DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-m and tenm2

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:XP_012815129.1 Gene:tenm2 / 100486468 XenbaseID:XB-GENE-5799894 Length:2655 Species:Xenopus tropicalis


Alignment Length:2892 Identity:894/2892 - (30%)
Similarity:1430/2892 - (49%) Gaps:427/2892 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   572 QSDNSSSGPTPET--------TVRSDTDDIVEINTPPSQTAQRTFAAVSHQPAIEHDFQIKGTDA 628
            ||.|....||.||        ...|::..:.::.   |||..|......|.........|..|.:
 Frog     3 QSANKGRKPTAETGKESPNSKCCYSESGGVTKLG---SQTNSRYPKTPCHLDLYSEGRPIPSTSS 64

  Fly   629 GGLQTEKPATDDINNERDLADNYEVDSKEPTSPGTPPQGKVSQQTGKASLQSLQSESDLMMNDAS 693
            ..|..                    .::.|:|...||               :..:..|:.::.|
 Frog    65 SSLLP--------------------SAQLPSSHNPPP---------------VSCQMPLLDSNTS 94

  Fly   694 HYEDIDIVKLDGLTISHEEEIYKTADKENMAPKNQPSQHIDRSQNEVLKGHQQGDEKQPQLEPLK 758
            |                  :|..|...|..:    |:.::.|:    ..|.||.....|      
 Frog    95 H------------------QIMDTNPDEEFS----PNSYLLRA----CSGVQQASSSGP------ 127

  Fly   759 PYVSERVDLPGKRIFLNLTIATDEGSDSVYTLHVEVPTGGGPHFIKEVLTHEKPTAQA------- 816
                                 |:..|.|  ||...:|.... |.:...|:|...:|.:       
 Frog   128 ---------------------TNHHSQS--TLRPPLPPPHN-HTLSHTLSHHHSSANSLNKNSLT 168

  Fly   817 --DSCVPEPPPRMPDCPCSCLPPPAPIYLDDTVDIDSAPPAKT----VTTSTISAPINPFHSEEE 875
              .:.:..|.|    .|......|..:.|.|:..::|..|.:|    ..||:.:.|:        
 Frog   169 NRRNQIHAPAP----APNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGTTPL-------- 221

  Fly   876 DDEDGVRDEEQTPSSSTATNLPSTEIDNHIAAFTEPAVGAGGVPFACPDVMPVLILEGARTFPAR 940
                         .||::...|.|.    ...:|.|           |.::|      ..||...
 Frog   222 -------------FSSSSPGYPLTS----GTVYTPP-----------PRLLP------RNTFSRN 252

  Fly   941 SF---------------------------------------------PPDGTTF----------- 949
            :|                                             |.||.||           
 Frog   253 AFKLKKPSKYCSWKCAALSAIAAAILLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGTEDV 317

  Fly   950 ---------------------GQITLGQKLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIG 993
                                 |:|.:|:::|:|:....:|....:.::|.::||:.::.:.|..|
 Frog   318 ATMPSGGKGPWITTKNSSIDTGEIEIGRRITQEVLAGVFWRSHIHITQPQFLKFNISLGKDALFG 382

  Fly   994 VYGRRNALPTHTQYHFKEVLSG-----FSASTRTARAAHLSITREV--TRYMEPGHWFVSLYNDD 1051
            ||.||...|:|.||.|.|.|.|     ...|.|..|:....:..|.  .:|::.|.|.::.|||.
 Frog   383 VYMRRGLAPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGFWHLAFYNDG 447

  Fly  1052 GDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGE 1116
            .| :|:..::.|..|..|:||..|.|||:|:.|.|.|.|||.|.||:::.||||||.:|:|:.|.
 Frog   448 KD-KEIVSFSTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFHGADCAKAACPVLCSGNGQYSKGT 511

  Fly  1117 CICNPGWKGKECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADG 1181
            |||..||||.||.:...:|....|.|||.|:.|.|.|..|:||..|:||||..|.||.||.|.:|
 Frog   512 CICYSGWKGAECDIPISQCIDPSCGGHGSCIEGNCICAVGFKGDNCDEVDCMDPTCSNHGVCVNG 576

  Fly  1182 TCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGR 1246
            .|:|..||.|.:|   :....||...||||||:..||..|:|:..|.|.|||.|:|.:|||.||.
 Frog   577 ECLCSPGWGGQNC---ELPRTQCPDQCSGHGTYLTDTGLCSCDPNWMGPDCSVEVCSVDCGTHGV 638

  Fly  1247 CEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRV 1311
            |.|.||.|:..|.|..|:.|:|..||.|||.||:|.|.|..||||:||||:|||:.|.|:|:|.:
 Frog   639 CIGGACRCEEGWTGVACDQRVCHPRCTEHGTCKDGKCDCKEGWNGEHCTIDGCPDLCNGNGRCTL 703

  Fly  1312 SGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPI 1376
             |:..|:|.|..||.|..|.:|:|.:|.|:|||:.||||||.||:||....|::|.||..:..|:
 Frog   704 -GQNSWQCICQTGWRGSGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSTCQSSLLCRGSRDPL 767

  Fly  1377 DVLLRKQPPAITA-SFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTSLGM 1440
            |::.:.|..:.|. ||::|:|.|:.:.|.....     .|    |.||:|..::|||:|||..|.
 Frog   768 DIIQQSQTDSPTVKSFYDRIKLLVGKDSTHIIP-----GE----NPFNSSLVSLIRGQVVTIDGT 823

  Fly  1441 GLVGVRVSTTTLLE-GFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQSRIVQVPWNEVVIIDLV 1504
            .||||.||.....: |:|:||.||.|||:.|||.::||.|.||||..|.|.|.:|||....:|.:
 Frog   824 PLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYALDTL 888

  Fly  1505 VMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTG 1569
            .|. :||..:.     :|....:....||:::|....|..:.|.|:.|:.|:||:.|.:::||..
 Frog   889 AMK-TEENSIP-----SCDLSGFVRPDPVIISSPLSTFFSSSPSRNPIVPETQVLHEEIELPGYS 947

  Fly  1570 LNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNI 1634
            :.|.|.|||.:||.|.:|:.:|..::|.:|..:||.:.:||.||::.|:|.|.:.:|:.|::.:.
 Frog   948 MKLCYLSSRTSGYKSLLKITMTQSMVPLNLLKVHLMVAVEGHLFQKTFQASPNLAYTFVWDKNDA 1012

  Fly  1635 YRQRVYGVTTAVVKVGYQYTDCTD-IVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGILQK 1698
            |.|||||::.|||.||::|..|.. |:|:.:|..|.|.::..|.:|||:||.||..|...|||.|
 Frog  1013 YGQRVYGLSDAVVSVGFEYETCLGLILWEKRTAILQGFELDPSNLGGWSLDKHHVLNIRSGILHK 1077

  Fly  1699 GDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVGDFNYIRR 1763
            |.|.|.:|..:|.:|.:.||:|.:|.:.||.|:|.|...:||||||||.:.||||||||.|:|||
 Frog  1078 GSGENQFLSQQPAVITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVSIDGSLFVGDVNFIRR 1142

  Fly  1764 IMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQPELNW 1822
            |....::.::::|      ::..::::|::|:.|:.|:||:||..|.:|.:::......:...|.
 Frog  1143 IFPSRNVTSILELRNKEFKHSNNIAHKYYLAVDPVSGSLYLSDTNSRRIYKIKSLTGAKELATNL 1207

  Fly  1823 EAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVSTLIG 1887
            |.:.|:||:|:|.|||.||:|..|.||.|..|:|||:....::||.|.|.||.||::||:|||:|
 Frog  1208 EVIAGNGEQCMPFDEARCGNGGKAVDAILTNPRGIAVDKYGLIYFVDATMIRKVDQNGIISTLLG 1272

  Fly  1888 NHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPDGRVRVISGRPLH 1952
            :: ..:..:|:.|:.::.:.::.:.|||:|||:||||:|:::::::|||:|.:.:|.:|:|||:|
 Frog  1273 SN-DLAAGRPLSCDSSMDITQVRMEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMH 1336

  Fly  1953 CATASTAYD-TDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESKC 2016
            |......|. :.||.|:.|....:||....|.||:||::.::|||:|.:.|:|.|:..|||.|.|
 Frog  1337 CQVPGIDYSLSKLAIHSALESASAIAVSHTGILYIAETNEKKINRIRQVTTNGEISLLAGAPSDC 1401

  Fly  2017 NCLER-GCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEASPSREYEI 2080
            ||.:. .|:|:..:...||.|..|:.::|||.||..|:|||..|.|||:|:.:.|..:...:||:
 Frog  1402 NCKDDVNCNCYAGDDGYATDAFLNSPSSLAVAPDGTVYIADLGNIRIRAVLQNKPVLTSFNQYEV 1466

  Fly  2081 YAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFLLRDYTSQVN 2145
            .:|..||:||||..|.|..|::::|||..|.|||   ::...::.|.|.:||.:.:.||......
 Frog  1467 ASPGEQELYIFNANGIHQYTQSLVTGEYLYNFTY---SAENDVTEVIDNSGNSLKVRRDTNGTPR 1528

  Fly  2146 SIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDSTGRSYVYNYDEFGRLTS 2210
            .|.....|...|.:|....|..:||.........|.|..|||.||.|.||.:..|:||..||||:
 Frog  1529 HILMPDNQIITLTLTANGGLKSVSTQSLELALMTYDGTNGLLTTKSDETGWTTFYDYDNEGRLTN 1593

  Fly  2211 AVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTVDMD-------- 2267
            ...|||.|..|..::. |...:.: ||:.::     ...|||....:.|:..||..|        
 Frog  1594 VTRPTGVVTSLHREME-KSITIDI-ENSNRD-----DDVTVITNLSSVEASYTVVQDQVRNSYQL 1651

  Fly  2268 ---GSTTSITPWGHNLQMEVAPYTILAEQSPLLGE---SYPVPAKQRTEIAGDLANRFEWRYFVR 2326
               |:...:...|..:.....|:.:....:|.:|.   |.|:.         :..|..|||  :|
 Frog  1652 CSNGTLRVMYANGMGISFHSEPHILAGTVTPTIGRRNISLPME---------NGLNSIEWR--LR 1705

  Fly  2327 RQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQELLNVTYDRTSRP 2391
            ::       |:||   .||..||||||:|.|:|::::||.:.:..:..|.::..|.:.||:..||
 Frog  1706 KE-------QTKG---KVTVFGRKLRVHGRNLLSIDFDRNSHTEKIYDDHRKFTLRIVYDQLGRP 1760

  Fly  2392 ISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSL 2456
            :.:.|.|| .|.|::.|...|||...:.|.:.|....|:.||:....:.||....|.:.:.  |:
 Frog  1761 LLWLPSSG-LAPVNVSYFFNGRLAGLQRGAMSERTEMDKQGRIISRSFADGKVWSYTYLEK--SM 1822

  Fly  2457 PLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEG 2521
            .|.:.:.|:  |:.:||.:..|.::|.|....|:.|..||:|:.:..|..|.:.......|:::|
 Frog  1823 VLLLQSQRQ--YIFEYDPSDRLYAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASIMFDYSEDG 1885

  Fly  2522 QILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKSVEVQEPGFELRREFKYHA 2586
            :||.........:|.:.:....:|..|:...::..:.|.:||.::|.|.:|..||.....:: ..
 Frog  1886 RILKTSFLGTGRQVFYRYGKLSKLSEIIYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYR-KI 1949

  Fly  2587 GILKDEKLRFGSKNSLASARYKYAY-DGNARLSGIEMAIDDKELPTTRYKYSQNLGQLE------ 2644
            |.|.|:::...|:..:.:||:.|.| |.:.|::.|:..|.:..||...|:|....|::|      
 Frog  1950 GPLVDKQIYRFSEEGMVNARFDYTYHDNSFRVASIKPIISETPLPVELYRYDDISGKIEHFGKFG 2014

  Fly  2645 -VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKNIDVFRLELDYDLRNRIKSQ 2708
             :..|:    |....|.:....|.|      |.|||:|.|...:....::.:.:.||...|:..:
 Frog  2015 VIYYDV----NQIITTAVMTLTKHF------DTHGRIKEVQYEIFRSLMYWMTVQYDSMGRVTKR 2069

  Fly  2709 KTTFGRSTAFDKINYNADG----HVVEVLGTNNWKYLFDENGNTVGVVDQGEK---FNLGYDIGD 2766
            :...|......|..|..||    ..|.|.....|:|.:|.||| :.:::.|..   ..|.||:.|
 Frog  2070 ELKLGPYANTTKYTYEYDGDGQLQSVSVNDRPTWRYSYDLNGN-LHLLNPGNSARLMPLRYDLRD 2133

  Fly  2767 RVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERERFQSW---YYYDDRSRLVAWHDN 2828
            |:.::|||:: ..|..||:.:||...|.||::|.|..::  .:...|   |.||...|..:...|
 Frog  2134 RITRLGDVQY-KIDDDGFLCQRGADIYEYNSKGLLTRAY--NKVNGWNIQYRYDGLGRRASIKTN 2195

  Fly  2829 KGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALEHED-QRYYVATDQNGSPLAFF 2892
            .|...|::||:...|..||||:....|....|:||.:..|.|:|... :.||:|:|..|:|||.|
 Frog  2196 LGLHLQFFYADLHNPTRVTHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYIASDNTGTPLAAF 2260

  Fly  2893 DQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQRQYDPHVGQWMTP---L 2954
            ..||.::|:::.|.:|.|..|:.|.|.:.|.|||||.||.||||:..||.||...|:|::|   :
 Frog  2261 SINGVMIKQLQYTAYGEIYFDSNPNFQLVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWISPDYTM 2325

  Fly  2955 WETLATEMSHPTDVFIYRYHNNDPINPNKP-QNYMIDLDSWLQLFGYDLNNM-----QSSRYTKL 3013
            |:.:..:   |....:|.:.||:|::.... :||:.|:.|||.:||:.|:|:     :|..|...
 Frog  2326 WKKIGRD---PAPFNLYMFKNNNPLSTEMDLKNYVTDVQSWLVMFGFQLSNIIPGFPRSRMYFVP 2387

  Fly  3014 AQY--TPQASIKSNTLAPDFGVISGLECIVEKTSEKFSDFDFVPKPLLKMEPKMRNLLPRVSYRR 3076
            |.|  |.....::..|      |:|::...|:.::.|.        .|:.:..::.|...:..:.
 Frog  2388 APYELTESQECENGQL------ITGVQQTTERHNQAFM--------ALEGQTIVKRLHSSIREKP 2438

  Fly  3077 G--------VFGEGVLLSRIGGRALVSVVDGSNSVVQDVVSSVFNNSYFLD-LHFSIHDQDVFYF 3132
            |        :.|:|::.:...|:...::...||...:. ::.|.|::::|: ::::|..:|..||
 Frog  2439 GHWFATTVPIIGKGIMFAIKEGKVTTAISSISNEDSRK-IALVLNSAHYLEKMYYNIEGKDTHYF 2502

  Fly  3133 VKDNVLKLRDDNEELRRLGGMFNIST-HEISDHGGS---AAKELRLHG------------PDAVV 3181
            |     |:...:.:|..||    :|| .:..|:|.:   :...|.::|            ...::
 Frog  2503 V-----KIGSSDSDLVTLG----VSTGRKTLDNGVNVTVSQPTLLINGRTRRFTNIEFQHSSLLL 2558

  Fly  3182 IIKYG--VDP-EQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEKEELVQHGDVDGW 3243
            .::||  :|. ::||.|:|..|.:||:..||..|:|....|.:|...|||.||::|:..|.|.|:
 Frog  2559 NVRYGLTIDTLDEERARVLDQARQRALAAAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGY 2623

  Fly  3244 NGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            .|..:..:.:||:|||...|:.|.|..:..:|
 Frog  2624 EGYYVLPVEQYPELADSSSNIQFLRQNEMGKR 2655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 65/128 (51%)
CRD2 1106..1151 CDD:276900 21/44 (48%)
EGF_2 1139..1162 CDD:285248 11/22 (50%)
Keratin_B2 1162..1330 CDD:279797 84/167 (50%)
EGF_2 1167..1194 CDD:285248 13/26 (50%)
DUF3844 1171..>1235 CDD:289707 29/63 (46%)
EGF_2 <1272..1294 CDD:285248 13/21 (62%)
NHL 1750..2065 CDD:302697 128/322 (40%)
NHL repeat 1784..1830 CDD:271320 13/45 (29%)
NHL repeat 1854..1888 CDD:271320 17/33 (52%)
NHL repeat 1911..1950 CDD:271320 18/38 (47%)
NHL repeat 1972..2005 CDD:271320 12/32 (38%)
NHL repeat 2039..2065 CDD:271320 14/25 (56%)
RHS_repeat 2183..2218 CDD:283287 18/34 (53%)
RhsA 2347..3020 CDD:225750 209/702 (30%)
YD_repeat_2x 2795..2836 CDD:273728 12/43 (28%)
Rhs_assc_core 2905..2980 CDD:274730 31/77 (40%)
Tox-GHH 3193..3268 CDD:292269 29/74 (39%)
tenm2XP_012815129.1 Rhs_assc_core 2272..2348 CDD:274730 31/78 (40%)
Tox-GHH <2591..2648 CDD:292269 21/56 (38%)
Ten_N <28..266 CDD:284015 57/377 (15%)
EGF_2 <470..492 CDD:285248 12/21 (57%)
EGF_CA <567..590 CDD:238011 12/25 (48%)
EGF_2 597..624 CDD:285248 12/26 (46%)
DSL <645..686 CDD:302925 20/40 (50%)
NHL 1121..1451 CDD:302697 133/330 (40%)
NHL repeat 1121..1160 CDD:271320 19/38 (50%)
NHL repeat 1172..1215 CDD:271320 12/42 (29%)
NHL repeat 1239..1273 CDD:271320 17/33 (52%)
NHL repeat 1295..1334 CDD:271320 18/38 (47%)
NHL repeat 1357..1390 CDD:271320 12/32 (38%)
NHL repeat 1425..1451 CDD:271320 14/25 (56%)
RHS_repeat 1563..1601 CDD:283287 20/37 (54%)
RhsA 1570..2335 CDD:225750 235/815 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1040 1.000 Domainoid score I29
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H22672
Inparanoid 1 1.050 1451 1.000 Inparanoid score I118
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm48494
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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