DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ten-m and Wif1

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	XP_006241457.1	Gene:	Wif1 / 114557	RGDID:	619774	Length:	379	Species:	Rattus norvegicus

Alignment Length:	231	Identity:	71/231 - (30%)
Similarity:	90/231 - (38%)	Gaps:	53/231 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 VSLYNDDGD-----VQELTFYAAVAEDMTQNCPNGCSGNGQCLLGH-CQCNPGFGGDDCSESVCP 1103
            |.:.|.:|:     .|...|:....:   ..||.||...|.|.... |:|..||.|..|.:::|.
  Rat   154 VIVMNSEGNPILRTPQNAIFFKTCQQ---AECPGGCRNGGFCNERRVCECPDGFYGPHCEKALCI 215

  Fly  1104 VLCSQHGE-YTNGECICNPGWKGKECSLRHDECEVADCSGHGHC-VSGKCQCMRGYKGKFCEEVD 1166
            ..|...|. .|.|.|||.||:.|..|...:  |. |.|...|.| ..|||.|..|.:|:.||...
  Rat   216 PRCMNGGLCVTPGFCICPPGFYGVNCDKAN--CS-ATCFNGGTCFYPGKCICPPGLEGEQCELSK 277

  Fly  1167 CPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDD 1231
            ||.|              |:.|.|                 |.|       ...|.|...:.||.
  Rat   278 CPQP--------------CRNGGK-----------------CIG-------KSKCKCPKGYQGDL 304

  Fly  1232 CSKELCDLDCGQHGRC-EGDACACDPEWGGEYCNTR 1266
            |||.:|:..||.||.| |.:.|.|...|.|.:||.|
  Rat   305 CSKPVCEPGCGAHGTCHEPNKCQCREGWHGRHCNKR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	43/131 (33%)
		CRD2	1106..1151	CDD:276900	17/46 (37%)
		EGF_2	1139..1162	CDD:285248	9/23 (39%)
		Keratin_B2	1162..1330	CDD:279797	31/106 (29%)
		EGF_2	1167..1194	CDD:285248	6/26 (23%)
		DUF3844	1171..>1235	CDD:289707	11/63 (17%)
		EGF_2	<1272..1294	CDD:285248
		NHL	1750..2065	CDD:302697
		NHL repeat	1784..1830	CDD:271320
		NHL repeat	1854..1888	CDD:271320
		NHL repeat	1911..1950	CDD:271320
		NHL repeat	1972..2005	CDD:271320
		NHL repeat	2039..2065	CDD:271320
		RHS_repeat	2183..2218	CDD:283287
		RhsA	2347..3020	CDD:225750
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
Wif1	XP_006241457.1	FlaF	<10..57	CDD:299725
Wif1	XP_006241457.1	WIF	35..179	CDD:295401	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900