DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-m and tncb

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	NP_001299845.1	Gene:	tncb / 30037	ZFINID:	ZDB-GENE-980526-104	Length:	1811	Species:	Danio rerio

Alignment Length:	1773	Identity:	390/1773 - (21%)
Similarity:	593/1773 - (33%)	Gaps:	595/1773 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 CPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDEC 1135
            |||.|...|:|..|.|.|:.||.|:||.|..||..|:.||...||:||||.|:.|::||..  .|
Zfish   287 CPNDCFDRGRCENGTCYCDEGFTGEDCGELTCPQNCNHHGRCVNGQCICNIGYSGEDCSKL--TC 349

  Fly  1136 EVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQD 1200
             :.|||..|||.:|||.|..|::|:.|..:.|| .||:|.|.|.:|.|||..|::|.||:
Zfish   350 -LNDCSERGHCFNGKCICDPGFEGEDCSLLSCP-DNCNGRGHCVNGECICGPGYEGDDCS----- 407

  Fly  1201 ALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNT 1265
            .|.||.:|...|.  .....|.|:|.::|:|||.:.|..||...|.|....|.|...:.||:|..
Zfish   408 ELSCLNNCHDRGR--CVNGKCICKAGFAGEDCSIKTCPHDCHGRGECVDGKCVCHDGFAGEHCGI 470

  Fly  1266 RLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDC 1330
            :.|...|:.||||.:|.|:|..|:.|:.|:|:.|||.|.|.||| :.|    :|.|::|:.|.||
Zfish   471 KTCPHHCHGHGQCVDGKCICHKGFAGEDCSIKTCPNHCHGQGQC-IDG----KCICHDGFAGEDC 530

  Fly  1331 GIALELN-------CGDSKDNDKDGLV-----------DCED-PEC----CASHVCKTSQLCVSA 1372
            .|....|       |.|.|....||..           ||.| .||    |..|...|...|...
Zfish   531 SIKTCPNHCHGRGRCVDGKCICHDGFAGEDCNIKTCPNDCHDHGECVDGKCICHAGFTGHDCSEL 595

  Fly  1373 PKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTS 1437
            ..|.|.                                             .:|...:.|:.|.:
Zfish   596 TCPNDC---------------------------------------------HNRGRCVNGQCVCN 615

  Fly  1438 LGMGLVGVRVSTTT-----------------LLEGFT------LT-----RDDGWFDLMVNGGGA 1474
            :  |..|....|.|                 ..||:|      ||     .|.|   ..:||...
Zfish   616 I--GFTGEDCGTKTCPNNCLDRGFCEDGKCVCFEGYTGEDCSVLTCPADCNDQG---QCLNGMCI 675

  Fly  1475 VTLQFGR------APFR--------PQSRIVQVPW-NEVVIIDLVV-------------MSMSEE 1511
            ..|.|..      :|.|        |::  |.|.| ||:::.:.::             |.:|.|
Zfish   676 CDLGFTGDDCSEISPPRDLTVTEVDPET--VDVAWVNEMLVTEYLITYVPTAPGGLEMEMRVSGE 738

  Fly  1512 KGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHS 1576
            |                  |...:...:.|.:       .:::...|:...:.:|        .|
Zfish   739 K------------------KTATIRELEPGIE-------YLISVFAVLNSKMSVP--------VS 770

  Fly  1577 SRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNIYRQRVYG 1641
            :|.|.:|        |:.              ||:.|:.:.|....::    |:.|||
Zfish   771 ARIATHL--------PEP--------------EGLKFKSVKETSVEVE----WDPLNI------- 802

  Fly  1642 VTTAVVKVGYQYTDCTDIVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGIL---------- 1696
                                               ...||||...:.......||
Zfish   803 -----------------------------------PFDGWNLIFRNTKEEDGEILNSLAPPETTF 832

  Fly  1697 -QKGDGSNIYLRNKPRII------------LTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAA 1748
             |.|.|.......|..::            :.||.|...: ::..|..........|.|||..
Zfish   833 EQSGLGPGQEYEVKLEVVKNNTRGPPASKNVVTMIDAPSQ-VDVRDVTDTTALVTWLQPVAQV-- 894

  Fly  1749 PDG-SLFVGDFNYIRRIMTDGSIRTVVKLNATRVSYRYHMA-LSPLDGTLYVSDPESHQIIRVRD 1811
             || |:..|.       .||.|.|..::|::  :..:||:| |||        |.|....:..|.
Zfish   895 -DGISVSYGP-------NTDSSDRNTIELSS--IETQYHLAELSP--------DTEYEVSLMARR 941

  Fly  1812 ------------TNDYSQPE-----------------------LNWEAVVGSGERCLPGDEAHCG 1841
                        |.|...|:                       ||:....|.    |.|.|
Zfish   942 GEMSSFPIYETFTTDLDSPKHLKAIEQTDESITLEWRNSRANVLNYRVKYGP----LSGGE---- 998

  Fly  1842 DGALAKDAKLAYPKGIAISSD-NILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLK 1905
                  ..:|.:|.|:..::. .|.....||...|    |:.|.       |...:.:|......
Zfish   999 ------HGELVFPSGLQDTTQAKITGLRPGTEYGM----GVTSI-------KEERESLPATTNAV 1046

  Fly  1906 LEEMHLRWPTELAVS-PMDNTLHI--------IDDHMILRMTPDG-----------RVRVISG-R 1949
            .:   |..|.:|.|| ..:.||.:        ||.:.::.:..||           ...:::| .
Zfish  1047 TD---LDPPKDLQVSETTETTLALVWRRPVAKIDTYSLVFIPADGDKTELKIPGAANTYILTGLN 1108

  Fly  1950 P--LHCATASTAYDTDLATHATLVMPQSIAFGPLGELYVAE------SDSQRINRVRVIG----- 2001
            |  ||..|.:......::..|||..........:|.:.:::      |.|..::|..|.|
Zfish  1109 PGMLHTITLTAERGRKMSAPATLSASTDEEKPQVGNITISDVSWDSFSMSWDLDRGEVEGFLIEV 1173

  Fly  2002 ------TDGRIAPFAGAESKCNCLERGCDCFEAEHYLAT------SAKFNTIAALAVT---PD-S 2050
                  :||:....:|.|......:.....|    |..|      ....:.:.|.|:|   |: .
Zfish  1174 SDPDGLSDGQNHTLSGQEFSLAVTDLSPSTF----YRVTLYGLYKGELLDPVFAEAITEAEPEVE 1234

  Fly  2051 HVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHV----------------- 2098
            |:.::|...:..: |..:.|||                 :|:.|...|
Zfish  1235 HITVSDITPHSFK-VTWTAPEA-----------------VFDSFALKVLDSSGLGRPHQISVSGD 1281

  Fly  2099 STRNILTG---ETTY---------------VFTY---NVNTSNG-KLSTVTDAA----------- 2130
            .....:||   :|.|               :||.   .:.|..| :.|.|||.:
Zfish  1282 KRTEAVTGLNEDTDYEIELFGIILGRKFQPIFTVARTGLGTPKGIRFSDVTDTSATVHWTMPHTR 1346

  Fly  2131 -------------GNKVFLLRDYTSQVNSIEN-TKGQKCRLRMTRMKMLHELSTPDNYNVTYEYH 2181
                         |:.:.|..|.......:.| |.|...::.:..:|.|.| |.|.:..||....
Zfish  1347 VDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVKGLEE-SEPGSERVTTALD 1410

  Fly  2182 GPTGLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSEN-AQKEMSLL 2245
            .|.||....:..|....::.       .|..|..|.||..|.| ||.....:||.| .:.|||.|
Zfish  1411 KPRGLTAVNISDTEALLLWQ-------PSIATVDGYVITYSAD-SVAPVMERVSGNTVEFEMSSL 1467

  Fly  2246 IQGATVIV---------RNGAAESRTTVDMDG----------STTSITPW--------GHNLQME 2283
            .......|         ::.|..:..|.|:|.          :.|::..|        |:.|..|
Zfish  1468 TPATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPPRADISGYILSFE 1532

  Fly  2284 ----VAPYTILAEQSPLLGESYPVPAKQRT----EIAGDLANRFEWRYFVRRQQPLQAGKQSKGP 2340
                |....:|:..:.....|....:.:.|    .|||...:|.....|      |..|...|.|
Zfish  1533 SADGVVKEVVLSPTATFYSMSQLTASTEYTVKLQAIAGPKRSRVISTVF------LTIGVLYKHP 1591

  Fly  2341 PRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQEL---LNVTYDRTSRPISFRPQSGDYA 2402
                .:..:.| :|||....|      .::.:..|:.|.|   .::|.|.....:..|.|||
Zfish  1592 ----KDCSQAL-LNGDTTSGL------YTIYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSG--- 1642

  Fly  2403 DVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLPLKVTTPRRSD 2467
              .:|:.|     :||    .....|   |.||: ::..|.:.::.... ||...|:|....:.:
Zfish  1643 --KVEFFR-----NWK----NYTAGF---GDLND-EFWLGLSNLHKITS-FGQYELRVDLRDKGE 1691

  Fly  2468 -YLLQYDDAGALQSLTTPRG----HIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEGQILAKI 2527
             ...|||..    |::.||.    |:..:| .|:.....|.:     ..||....||..  :|..
Zfish  1692 SAYAQYDKF----SISEPRARYKVHVGGYS-GTAGDSMTYHH-----GRPFSTYDNDND--IAVT 1744

  Fly  2528 HPHQSGKVAFVHDTAGRL 2545
            :...|.|.||.:....|:
Zfish  1745 NCALSYKGAFWYKNCHRV 1762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	59/126 (47%)
		CRD2	1106..1151	CDD:276900	21/44 (48%)
		EGF_2	1139..1162	CDD:285248	12/22 (55%)
		Keratin_B2	1162..1330	CDD:279797	64/167 (38%)
		EGF_2	1167..1194	CDD:285248	13/26 (50%)
		DUF3844	1171..>1235	CDD:289707	25/63 (40%)
		EGF_2	<1272..1294	CDD:285248	10/21 (48%)
		NHL	1750..2065	CDD:302697	76/402 (19%)
		NHL repeat	1784..1830	CDD:271320	15/81 (19%)
		NHL repeat	1854..1888	CDD:271320	8/34 (24%)
		NHL repeat	1911..1950	CDD:271320	12/59 (20%)
		NHL repeat	1972..2005	CDD:271320	7/49 (14%)
		NHL repeat	2039..2065	CDD:271320	6/29 (21%)
		RHS_repeat	2183..2218	CDD:283287	7/34 (21%)
		RhsA	2347..3020	CDD:225750	47/207 (23%)
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
tncb	NP_001299845.1	DnaJ	<471..>544	CDD:333066	30/77 (39%)
		fn3	689..760	CDD:306538	14/97 (14%)
		fn3	778..858	CDD:306538	19/139 (14%)
		fn3	868..948	CDD:306538	24/100 (24%)
		FN3	958..1047	CDD:238020	18/113 (16%)
		fn3	1050..1128	CDD:306538	15/77 (19%)
		fn3	1140..1215	CDD:306538	13/78 (17%)
		fn3	1231..1303	CDD:306538	14/89 (16%)
		fn3	1323..1400	CDD:306538	15/77 (19%)
		fn3	1410..1482	CDD:306538	21/79 (27%)
		fn3	1498..1570	CDD:306538	11/71 (15%)
		FReD	1589..1798	CDD:238040	49/216 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900