat   286 SEVDHYLLSYYPLGKEQATKQ--VRVPK-------EQHTYDITGLLPGTKYIV---TLRNVKK-- 336

  Fly  1412 TFNESIFWNYFNASRSAVIRGRVVTSLGMGLVG---VRVSTTTLLEGFTLTRDDGWFDLMVNGGG 1473
                       :.|.|.   ..::.:..:.:||   |...|.|.|:
  Rat   337 -----------DISSSP---QHLLATTDLAVVGTAWVNEETETSLD------------------- 368

  Fly  1474 AVTLQFGRAPFRPQSRIVQVPW-NEVVIIDLVVMSMSEEKGLAVTTTHTCFAHD----YDLMKPV 1533
                               |.| |.:..:|...:......|..||......:.|    ||:.
  Rat   369 -------------------VEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDIT--- 411

  Fly  1534 VLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTS 1598
                   |.|                      |||...:.                    |:|
  Rat   412 -------GLQ----------------------PGTEYKIT--------------------VVP-- 425

  Fly  1599 LHLIHLRITIEG--ILFERIFEADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYT-DCTDIV 1660
                 :|..:||  ||.....|.|                    |.|..|..   |.| |...:.
  Rat   426 -----IRGDLEGKPILLNGRTEID--------------------GPTNVVTN---QVTEDTASVS 462

  Fly  1661 WDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEG-----ILQKGDGSNIYLRNKPRIILTTMGDG 1720
            ||.....:..:.:              ||..|:|     .:.|...|.:....||       |:.
  Rat   463 WDPVRADIDKYVV--------------RYISHDGETKEKAVPKDQSSTVLTGLKP-------GEA 506

  Fly  1721 HQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKLNATRVSY-- 1783
            : :.....:...|.:|:.....:....:|:            .::||.     |..|:..||:
  Rat   507 Y-KVFVWAERGNQGSKKADTKALTEIDSPE------------NLVTDR-----VTENSLSVSWDP 553

  Fly  1784 ------RYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQPELNWEAVVGSGERCLPGDE----- 1837
                  ||.::.:.:||       |:.|:...:|.:......|:            ||.|
  Rat   554 VEAEIDRYVVSYTSVDG-------ETKQVPVRKDQSSTVLTGLS------------PGVEYKVYV 599

  Fly  1838 -AHCGDGALAKDAKLAYPKG-------------------IAISSDNILYFADGTNIRMVDRDG-- 1880
             |..||    :::|.|..|.                   :::|.|.:....|...:.....||
  Rat   600 WAEKGD----RESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGET 660

  Fly  1881 ------------IVSTLIGNHMHKSH-WKPIPCEGTLKLEEMHLRWPTEL-------AVSPMDNT 1925
                        :::.|.....:|.| |..   :||.:..:.:.:.||::       .....:.|
  Rat   661 REVPVPKEKSSTVLTGLRPGMEYKVHVWAQ---KGTQESRKANTKAPTDIDGPKNLVTDQVTETT 722

  Fly  1926 LHI--------IDDHMILRMTPDGRVR-----------VISG-RP--------------LHCATA 1956
            |.:        ||.:|:...:|||..:           |:.| ||              .....|
  Rat   723 LSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKA 787

  Fly  1957 STAYDTDLATHATLVMPQ------SIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESK 2015
            :|...||:.:...||..|      ::::.|:      |:|..|. .||....||....|...:.:
  Rat   788 NTKAPTDIDSPKNLVTEQVTESTATVSWDPV------EADIDRY-VVRYTSVDGETREFLVGKDQ 845

  Fly  2016 CNCLERG--------CDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEA 2072
            .:.:..|        .|.: |:.....|.|.:|.|...:....:: :.||......||.....||
  Rat   846 TSTILTGMKPGVEYQVDVW-AQKGTRESRKTSTKAPTDIDGPKNL-VTDQVTETTLSVSWDPVEA 908

  Fly  2073 SPSREYEIY-APDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFL 2136
            ...|....| :||                     |||.     .|..|..|.|||.......|..
  Rat   909 DIDRYMVRYTSPD---------------------GETK-----EVPVSKDKSSTVLRGLRPGVEY 947

  Fly  2137 LRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTP------------------------DNYNVT 2177
            ..|..:|..:.::        |....|...::.:|                        |.|.|.
  Rat   948 KVDVWAQKGAQDS--------RKANTKAPTDIDSPKNLAINQVTETTLSVSWDPVQADIDRYVVR 1004

  Fly  2178 YEYHGPTGLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDL-SVKGAQVKVSENAQKE 2241
            |          |..|...:.::...::...:.:.:.|.   :|...:: :.|||  :.|:.|..:
  Rat  1005 Y----------TSADGESKEFLIGKEQRSTVLTGLRPG---VEYKVEVWAQKGA--RESKKANTK 1054

  Fly  2242 MSLLIQGATVIVRNGAAESRTTVDMDGSTTSITPWGHNLQMEVAPYTILAEQSPLLGESYPVPA- 2305
            ....|.....:|.|...|:..|:..|           .:|.::..|.:....:.  ||:..||.
  Rat  1055 GHTDIDSPKNLVTNQVTENTATISWD-----------PVQADIDRYMVRYTSAD--GETREVPVR 1106

  Fly  2306 --KQRTEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQ 2368
              |..|.:.| |....|:...|..|:..:..:::|  .:..||:        |:...|..:|.|:
  Rat  1107 KEKSSTVLTG-LRPGVEYTVQVWAQKGARESRKAK--TKAPTEI--------DSPKNLVTNRVTE 1160

  Fly  2369 SVVVMVDDKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGR 2433
            :...:..|.   :..|.||..  :.:....|:..:|.:..|:...:
  Rat  1161 NTATISWDP---VRATIDRYM--VRYTSADGETKEVPVSKDQSSTI------------------- 1201

  Fly  2434 LNEIKYGDGSTM-VYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSL 2497
            |..:|.|...|: |:|.|   |:...|..            |..||..:..|:
  Rat  1202 LTGLKPGMEYTIHVWAQK---GARESKKA------------DTKALTEIDPPK------------ 1239

  Fly  2498 GFFKYQYYSPINRHPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDT 2562
                       |..||.:             .|.||.:.::..:|.....||        |||..
  Rat  1240 -----------NFRPFGV-------------THSSGVLTWMPPSAQIDGYIL--------TYQLP 1272

  Fly  2563 TSLVKSVEVQ--EPGFELR---REFKYHAGILK---DEKLRFGSKN-SLASARYKYAYD------ 2612
            ..::|.||:|  :..|||:   :...|...::.   :::.|..|.. |...||:.:..|
  Rat  1273 NGILKEVELQRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRSVSTTLSTVDARFPHPSDCSQVQQ 1337

  Fly  2613 -GNARLSGIEMAI--DDKELPTTRY------------KYSQNLGQLEVVQDLKITRNAFNRTVIQ 2662
             .||..||:....  .|...|...|            ...:|.|||:..:..:.....|.
  Rat  1338 NTNAAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFG----- 1397

  Fly  2663 DSAKQFFAIVDYDQHGRVKSVLMNVKNIDVFRLELDYDLRN------------RIKSQKTTFG-- 2713
            |..|:|:..:|         .|.|:......|.|:..||:.            ::.|.|..:.
  Rat  1398 DPMKEFWLGLD---------KLHNLTTGTTTRYEVRADLQTANESAYAVYDFFQVASSKERYKLS 1453

  Fly  2714 ----RSTAFDKINYNADGHVVEVLGTNNWKYLFDENGNTVGV 2751
                |.||.|.:.|:           |.||:...:..|.:.:
  Rat  1454 VGKYRGTAGDALTYH-----------NGWKFTTFDRDNDIAL 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	EGF_Tenascin	1071..1098	CDD:480934
		EGF_2	1139..1162	CDD:400365	3/22 (14%)
		DUF5885	<1181..1229	CDD:437064	13/47 (28%)
		EGF_2	1272..1294	CDD:400365	7/21 (33%)
		acid_disulf_rpt	1337..1363	CDD:411265	6/25 (24%)
		NHL	1750..2065	CDD:302697	73/417 (18%)
		NHL repeat	1784..1830	CDD:271323	8/45 (18%)
		NHL repeat	1854..1888	CDD:271323	7/66 (11%)
		NHL repeat	1911..1950	CDD:271323	12/65 (18%)
		NHL repeat	1972..2005	CDD:271323	8/38 (21%)
		NHL repeat	2039..2065	CDD:271323	4/25 (16%)
		RHS_repeat	2183..2217	CDD:461685	3/33 (9%)
		RhsA	<2248..2980	CDD:442442	104/556 (19%)
		Tox-GHH	3191..3268	CDD:464783
Tnn	NP_001100659.2	EGF_2	142..166	CDD:400365	12/23 (52%)
		C_rich_MXAN6577	<171..>237	CDD:469225	22/65 (34%)
		EGF_Tenascin	171..198	CDD:480934	10/26 (38%)
		EGF_2	236..259	CDD:400365	10/27 (37%)
		fn3	264..332	CDD:394996	15/86 (17%)
		fn3	359..434	CDD:394996	24/171 (14%)
		FN3	444..529	CDD:238020	20/129 (16%)
		FN3	532..608	CDD:214495	21/115 (18%)
		FN3	582..1094	CDD:442628	104/599 (17%)
		fn3	972..1049	CDD:394996	12/91 (13%)
		FN3	1060..1136	CDD:214495	18/89 (20%)
		FN3	1148..1224	CDD:214495	19/102 (19%)
		fn3	1236..1309	CDD:394996	21/116 (18%)
		FReD	1327..1540	CDD:238040	34/183 (19%)