DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-m and tenm3

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:NP_001352472.1 Gene:tenm3 / 30155 ZFINID:ZDB-GENE-990714-19 Length:2716 Species:Danio rerio


Alignment Length:2897 Identity:909/2897 - (31%)
Similarity:1429/2897 - (49%) Gaps:419/2897 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   589 DTDDIVEINTPPSQTAQRTFAA----------------VSHQPAIEHDFQIKGTDAGGLQTEKPA 637
            |::| ..:.|..|.::..|..|                :.|:.|.|:..|.:..:...|...:||
Zfish    29 DSED-CRVPTQKSYSSSETLKAFDHDSSRLLYGGHVKEMVHREADEYSRQGQNFNLRQLGICEPA 92

  Fly   638 TDDINNERDLA---------DNYEVDSKEPTSPGTPPQGKVSQQ-----------TGKASLQSLQ 682
            |     .|.||         ..|.|.:.....  |..:|.:|.:           :|:.|..|.:
Zfish    93 T-----RRGLAFCAEMGLPHRGYSVGAGSDVD--TENEGVMSPERAMRLWGRGVKSGRNSCLSSR 150

  Fly   683 SESDLMMNDASHYEDIDIVKLDGLTISHEEEIYKTADKENMAPKNQPSQHIDRSQNEVLKGHQQG 747
            |.|.|.:.|..|                    ...:|.||..|.||               ||||
Zfish   151 SNSALTLTDTEH--------------------ENKSDSENEQPSNQ---------------HQQG 180

  Fly   748 DEKQPQLEPLKPYVSERVDLPGKRIFLNLTIATDEGSDSVYTLHVEVPTGGGPHFIKEVLTHEKP 812
               |..|.|:.|        |                      |.:.|:       ...|.|...
Zfish   181 ---QSTLPPVPP--------P----------------------HKQQPS-------VTALNHNSL 205

  Fly   813 TAQADSCVPEPPPRMPDCPCSCLPPPAPI----YLDDTVDIDS-----------------APPAK 856
            :::. :..|.||..:| ......|...|:    .|...|.::|                 |.|..
Zfish   206 SSRR-NVSPAPPAALP-AELQTTPESVPLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGY 268

  Fly   857 TVTTSTI-SAPINP--------------------------------------------------F 870
            |:.|..: |.|..|                                                  .
Zfish   269 TMATGAVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWRCTALSAMAVSILLSVLLCYCIAMHLFGL 333

  Fly   871 HSEEEDDEDGVRDEEQTPSSSTATNLPSTEIDNHIAAFTEPAVGAGGVPFACPDVMPVLILEGAR 935
            :.:.::.|....:..|..|.|||||..:       |..||..|                      
Zfish   334 NWQLQETEGYAFENGQVKSDSTATNAVT-------ALSTENKV---------------------- 369

  Fly   936 TFPARSFPPDGT-TFGQITLGQKLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRRN 999
                 .|..:.| ..|::.:|::..:::.|.::|..|.:..:|..:||:.::.|||.:|||||:.
Zfish   370 -----YFQENNTIDTGEVDVGRRAVQDVPPGTFWRTQLFIDQPQSLKFNISVQRGALVGVYGRKG 429

  Fly  1000 ALPTHTQYHFKEVLSG-------------FSASTRTARAAHLSITREVTRYMEPGHWFVSLYNDD 1051
            ..||||||.|.|:|.|             ...:.|.||:.::. ..|..|:::.|.|.::.|||.
Zfish   430 LPPTHTQYDFVELLDGSRLIAKEKRGLVEVEGAARKARSVNVH-EAEFIRFLDSGTWHLAFYNDG 493

  Fly  1052 GDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGE 1116
            .:.:::::...:.:.:|: ||:.|.|||.|..|.|.|.|||.|.|||.:.||||||.:|:|:.|.
Zfish   494 KNAEQVSYNTIIIDTLTE-CPHNCHGNGDCRTGTCHCFPGFLGPDCSRAACPVLCSGNGQYSRGR 557

  Fly  1117 CICNPGWKGKECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADG 1181
            |:|..||||.||.:..::|....|||||.|:.|.|.|..||||..||||||..|:||.||.|..|
Zfish   558 CLCYSGWKGTECDVPSNQCIDIHCSGHGICIMGTCACNTGYKGDNCEEVDCLDPSCSSHGVCIHG 622

  Fly  1182 TCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGR 1246
            .|.|..||.|.:|..:   ...|...||||||:..::.||||:..|:|.|||.|:|.:|||.||.
Zfish   623 ECHCNPGWGGNNCEIL---KTMCPDQCSGHGTYQTESGTCTCDTNWTGPDCSIEVCAVDCGSHGV 684

  Fly  1247 CEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTI--------------- 1296
            |.|.:|.|:..|.|..|:.:.|..||.|||.||:|.|.|..||.|:|||:               
Zfish   685 CIGGSCRCEEGWTGSVCDLKACHPRCTEHGTCKDGKCECHQGWTGEHCTVAHPETYVQGERIGFK 749

  Fly  1297 EGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASH 1361
            ||||..|..:|:|.:...| |.|.|..||.|..|.:|:|..|.|.|||:.||||||.||:||...
Zfish   750 EGCPGLCNSNGRCTLDQNG-WHCVCQPGWRGAGCDVAMETLCADGKDNEGDGLVDCMDPDCCLQS 813

  Fly  1362 VCKTSQLCVSAPKPIDVLLRKQPPA---ITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFN 1423
            .|:|...|..:|.|||::.:.||.:   ...||::::.||....|      ....|..   |.||
Zfish   814 SCQTQPFCRGSPDPIDIISQNQPASPQQAAQSFYQQISFLTGPES------THVINGE---NPFN 869

  Fly  1424 ASRSAVIRGRVVTSLGMGLVGVRVSTTTLLE-GFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQ 1487
            .|..::|||:|:|:.|..|:||.||.....: |:|:||.||.||::.|||.::||.|.||||..|
Zfish   870 RSLVSIIRGQVLTADGTPLIGVNVSFVHYPDHGYTITRQDGMFDILANGGASLTLSFERAPFLTQ 934

  Fly  1488 SRIVQVPWNEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAI 1552
            .|.|.:|||...::|.:||. .||..:.     :|....:....|:::|:....|..:.|:...|
Zfish   935 FRTVWIPWNVFYVMDTLVMK-KEENDIP-----SCDLSGFIRPSPLIVATPLSTFFRSSPENGPI 993

  Fly  1553 LAESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIF 1617
            :.|:||:||...|||:.|||:|.|||||||...:|:.:|...||.:|..:||.:.:.|.||::.|
Zfish   994 IPETQVLQEETAIPGSDLNLMYLSSRAAGYRPVLKVTMTQATIPFNLMKVHLMVAVVGRLFQKWF 1058

  Fly  1618 EADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYTDCTD-IVWDIQTTKLSGHDMSISEVGGW 1681
            .|:|.:.:|:.|::.:.|.|||||::.|||.||::|..|.| |:|:.:|..|.|:::..|.:|||
Zfish  1059 PAEPNLSYTFIWDKTDAYNQRVYGLSEAVVSVGFEYESCLDLILWEKRTAILQGYELDASNMGGW 1123

  Fly  1682 NLDIHHRYNFHEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALA 1746
            .||.||..:...|||.||:|.|:::..:|.:|.|.||:|.:|.:.||.|:|||...:||||||||
Zfish  1124 TLDKHHVLDVQNGILYKGNGENVFVSQQPPVISTIMGNGRRRSISCPSCNGQADGNKLLAPVALA 1188

  Fly  1747 AAPDGSLFVGDFNYIRRIMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLYVSDPESHQ 1805
            ...|||||||||||||||...|::.:|::|      ::...::||::|..|:.|.|||||..|.:
Zfish  1189 CGSDGSLFVGDFNYIRRIFPSGNVTSVMELRNKDFRHSNNPAHRYYLATDPMTGQLYVSDTNSRR 1253

  Fly  1806 IIRVRDTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADG 1870
            |.|.:......:...|.|.|.|:||:|||.|||.||||..|.:|.|..|||||:..:..:||.||
Zfish  1254 IFRPKALTGTKELLQNAEVVAGTGEQCLPFDEARCGDGGKATEALLLGPKGIAVDKNGFIYFVDG 1318

  Fly  1871 TNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMIL 1935
            |.||.|||:||:|||:|::...|. :|:.|:.::.:.::.|.|||:||::||||:::::|::::|
Zfish  1319 TMIRKVDRNGIISTLLGSNDLTSA-RPLTCDNSMHIGQVRLEWPTDLAINPMDNSIYVLDNNVVL 1382

  Fly  1936 RMTPDGRVRVISGRPLHCATASTAYDT-DLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRV 1999
            ::|.:.:||:::|||:||......|.. ..|...||....:|:....|.||:||:|.::|||:|.
Zfish  1383 QITENRQVRIVAGRPMHCQVPGIEYTMGKRAIQTTLEGATAISLSYSGVLYIAETDEKKINRIRQ 1447

  Fly  2000 IGTDGRIAPFAGAESKCNCL-ERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIR 2063
            :.|||.|:..|||.|.|:|. :..|||::.....|..|:.|..::|.|:||..:::||..|.|||
Zfish  1448 VSTDGEISHLAGAPSDCDCKNDANCDCYQTGDGYAKDARLNAPSSLVVSPDGTLYVADLGNIRIR 1512

  Fly  2064 SVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTD 2128
            ::..:.|....|..:|:.:|..||:|:|:..|.|..|.:::||:..|.|:|   ::...::.|||
Zfish  1513 AIRHNRPPQGSSGLFEVASPASQELYVFDSNGTHQYTMSLVTGDYKYNFSY---SNEDDVTAVTD 1574

  Fly  2129 AAGNKVFLLRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDS 2193
            ::||.:.:.||.......|.....|...|.:.....|..|:......|.:.|||.:|||.||...
Zfish  1575 SSGNTLRVRRDPNRMPVRIVAPDNQVIWLTIGTNGGLKTLTAQGQELVLFTYHGNSGLLATKSIQ 1639

  Fly  2194 TGRSYVYNYDEFGRLTSAVTPTG----------RVIELSFDLSVKGAQVKVSENAQKEMSL--LI 2246
            .|.:..|:||..||||:...|||          |.:.:..:.|.:...|.::.|.....|.  |:
Zfish  1640 IGWTTFYDYDSEGRLTNVTFPTGVITSLIGEMDRALTVDIETSGRDDDVSITTNLSSIDSFYTLV 1704

  Fly  2247 QGATVIVRNGAAESRTTVDMDGSTTSITPWGHNLQMEVAPYTILAEQSPLLGESYPVPAKQRTEI 2311
            |..   :||.     ..|..|.|...|...|.:...:..|: |||      |.|.|..|::...:
Zfish  1705 QDQ---LRNS-----YQVGYDNSMRVIYANGMDSHFQTEPH-ILA------GASNPTVARRNMTL 1754

  Fly  2312 AGDLA-NRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVD 2375
            .|:.. |..|||:  |::|  ..||        |...||||||||.|:|:::|||..::..:..|
Zfish  1755 PGENGQNLVEWRF--RKEQ--NRGK--------VVVFGRKLRVNGRNLLSVDYDRSLRTEKIYDD 1807

  Fly  2376 DKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYG 2440
            .::.||.:.||.:..|..:.| |.....|:|.|...|::.|.:.|...|...:|..||:....:.
Zfish  1808 HRKFLLKIVYDASGHPTLWVP-SSKLMSVNLTYSSTGQVTSLQRGPTTERVEYDSQGRIVSRTFA 1871

  Fly  2441 DGSTMVYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGFFKYQYY 2505
            |.....|.:.|.  |:.|.:.:.|:  |:..||....|.::|.|....|......|:|:::..|.
Zfish  1872 DAKIWSYTYLDK--SMVLLLHSQRQ--YIFDYDLQDRLSAITMPSVARHTMQTIRSVGYYRNIYN 1932

  Fly  2506 SPINRHPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKSVE 2570
            .|.:.....:.|:::||:|...|.....:|.:.:....:|..||...:...:||.:|..::|:|.
Zfish  1933 PPESNASVTVDYSEDGQLLRVAHLGTGRRVLYKYRRQNKLSEILYDSTRVSFTYDETAGVLKTVN 1997

  Fly  2571 VQEPGFELRREFKYHAGILKDEKLRFGSKNSLASARYKYAYDGNARLSGIEMAIDDKELPTTRYK 2635
            :|..||.....:: ..|.|.|.::...|::.:.:||:.|.||.:.|::.::..|::..||...|:
Zfish  1998 LQSEGFICSIRYR-QIGPLVDRQIFRFSEDGMVNARFDYTYDNSFRVTSMQGVINETPLPIDLYQ 2061

  Fly  2636 YSQNLGQLE-------VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKNIDVF 2693
            :....|::|       :..|:    |....|.:....|.|      |.|||:|.:...:....::
Zfish  2062 FDDISGKVEQFGKFGVIYYDI----NQIISTAVMTYTKHF------DVHGRIKEIQYEIFRSLMY 2116

  Fly  2694 RLELDYDLRNRIKSQKTTFG--RSTAFDKINYNADGHVVEVLGTNN--WKYLFDENGNTVGVVDQ 2754
            .:.:.||...|:..::...|  .:|......|:.||.:..|.....  |:|.:|.||| :.:::.
Zfish  2117 WITIQYDNMGRVTKREIKIGPFANTTKYGYEYDVDGQLQTVYLNEKMMWRYNYDLNGN-LHLLNP 2180

  Fly  2755 GEKFN---LGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQL--IHSFERERFQSW- 2813
            |....   |.||:.||:.::|||:: ..|..||:.:||.:.:.||::|.|  :||    :...| 
Zfish  2181 GNSARLTPLRYDLRDRITRLGDVQY-RMDEDGFLRQRGAEIFEYNSKGLLVRVHS----KASGWT 2240

  Fly  2814 --YYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALE-HED 2875
              |.||...|.:|..::.|...|::||:...|..:|||:....|....|:||.:..|.|:| ...
Zfish  2241 IQYRYDGLGRRLASRNSLGQHLQFFYADLNYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSG 2305

  Fly  2876 QRYYVATDQNGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQ 2940
            :.:|:|.|..|:|||.|..||.::|:::.|.:|.|..|:.|:|.:.|.|||||.||.|:|::..:
Zfish  2306 EEFYIACDNTGTPLAVFSSNGLLLKQVQYTAYGEIYFDSNPDFQLVIGFHGGLYDPLTRLLHFGE 2370

  Fly  2941 RQYDPHVGQWMTPLWETLATEMSHPTDVFIYRYHNNDPINP-NKPQNYMIDLDSWLQLFGYDLNN 3004
            |.||...|:|.||...|.......|....:|.:.||:||:. ::.:.|:.|::.||..||:.|:|
Zfish  2371 RDYDIQAGRWTTPDISTWTRVGKDPAPFNLYMFRNNNPISKIHEVKEYVTDVNIWLVTFGFHLHN 2435

  Fly  3005 -MQSSRYTKLAQYTPQASIKSNTLAPDFGVISGLECIVEKTSEKFSDFDFVPKPLLKMEPKMRNL 3068
             :......|.....|...::.:.|..|...|||::..|.:.::.|..|:.:|:..|......|. 
Zfish  2436 VIPGFPIPKFDLTQPSLEMRKSQLWDDLPSISGVQQEVMRQAKAFLSFERMPEIQLSRRRSSRE- 2499

  Fly  3069 LPRVSYR--RGVFGEGVLLSRIGGRALVSVVDGSNSVVQDV--VSSVFNNSYFL-DLHFSIHDQD 3128
            .|.:.:.  :.:.|:||:|: |..:..|: .:..|...:|.  |::|.||:::| ||||::..:|
Zfish  2500 KPWLWFATVKSLIGKGVMLA-ITSKGQVA-TNALNIANEDCIKVATVLNNAFYLEDLHFTVEGRD 2562

  Fly  3129 VFYFVKDNV-------LKLRDDNEELRRLGGMFNIS---------THEISD----HGGSAAKELR 3173
            ..||:|.::       |:|....:.|.. |....:|         |...:|    :|.     |.
Zfish  2563 THYFIKTSLPESDLGALRLTSGRKSLEN-GVNVTVSQSTTVVNGRTRRFADVELQYGA-----LA 2621

  Fly  3174 LHGPDAVVIIKYGVDPEQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEKEELVQHG 3238
            ||       ::||:..::|:.|:|:.|.:||:..||..|:|.|..|.:|...|||.||.:|:..|
Zfish  2622 LH-------VRYGMTLDEEKARVLEQARQRALSSAWAREQQRVRDGEEGVRLWTEGEKRQLLSSG 2679

  Fly  3239 DVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            .|.|::|..:.|:.:||:|||...||.|.|.::..:|
Zfish  2680 KVLGYDGYYVLSVEQYPELADSANNVQFLRQSEIGKR 2716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 67/128 (52%)
CRD2 1106..1151 CDD:276900 21/44 (48%)
EGF_2 1139..1162 CDD:285248 13/22 (59%)
Keratin_B2 1162..1330 CDD:279797 80/182 (44%)
EGF_2 1167..1194 CDD:285248 13/26 (50%)
DUF3844 1171..>1235 CDD:289707 28/63 (44%)
EGF_2 <1272..1294 CDD:285248 12/21 (57%)
NHL 1750..2065 CDD:302697 135/322 (42%)
NHL repeat 1784..1830 CDD:271320 17/45 (38%)
NHL repeat 1854..1888 CDD:271320 20/33 (61%)
NHL repeat 1911..1950 CDD:271320 16/38 (42%)
NHL repeat 1972..2005 CDD:271320 13/32 (41%)
NHL repeat 2039..2065 CDD:271320 11/25 (44%)
RHS_repeat 2183..2218 CDD:283287 16/44 (36%)
RhsA 2347..3020 CDD:225750 198/694 (29%)
YD_repeat_2x 2795..2836 CDD:273728 14/45 (31%)
Rhs_assc_core 2905..2980 CDD:274730 29/74 (39%)
Tox-GHH 3193..3268 CDD:292269 31/74 (42%)
tenm3NP_001352472.1 Ten_N 11..305 CDD:310827 65/360 (18%)
EGF_2 512..538 CDD:285248 14/25 (56%)
Keratin_B2 581..712 CDD:330888 65/133 (49%)
EGF_2 <710..732 CDD:285248 12/21 (57%)
EGF_CA 753..782 CDD:238011 11/29 (38%)
NHL 1155..1514 CDD:302697 155/359 (43%)
NHL repeat 1184..1223 CDD:271320 23/38 (61%)
NHL repeat 1235..1278 CDD:271320 15/42 (36%)
NHL repeat 1302..1336 CDD:271320 20/33 (61%)
NHL repeat 1358..1397 CDD:271320 16/38 (42%)
NHL repeat 1420..1453 CDD:271320 13/32 (41%)
RhsA 1480..>2038 CDD:225750 165/593 (28%)
NHL 1483..>1610 CDD:302697 38/129 (29%)
NHL repeat 1488..1514 CDD:271320 11/25 (44%)
NHL repeat 1490..1525 CDD:271320 11/34 (32%)
NHL repeat 1564..1607 CDD:271320 10/42 (24%)
YD_repeat_2x 1839..1879 CDD:273728 9/39 (23%)
RHS_repeat 2223..2260 CDD:310291 12/40 (30%)
RhsA 2334..2412 CDD:332076 30/77 (39%)
Tox-GHH 2634..2709 CDD:317945 31/74 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581623
Domainoid 1 1.000 1065 1.000 Domainoid score I23
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1467 1.000 Inparanoid score I109
OMA 1 1.010 - - QHG52630
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm24228
orthoMCL 1 0.900 - - OOG6_100953
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1312.910

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