DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-m and Tnr

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	NP_037177.2	Gene:	Tnr / 25567	RGDID:	3886	Length:	1358	Species:	Rattus norvegicus

Alignment Length:	1544	Identity:	297/1544 - (19%)
Similarity:	499/1544 - (32%)	Gaps:	516/1544 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 ESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDECE---------------VADCSGHGHCVS 1148
            :..||  |:...:... |.:.......:|.|:..|:|.               |..|||||:...
  Rat   122 KKACP--CASSAQVLQ-ELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSF 183

  Fly  1149 GKCQCM--RGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGH 1211
            ..|.|:  .|:.||.|.|..|| ..||..|.|.||.||
  Rat   184 ESCGCICNEGWFGKNCSEPYCP-LGCSSRGVCVDGQCI--------------------------- 220

  Fly  1212 GTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHG 1276
                       |::::||||||:..|..||...|.|....|.|:..:.||.|....|...|:..|
  Rat   221 -----------CDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKG 274

  Fly  1277 QCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDS 1341
            ||.||||||..|:.|:.|:...|.|:|:|.|.|:   ||.  |.|.||:.||||....     ..
  Rat   275 QCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQ---EGL--CICEEGYQGPDCSAVT-----PP 329

  Fly  1342 KDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPI-DVLLRKQPPAITASFFERMKFLIDESSLQ 1405
            :|....|:.|            ::.:|....|..: :.::..||.|:..  .:..:.:..:.|..
  Rat   330 EDLRVAGISD------------RSIELEWDGPMAVTEYVISYQPTALGG--LQLQQRVPGDWSGV 380

  Fly  1406 NYAKLE---TFNESIFWNYFNASRSAVIRGRVVTSLG--MGLVGVRVSTTTL---LEGFTLTRDD 1462
            ...:||   |:|.|::....|. .|..|..:|.|.|.  .||....::.||:   .|.|:.: .|
  Rat   381 TITELEPGLTYNISVYAVISNI-LSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFS-FD 443

  Fly  1463 GW---FDLMVNGGGAV------TLQFGRAPFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGLAVTT 1518
            ||   |....|.||.:      ...|.:...:|         .|..|::  |:::.|:.....|:
  Rat   444 GWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKP---------GEEYIVN--VVALKEQARSPPTS 497

  Fly  1519 THTCFAHD-------YDLMKPVVLASW------------KHGFQGACPDRSAILAESQVIQESLQ 1564
            .......|       .|:...|....|            |:|..|....::....:..:.|.|:|
  Rat   498 ASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQ 562

  Fly  1565 I--PGTGLNLVYHSSRAAGYLSTIKLQLTPDV-IPTSLHLIHLRITIEGILFERIFEADPGIKFT 1626
            .  ||:...:...:.|..........|.|.:: .|.:|
  Rat   563 ALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNL--------------------------- 600

  Fly  1627 YAWNRLNIYRQRVYGVTTAVVKVGYQYTDCTDIVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNF 1691
                                 :||.:.....|:.||....:...:.:..|.:.|        ..:
  Rat   601 ---------------------RVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAG--------EQY 636

  Fly  1692 HEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVG 1756
            ||.::.||.|..........:..|..|.|....:.        :||.:.|.:......|..
  Rat   637 HEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMN--------SKQSIPATMNARTELDSP---- 689

  Fly  1757 DFNYIRRIMTDGSIRTVVKLNATRVS---YRYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQP 1818
                 |.:|...|..|.:.|..|:.|   ..|.:..:|..|.       |.::...||...|:..
  Rat   690 -----RDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGI-------SSEVTVPRDRTSYTLT 742

  Fly  1819 ELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVS 1883
            :|.            ||.|..                 |:|:::.      |   |....:..|.
  Rat   743 DLE------------PGAEYI-----------------ISITAER------G---RQQSLESTVD 769

  Fly  1884 TLIG----NHMHKSHWKPIPCEGTLKLEEMHLRW-----PTE---LAVSPMDNTLHIIDDHMILR 1936
            ...|    :|:|.||         :....:::.|     |.:   |..||.|..    ::.|.:.
  Rat   770 AFTGFRPISHLHFSH---------VTSSSVNITWSDPSPPADRLILNYSPRDEE----EEMMEVL 821

  Fly  1937 MTPDGRVRVISG-RPLHCATASTAYDTDL-ATHATLV---MPQSIAFG--PLGELYVAESDSQRI 1994
            :....|..|:.| :|      :|.|..:| |.|.|:.   :..||..|  |...:.::......:
  Rat   822 LDATKRHAVLMGLQP------ATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSL 880

  Fly  1995 NRVRVIGTDGRIAPFAGAESKCNCLERGCDCFEAEH------YLATSAKFNTIAALAVT---PDS 2050
                .:.....:|||              |.:...:      .|.:|...||:....:|   |.:
  Rat   881 ----TVSWSPPVAPF--------------DYYRVSYRPTQVGRLDSSVVPNTVTEFTITRLYPAT 927

  Fly  2051 HVHIA------DQANYRIRSVMSSIPEA---------SPSREYEIYAPDMQEI--YIFNRFGQHV 2098
            ...|:      .:.:.||.:::.:..::         :|:.....:...|.|:  |:.      |
  Rat   928 EYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVI------V 986

  Fly  2099 STRNILTGETTYV-----------------FTYNVNTSNGKLSTVTDAAGNKVFLLRDYTSQVNS 2146
            .|...:.|||..|                 :|..:..::|.|.:.|.|......|  |..:.:.:
  Rat   987 LTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLL--DPPANLTA 1049

  Fly  2147 IENTKGQKCRLRMTRMKMLHELSTP----DNYNVTYEYHGPTGLLRTKLDSTGRSYVYNYDEFGR 2207
            .|          :||...|.....|    :||.:||:          ..|.:.:..:.:.::..
  Rat  1050 SE----------VTRQSALISWQPPRAAIENYVLTYK----------STDGSRKELIVDAEDTW- 1093

  Fly  2208 LTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTVD------- 2265
                             :.::|    :|||.  :.::|:|.|....|:....:..|..
  Rat  1094 -----------------IRLEG----LSENT--DYTVLLQAAQEATRSSLTSTIFTTGGRVFSHP 1135

  Fly  2266 -------MDGSTTSITPWGHNLQMEVAPYTILAEQSPLLGESYPVPAKQRTEIAGDLANRFE--- 2320
                   |:|.|.|            ..|||.                    :.|:|:::.:
  Rat  1136 QDCAQHLMNGDTLS------------GVYTIF--------------------LNGELSHKLQVYC 1168

  Fly  2321 --------WRYFVRRQQPLQAGKQSKGPPR------------------PVTEVGR-KLRV---NG 2355
                    |..|.|||.......:.....|                  .:|..|| :|||   :|
  Rat  1169 DMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRDG 1233

  Fly  2356 DNVLTLEYDRETQSVVVMVDDKQELLNVT---YDRTS---------RPISFRPQSGDYADVDLEY 2408
            ...:...||:      ..|:|.:.|..:.   |:.|:         ||.|...:..|.|..:...
  Rat  1234 QEAVFAYYDK------FAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292

  Fly  2409 DRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLP 2457
            ...|   :| |  .:..:..:.||:..|.::..|... |.:|....|:|
  Rat  1293 SYKG---AW-W--YKNCHRTNLNGKYGESRHSQGINW-YHWKGHEFSIP 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	31/115 (27%)
		CRD2	1106..1151	CDD:276900	12/59 (20%)
		EGF_2	1139..1162	CDD:285248	10/24 (42%)
		Keratin_B2	1162..1330	CDD:279797	57/167 (34%)
		EGF_2	1167..1194	CDD:285248	10/26 (38%)
		DUF3844	1171..>1235	CDD:289707	15/63 (24%)
		EGF_2	<1272..1294	CDD:285248	12/21 (57%)
		NHL	1750..2065	CDD:302697	63/351 (18%)
		NHL repeat	1784..1830	CDD:271320	8/45 (18%)
		NHL repeat	1854..1888	CDD:271320	6/37 (16%)
		NHL repeat	1911..1950	CDD:271320	10/47 (21%)
		NHL repeat	1972..2005	CDD:271320	4/34 (12%)
		NHL repeat	2039..2065	CDD:271320	7/34 (21%)
		RHS_repeat	2183..2218	CDD:283287	1/34 (3%)
		RhsA	2347..3020	CDD:225750	29/127 (23%)
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
Tnr	NP_037177.2	exchanger_TraA	<190..>328	CDD:411343	62/186 (33%)
		EGF_Tenascin	203..231	CDD:376143	15/66 (23%)
		fn3	328..398	CDD:394996	14/83 (17%)
		fn3	416..496	CDD:394996	19/91 (21%)
		fn3	507..586	CDD:394996	12/78 (15%)
		FN3	595..679	CDD:238020	19/147 (13%)
		fn3	687..766	CDD:394996	23/132 (17%)
		fn3	776..855	CDD:394996	21/97 (22%)
		fn3	865..944	CDD:394996	12/96 (13%)
		fn3	954..1026	CDD:394996	11/77 (14%)
		FN3	1042..1127	CDD:238020	19/128 (15%)
		FReD	1134..1342	CDD:238040	45/246 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810