DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ten-m and Tenm3

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:XP_036009877.1 Gene:Tenm3 / 23965 MGIID:1345183 Length:2765 Species:Mus musculus


Alignment Length:2758 Identity:873/2758 - (31%)
Similarity:1380/2758 - (50%) Gaps:396/2758 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   724 APKNQPSQHIDRSQNEVLKGHQQGDEKQPQLEPLKPYVSERVDLPGKRIFLNLTIATDEGSDSVY 788
            ||.:.|..|.:.::.:....:..|   ||.|:||.|                             
Mouse   198 APGSAPHGHGEGARRQEQPSNNPG---QPTLQPLPP----------------------------- 230

  Fly   789 TLHVEVPTGGGPHFI---KEVLTHEKPTAQADSCVPEPPPRMPDCPCSCLPPPAPIYLDDT---- 846
             .|.:.|....|...   :..||:.:..:      |.||..:   |......|..:.|.|:    
Mouse   231 -SHKQHPAQHHPSITSLNRNSLTNRRNQS------PAPPAAL---PAELQTTPESVQLQDSWVLG 285

  Fly   847 --VDIDS------------------------------APPAKTVTTSTISAPINPF--------- 870
              |.::|                              :||.:.:..:|:|.....|         
Mouse   286 SNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSW 350

  Fly   871 ----------------------------------HSEEEDDEDGVRDEEQTPSSSTATNLPSTEI 901
                                              .:|.:..|:|..:.:..|:::  .:|||.: 
Mouse   351 RCTALCAVGVSVLLAILLSYFIAMHLFGLNWHLQQTENDTFENGKVNSDTVPTNT--VSLPSGD- 412

  Fly   902 DNHIAAFTEPAVGAGGVPFACPDVMPVLILEGARTFPARSFPPDGTTF--GQITLGQKLTKEIQP 964
            :..:..||.                                  :..|.  |::.:|::..:|:.|
Mouse   413 NGKLGGFTH----------------------------------ENNTIDSGELDIGRRAIQEVPP 443

  Fly   965 YSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRRNALPTHTQYHFKEVLSG----------FSAS 1019
            ..:|..|.:..:|.::||:.::.:.|.||||||:...|:||||.|.|:|.|          ...|
Mouse   444 GIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRNLVES 508

  Fly  1020 TRTARAAHLSITREV--TRYMEPGHWFVSLYNDDGDVQELTFYAAVAEDMTQNCPNGCSGNGQCL 1082
            .|..|.|......|.  .:|::.|.|.::.|||..:.::::|...|.|.:.: ||..|.|||:|:
Mouse   509 ERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNPEQVSFNTIVIESVVE-CPRNCHGNGECV 572

  Fly  1083 LGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDECEVADCSGHGHCV 1147
            .|.|.|.|||.|.|||.:.||||||.:|:|:.|.|:|..||||.||.:...:|....|.|.|.|:
Mouse   573 SGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICI 637

  Fly  1148 SGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHG 1212
            .|.|.|..||||:.|||.||..|.||.||.|..|.|.|..||.|.:|..:   ...|...|||||
Mouse   638 MGSCACNSGYKGENCEEADCLDPGCSNHGVCIHGECHCNPGWGGSNCEIL---KTMCADQCSGHG 699

  Fly  1213 TFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQ 1277
            |:..::.:|||:..|:|.|||.|:|.:|||.||.|.|.:|.|:..|.|..||.|.|..||.|||.
Mouse   700 TYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGSCRCEEGWTGPACNQRACHPRCAEHGT 764

  Fly  1278 CKNGTCLCVTGWNGKHCTI----------------EGCPNSCAGHGQCRVSGEGQWECRCYEGWD 1326
            ||:|.|.|..||||:||||                ||||..|..:|:|.:...| |.|.|..||.
Mouse   765 CKDGKCECSQGWNGEHCTIAHYLDKIVKADKIGYKEGCPGLCNSNGRCTLDQNG-WHCVCQPGWR 828

  Fly  1327 GPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPIDVLLRK-QPPAITA- 1389
            |..|.:|:|..|.|||||:.|||:||.||:||....|:....|...|.|.|::.:. |.|:..| 
Mouse   829 GAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQTPSQQAA 893

  Fly  1390 -SFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTSLGMGLVGVRVSTTTLL 1453
             ||::|:.|||...|.........||:|:         ::||||:|:|:.|..|:||.||.....
Mouse   894 KSFYDRISFLIGSDSTHVLPGESPFNKSL---------ASVIRGQVLTADGTPLIGVNVSFLHYS 949

  Fly  1454 E-GFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGLAVT 1517
            | |:|:||.||.|||:.|||.::||.|.|:||..|...|.:|||...::|.:||. .||..:.  
Mouse   950 EYGYTITRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMK-KEENDIP-- 1011

  Fly  1518 TTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHSSRAAGY 1582
               :|....:....|::::|....|..:.|:.|.|:.|:||:.|...||||.|.|.|.|||||||
Mouse  1012 ---SCDLSGFVRPSPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGY 1073

  Fly  1583 LSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNIYRQRVYGVTTAVV 1647
            .|.:|:.:|..|||.:|..:||.:.:.|.||::.|.|.|.:.:|:.|::.:.|.|:|||::.|||
Mouse  1074 KSVLKITMTQAVIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVV 1138

  Fly  1648 KVGYQYTDCTDI-VWDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGILQKGDGSNIYLRNKPR 1711
            .|||:|..|.|: :|:.:|..|.|:::..|.:|||.||.||..:...|||.||:|.|.::..:|.
Mouse  1139 SVGYEYESCLDLTLWEKRTAVLQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPP 1203

  Fly  1712 IILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKL 1776
            ::.:.||:|.:|.:.||.|:|||...:||||||||...||||:||||||:|||...|::.:|::|
Mouse  1204 VVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLEL 1268

  Fly  1777 ------NATRVSYRYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQPELNWEAVVGSGERCLPG 1835
                  :::..::||::|..|:.|.|||||..:.:|.|.:..........|.|.|.|:||:|||.
Mouse  1269 RNKDFRHSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPF 1333

  Fly  1836 DEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPC 1900
            |||.||||..|.:|.|..|||:||..:.::||.|||.||.||::||:|||:|::...|. :|:.|
Mouse  1334 DEARCGDGGKAVEATLMSPKGMAIDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSA-RPLTC 1397

  Fly  1901 EGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPDGRVRVISGRPLHCATASTAYDTDL- 1964
            :.::.:.::.|.|||:||::||||:::::|::::|::|.:.:||:.:|||:||......|.... 
Mouse  1398 DTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKH 1462

  Fly  1965 ATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESKCNCL-ERGCDCFEA 2028
            |...||....:||....|.||:.|:|.::|||:|.:.|||.|:..||..|:|:|. :..|||:::
Mouse  1463 AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKNDANCDCYQS 1527

  Fly  2029 EHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNR 2093
            ....|..||.|..::||.:||..::|||..|.|||:|..:.|..:....||:.:|..||:|||:.
Mouse  1528 GDGYAKDAKLNAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDI 1592

  Fly  2094 FGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFLLRD---YTSQVNSIEN------ 2149
            .|.|..|.:::||:..|.|:|   :::..::.|||:.||.:.:.||   ...:|.|.:|      
Mouse  1593 NGTHQYTVSLVTGDYLYNFSY---SNDNDVTAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLT 1654

  Fly  2150 --TKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDSTGRSYVYNYDEFGRLTSAV 2212
              |.|  |...||...:  ||       |.:.|||.:|||.||.|.||.:..::||..||||:..
Mouse  1655 IGTNG--CLKSMTAQGL--EL-------VLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVT 1708

  Fly  2213 TPTGRVIELSFDLSVKGAQVKVSENAQKE-------MSLLIQGATVI---VRNGAAESRTTVDMD 2267
            .|||.|..|..|:. |...|.:..::::|       :|.:....|::   :||.     ..:..|
Mouse  1709 FPTGVVTNLHGDMD-KAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNS-----YQIGYD 1767

  Fly  2268 GSTTSITPWGHNLQMEVAPYTILAEQSPLLGESYPVPAKQRTEIAGDLA-NRFEWRYFVRRQQPL 2331
            ||.......|.:...:..|:.       |.|.:.|..||:...:.|:.. |..|||:  |::|  
Mouse  1768 GSLRIFYASGLDSHYQTEPHV-------LAGTANPTVAKRNMTLPGENGQNLVEWRF--RKEQ-- 1821

  Fly  2332 QAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQELLNVTYDRTSRPISFRP 2396
               .|.|     |...||||||||.|:|::::||.|::..:..|.::.||.:.||.:..|..:.|
Mouse  1822 ---AQGK-----VNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP 1878

  Fly  2397 QSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLPLKVT 2461
            .|...| |::.|...|::.|.:.|...|...:|..||:....:.||.|..|.:.:.  |:.|.:.
Mouse  1879 SSKLMA-VNVTYSSTGQIASIQRGTTSEKVDYDSQGRIVSRVFADGKTWSYTYLEK--SMVLLLH 1940

  Fly  2462 TPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEGQILAK 2526
            :.|:  |:.:||....|.::|.|....|......|:|:::..|..|.:.......||:||.:|..
Mouse  1941 SQRQ--YIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQT 2003

  Fly  2527 IHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKSVEVQEPGFELRREFKYHAGILKD 2591
            .....|.:|.|.:....||..||...:...:||.:|..::|:|.:|..||.....::....::..
Mouse  2004 AFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDR 2068

  Fly  2592 EKLRFGSKNSLASARYKYAYDGNARLSGIEMAIDDKELPTTRYKYSQNLGQLE-------VVQDL 2649
            :..|| |::.:.:||:.|:||.:.|::.::..|::..||...|::....|::|       :..|:
Mouse  2069 QIFRF-SEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDI 2132

  Fly  2650 KITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKNIDVFRLELDYDLRNRIKSQKTTFG- 2713
                |....|.:....|.|      |.|||:|.:...:....::.:.:.||...|:..::...| 
Mouse  2133 ----NQIISTAVMTYTKHF------DAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGP 2187

  Fly  2714 -RSTAFDKINYNADGHVVEVLGTNN--WKYLFDENGN--TVGVVDQGEKFNLGYDIGDRVIKVGD 2773
             .:|......|:.||.:..|.....  |:|.:|.|||  .:..........|.||:.||:.::||
Mouse  2188 FANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSSSARLTPLRYDLRDRITRLGD 2252

  Fly  2774 VEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERERFQSW---YYYDDRSRLVAWHDNKGNTTQY 2835
            |:: ..|..||:.:||.:.:.|:::|.|...:.:.  ..|   |.||...|.|:...:.|...|:
Mouse  2253 VQY-RLDEDGFLRQRGTEIFEYSSKGLLTRVYSKG--SGWTVIYRYDGLGRRVSSKTSLGQHLQF 2314

  Fly  2836 YYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALE-HEDQRYYVATDQNGSPLAFFDQNGSIV 2899
            :||:...|..:|||:....|....|:||.:..|.|:| .....:|:|:|..|:|||.|..||.::
Mouse  2315 FYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLML 2379

  Fly  2900 KEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQRQYDPHVGQWMTP---LWETLATE 2961
            |:::.|.:|.|..|:..:|.:.|.|||||.||.|||::..:|.||...|:|.||   :|:.:..:
Mouse  2380 KQIQYTAYGEIYFDSNVDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKD 2444

  Fly  2962 MSHPTDVFIYRYHNNDPINP-NKPQNYMIDLDSWLQLFGYDLNN-MQSSRYTKLAQYTPQASIKS 3024
               |....:|.:.||:|.:. :..::|:.|::|||..||:.|:| :......|.....|...:..
Mouse  2445 ---PAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVK 2506

  Fly  3025 NTLAPDFGVISGLECIVEKTSEKFSDFDFVPKPLLKMEPKMRNLLPRVSYR-------------- 3075
            :....|...|.|::..|.:.::.|....           ||..:  :||.|              
Mouse  2507 SQQWEDVPPIFGVQQQVARQAKAFLSLG-----------KMAEV--QVSRRKAGAEQSWLWFATV 2558

  Fly  3076 RGVFGEGVLLSRIGGRALVSVVDGSNSVVQDV--VSSVFNNSYFLD-LHFSIHDQDVFYFVKDNV 3137
            :.:.|:||:|:...||...:|::.:|   :|.  |::|.||:::|: |||:|..:|..||:|...
Mouse  2559 KSLIGKGVMLAVSQGRVQTNVLNIAN---EDCIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTT 2620

  Fly  3138 LKLRDDNEELRRLGG-----------------MFNISTHEISD---HGGSAAKELRLHGPDAVVI 3182
            .:  .|...||...|                 :.|..|...:|   ..|:    |.||       
Mouse  2621 PE--SDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGA----LALH------- 2672

  Fly  3183 IKYGVDPEQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEKEELVQHGDVDGWNGID 3247
            ::||:..::|:.|||:.|.:||:.|||..|:|.|..|.:|...|||.||.:|:..|.|.|::|..
Mouse  2673 VRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYY 2737

  Fly  3248 IHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            :.|:.:||:|||...|:.|.|.::..:|
Mouse  2738 VLSVEQYPELADSANNIQFLRQSEIGKR 2765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 64/128 (50%)
CRD2 1106..1151 CDD:276900 19/44 (43%)
EGF_2 1139..1162 CDD:285248 11/22 (50%)
Keratin_B2 1162..1330 CDD:279797 82/183 (45%)
EGF_2 1167..1194 CDD:285248 13/26 (50%)
DUF3844 1171..>1235 CDD:289707 27/63 (43%)
EGF_2 <1272..1294 CDD:285248 13/21 (62%)
NHL 1750..2065 CDD:302697 132/322 (41%)
NHL repeat 1784..1830 CDD:271320 16/45 (36%)
NHL repeat 1854..1888 CDD:271320 19/33 (58%)
NHL repeat 1911..1950 CDD:271320 16/38 (42%)
NHL repeat 1972..2005 CDD:271320 13/32 (41%)
NHL repeat 2039..2065 CDD:271320 12/25 (48%)
RHS_repeat 2183..2218 CDD:283287 17/34 (50%)
RhsA 2347..3020 CDD:225750 197/694 (28%)
YD_repeat_2x 2795..2836 CDD:273728 11/43 (26%)
Rhs_assc_core 2905..2980 CDD:274730 29/77 (38%)
Tox-GHH 3193..3268 CDD:292269 32/74 (43%)
Tenm3XP_036009877.1 Ten_N <192..351 CDD:399476 30/194 (15%)
exchanger_TraA <509..851 CDD:411343 151/346 (44%)
acid_disulf_rpt 835..865 CDD:411265 17/29 (59%)
NHL 1205..1564 CDD:302697 150/359 (42%)
NHL repeat 1234..1273 CDD:271320 21/38 (55%)
NHL repeat 1285..1328 CDD:271320 14/42 (33%)
NHL repeat 1352..1386 CDD:271320 19/33 (58%)
NHL repeat 1408..1447 CDD:271320 16/38 (42%)
NHL repeat 1470..1503 CDD:271320 13/32 (41%)
NHL 1536..>1632 CDD:302697 36/98 (37%)
NHL repeat 1538..1564 CDD:271320 12/25 (48%)
RhsA 1619..2480 CDD:225750 259/918 (28%)
Rhs_assc_core 2384..2458 CDD:274730 28/76 (37%)
Tox-GHH 2681..2758 CDD:406145 33/76 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837860
Domainoid 1 1.000 72 1.000 Domainoid score I9274
eggNOG 1 0.900 - - E1_KOG4659
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1463 1.000 Inparanoid score I112
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52630
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm43347
orthoMCL 1 0.900 - - OOG6_100953
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.770

Return to query results.
Submit another query.