Protein Alignment Ten-m and tnn

DIOPT Version :10

• Sequence 1: NP_001262211.1
• Gene: Ten-m / 40464
• FlyBaseID: FBgn0004449
• Length: 3349
• Species: Drosophila melanogaster
• Sequence 2: XP_005171321.1
• Gene: tnn / 30234
• ZFINID: ZDB-GENE-990415-262
• Length: 1020
• Species: Danio rerio
• Alignment Length: 1184
• Identity: 237/1184 - (20%)
• Similarity: 374/1184 - (31%)
• Gaps: 454/1184 - (38%)

  Fly  1178 CADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCG 1242
            ||.|.|   ||..|.|.:            ||||||:..|:.:|.|...|.|.|||...|..:|.
Zfish   119 CAQGCC---KGGAGVDTS------------CSGHGTYQQDSCSCKCNPGWEGPDCSISSCPDECN 168

  Fly  1243 QHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHG 1307
            .:|||....|.|...:.|..|:...|...|.:.|.|.:|.|:|.:|::|:.|:|..|||.|.|:|
Zfish   169 DNGRCVDGRCVCYEGYTGHDCSQLTCPNDCKDKGHCVDGKCVCFSGFSGEDCSIATCPNDCIGNG 233

  Fly  1308 QCRVSGEGQWECRCYEGWDGPDCGIALELNCGDS-----KDNDKDGLVDCEDPECCASHVC---- 1363
            :| |.|    :|.|.||:.|.||.:.|    |..     |..|...||:.|.......::.
Zfish   234 RC-VDG----QCICDEGFFGIDCSMVL----GPKGLRLIKVTDVSLLVEWESVRGAEYYILSYHP 289

  Fly  1364 KTSQLCVSAPKPIDV-------LLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNY 1421
            |.::   .|.|.:.|       |:....|.:|        :::     |.||.:...|
Zfish   290 KGNK---GAIKEVQVENTKNSYLITGLKPGVT--------YIV-----QVYAVIRGIN------- 331

  Fly  1422 FNASRSAVIRGRVVTSLGMGLVGVRVSTTTLLEGFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRP 1486
               |.|..|......|   |:.|::|.:.|         :|.
Zfish   332 ---SESDQITATTEVS---GIEGIKVLSQT---------EDS----------------------- 358

  Fly  1487 QSRIVQVPW-NEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACP--- 1547
                :||.| |..:|:|...::.:...|..        .|:..:|...  |..||...|..|
Zfish   359 ----IQVDWKNPGIIVDYFKLTHASHDGQG--------GHENVVMSQE--ARTKHTIVGLNPGTE 409

  Fly  1548 -------------------------DRSAILAESQVIQESLQIPGTGLN-------LVYHSSRAA 1580
                                     |....||..:|.:.|..:...|:.       |.|  |.|.
Zfish   410 YQIGVQAIKGENEGKASFATGVTDIDAPTNLATREVTENSATVTWDGVRAEIDGYMLTY--SSAE 472

  Fly  1581 GYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFT---YAWNRLNIYRQRVYGV 1642
            |....||:...    .||..|..|:               ||:.:|   :|:......|:.:...
Zfish   473 GTSREIKVAAG----ATSYQLTSLK---------------PGVLYTVFLWAYKGSRSSRKSMTEA 518

  Fly  1643 TTAVVKVGYQYT-----DCTDIVWDIQTTKLSGHDMSISEVGGWNLDIH-------HRY-NFHEG 1694
            .|.:.......|     |...:.|:.....:.|:.:..|.:.|...::.       :|: ....|
Zfish   519 ETDIDAPTNLMTREVTEDSASVTWNKVQADIDGYMLKYSSLDGSGQEVRVGADSTSYRFTGLKPG 583

  Fly  1695 ILQ-------KGDGSNIYLRNK-------PRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVAL 1745
            :|.       ||..|:.....:       |..:||.         |..:.....|..::.|.:
Zfish   584 VLYTVYVWAIKGARSSKKSSTEAETDIDAPTNLLTQ---------EVTEDSASVTWNKVQADI-- 637

  Fly  1746 AAAPDGSLFVGDFNYIRRIMTDGSIRTVVKLNATRVSYRYHMALSPLDGTLYVSDPESHQIIRVR 1810
                ||.:       ::....|||.:. |::.|..:|||: ..|.|  |.||.        :.|
Zfish   638 ----DGYM-------LKYSSLDGSGQE-VRVGADSISYRF-TGLKP--GVLYT--------VSV- 678

  Fly  1811 DTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRM 1875
                       | ||.||........||         :.::..||                |::.
Zfish   679 -----------W-AVKGSRSSRKATTEA---------ETEIDAPK----------------NLKA 706

  Fly  1876 VDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPD 1940
            .|.....|||.        ||                       :|..|    |:.:::.....|
Zfish   707 TDVQTQTSTLT--------WK-----------------------APQAN----IEGYILTYRAED 736

  Fly  1941 GRVRVISGRPLHCATASTAYDTDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGR 2005
            |.::.:                    ..||                    :.|.||..:.|
Zfish   737 GSMQTV--------------------EKTL--------------------TARENRFALSG---- 757

  Fly  2006 IAPFAGAESKCNCLERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIP 2070
                         ||.|      :.|:.|.                  ||.:.:.|.:.|.::..
Zfish   758 -------------LEMG------KKYIVTL------------------IAYRGSKRSKIVETTFS 785

  Fly  2071 EASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTV-----TDAA 2130
            ....:.::.:   |..:|         :...|:.:|    |:|..||.:..:...|     ||..
Zfish   786 TVGLAYQFPM---DCTQI---------MRNGNMESG----VYTIYVNNNRSRTMQVYCDMKTDGG 834

  Fly  2131 GNKVFLLRDYTSQVNSIENTK------GQKCRLRMTRMKMLHEL-STPDNYNVTYEYHGPTGLLR 2188
            |..||..|: |.:|:.::..:      |:........:..:||| :||..|...::..
Zfish   835 GWIVFQRRN-TGKVDFMKKWRDYMKGFGELTEEFWLGLDKIHELTNTPTQYEARFDLG------- 891

  Fly  2189 TKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIV 2253
               ..:.|.|.. ||.|     .|.|:.:..:|:.. |.||       ||         |..:..
Zfish   892 ---SGSDRKYAV-YDNF-----KVAPSKQKFKLTIG-SYKG-------NA---------GDAMTY 930

  Fly  2254 RNGAAESRTTVDMD 2267
            ..||..|  |||.|
Zfish   931 HQGAPFS--TVDSD 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	EGF_Tenascin	1071..1098	CDD:480934
		EGF_2	1139..1162	CDD:400365
		DUF5885	<1181..1229	CDD:437064	16/47 (34%)
		EGF_2	1272..1294	CDD:400365	8/21 (38%)
		acid_disulf_rpt	1337..1363	CDD:411265	6/30 (20%)
		NHL	1750..2065	CDD:302697	51/314 (16%)
		NHL repeat	1784..1830	CDD:271323	12/45 (27%)
		NHL repeat	1854..1888	CDD:271323	7/33 (21%)
		NHL repeat	1911..1950	CDD:271323	5/38 (13%)
		NHL repeat	1972..2005	CDD:271323	4/32 (13%)
		NHL repeat	2039..2065	CDD:271323	3/25 (12%)
		RHS_repeat	2183..2217	CDD:461685	7/33 (21%)
		RhsA	<2248..2980	CDD:442442	8/20 (40%)
		Tox-GHH	3191..3268	CDD:464783
tnn	XP_005171321.1	EGF_alliinase	<133..163	CDD:398501	14/41 (34%)
		EGF_Tenascin	163..190	CDD:480934	8/26 (31%)
		EGF_Tenascin	194..221	CDD:480934	9/26 (35%)
		EGF_Tenascin	225..252	CDD:480934	15/31 (48%)
		fn3	257..333	CDD:394996	16/101 (16%)
		fn3	347..426	CDD:394996	18/124 (15%)
		FN3	405..818	CDD:442628	102/637 (16%)
		FReD	792..1003	CDD:238040	45/203 (22%)