DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ten-m and tnca

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:XP_021332057.1 Gene:tnca / 100149028 ZFINID:ZDB-GENE-130530-849 Length:2336 Species:Danio rerio


Alignment Length:2472 Identity:507/2472 - (20%)
Similarity:818/2472 - (33%) Gaps:801/2472 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1070 NCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDE 1134
            :||..||..|:|:.|.|:|..||.|||||...|.:.|..:|...||:|:|:.|:.|:.|:  ..:
Zfish   190 DCPGDCSDQGRCVNGKCECFEGFTGDDCSTDACLIDCGDNGRCLNGKCVCSEGFSGEYCT--ESD 252

  Fly  1135 CEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQ 1199
            | :.:|.|.|.||.|:|.|...:.|..|.|:.||: :|...|.|.:|||.|.:|:.|.||.    
Zfish   253 C-LNNCLGRGRCVDGECVCDEPWTGFDCSELICPN-DCYDRGRCENGTCYCDRGFTGEDCG---- 311

  Fly  1200 DALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCN 1264
             ||.|..||||.| |.:|.: |.|:|.::|:|||...|..:|...|||....|.|:..:.||.|.
Zfish   312 -ALACPNDCSGRG-FCIDGR-CVCDAGYTGEDCSSLTCPNNCNDRGRCSNGVCICEVGFHGEDCG 373

  Fly  1265 TRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPD 1329
            ...|...||..|.|.:|.|.|..|:.|..|:...|||:|...|:| |:|    :|.|.||:...|
Zfish   374 RISCPSNCNNRGHCVDGRCECDVGFQGHDCSELSCPNNCNNRGRC-VNG----QCVCDEGFGSED 433

  Fly  1330 CGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPIDVLLRKQPPAITASFF-E 1393
            ||:.   .|    .:|..|...|.|.||    ||                        .|:|. |
Zfish   434 CGLK---TC----PSDCYGRGQCVDGEC----VC------------------------FANFAGE 463

  Fly  1394 RMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTSLGMGLVGVRVSTTTLLEGFT- 1457
            ....|...:|.||                   |...|.|:.|..                |||| 
Zfish   464 DCSELRCPNSCQN-------------------RGRCIAGQCVCD----------------EGFTG 493

  Fly  1458 --LTRDDGWFDLMVNG---GGAVTLQFGRAPFRPQS-RIVQVPWNEVVIIDLVVMSMSEEKGLAV 1516
              .::.....|.:..|   .|....|.|   |:.|. .:...|.|            ..:.|..|
Zfish   494 EDCSQRKCPNDCLGRGRCVDGRCVCQDG---FKGQDCSVPTCPGN------------CNDHGRCV 543

  Fly  1517 TTTHTCFAHDYDLMKPVVLASWKHGFQG-ACPDRSAILAESQVIQ-------------------- 1560
            .....|                ..||.| ||.|||.:...|.|.|                    
Zfish   544 NGKCVC----------------DEGFFGDACSDRSCLNDCSDVGQCVDGRCICDEGYIGEDCSDV 592

  Fly  1561 ---ESLQIPGTG---LNLVYHSSR-AAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFER--- 1615
               |.|.:....   :||.:.:.. ...||.|        .:||:...:.:...:.|   :|   
Zfish   593 SPPEDLTVTDVSTQKVNLTWRNEMLVTEYLIT--------YVPTAPGGLQMDFRVAG---DRTSA 646

  Fly  1616 -IFEADPGIKFTYAWNRLNIY----RQRVYGVTTAVVKV-----GYQYTDCTD----IVWDIQTT 1666
             :.|.:|||::.     :|:|    .:|...|:..|...     |.::|..||    :||:....
Zfish   647 TVSELEPGIEYL-----INVYAVLNNKRSIPVSARVATYLPQPEGLRFTSITDSTVEVVWEQLNF 706

  Fly  1667 KLSGHDMSISEVGGWNLDIHH-----RYNFHEGILQKGDGSNIYL---RNKPR------IILTTM 1717
            ...|.::........|..|.:     :..|.:..|..|....:.|   :|..|      .::|.:
Zfish   707 PFDGWELIFRNTKEENGKIVNNLTPSQTTFEQQGLGPGQEYEVTLSVIKNNTRGPETSSTVVTRI 771

  Fly  1718 GDGHQRPLECPDCDGQA---TKQRLLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKLNAT 1779
            ....|  :|..|...::   :..:.||||      ||      |.......||..|...|:|:|:
Zfish   772 DSPAQ--IEVADVTDRSAVISWSKPLAPV------DG------FKVSYGPSTDPLIHRDVELSAS 822

  Fly  1780 RVSY---------RYHMALSPLDGTLYVSDP---------ESHQIIRVRDTNDYSQPELNWEAVV 1826
            ...|         :|.:|||...|.: .|:|         ::...:|..|..| |...|.|:...
Zfish   823 ETQYSLEDLKPDTQYRVALSSQRGDV-TSEPIIESFTTGLDAPSELRAVDQTD-SSITLEWKNSR 885

  Fly  1827 GS--GERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVSTLIGNH 1889
            .|  |.|...|..|   .||..:|   .:||....::     :|..|.::.....||..|.:.|.
Zfish   886 SSIDGYRIKYGPIA---GGAHGED---MFPKKAGDTT-----WATITGLKPGTEYGIGVTAVQNE 939

  Fly  1890 MHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPDGRVRVISGRPLHCA 1954
            ...   :|........|:.     |.:|.|.....|                .|.::..||.  |
Zfish   940 RES---EPATTNALTDLDP-----PRDLEVQSSTET----------------SVDLVWKRPR--A 978

  Fly  1955 TASTAYDTDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESKCNCL 2019
            ..||                                    .|:..:..:||              
Zfish   979 KIST------------------------------------YRLAYVSVEGR-------------- 993

  Fly  2020 ERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEASPSREYEIYAPD 2084
                   ..|..|..||..:|::.|.......|.:..:..:| ||..:::..::.|..:      
Zfish   994 -------REEIELPASASTSTLSGLMPGMSYTVTLVAERGHR-RSAPATVTASTASFTF------ 1044

  Fly  2085 MQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTS-NGKLSTVTDAAGNKVFLLRDYTSQVNSIE 2148
                |:.|.|.:..|.:.......::|...|..|. :|  |.:.|..|...           :|.
Zfish  1045 ----YLANAFPEFGSAKGADDNIISFVSLENSETPFSG--SGLEDPIGGSF-----------TIS 1092

  Fly  2149 NTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDSTGRSYVYNYDEFGRLTSAVT 2213
            |.......|    |...::||..|::  |.|....:|:.:.::...|:..               
Zfish  1093 NVSSHGFDL----MWDSNKLSGFDSF--TVEVTDFSGMWKEEVHLNGKVN--------------- 1136

  Fly  2214 PTGRVIELSFDLSVKGA------QVKVSENAQKEMSLLIQGATVIVRNGAAESRTTVDMDGSTTS 2272
                      |..::|.      ||::...:..:.|.|::...|     .|...|:.|:...|..
Zfish  1137 ----------DTKIRGLKSSTEYQVRLYGLSNNQRSSLLEAVAV-----TAPKSTSPDVVALTVK 1186

  Fly  2273 ITPWGHNLQMEVAPYTILAEQSPLLGESYPVPAKQRTEIAGDLANRFEWRYFVRRQQPLQA---- 2333
            ..   ...|..|:..|:|.|.   .....|:...:.||: |..:.|..|      |.|.:|    
Zfish  1187 RV---SAAQPSVSTSTLLTED---FKAEEPLSDLKVTEV-GANSLRLSW------QAPERAFSSF 1238

  Fly  2334 -------GKQSKGPPRPVTEVGRKLRVNGDNV-----LTLEYDR----ETQSVVVMVDDKQELLN 2382
                   ...||.....|:...|...|.|.|.     :|| |.|    ::|.:.|.|..:::   
Zfish  1239 IIELNSTSNTSKDSIIKVSGEARHAHVEGLNADMNYEITL-YGRKAGEKSQPISVFVKTEEQ--- 1299

  Fly  2383 VTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFD------RNG----RLNEI 2437
                        :||.|..:..|:.:|.|.  |||   ::::..:||      .|.    |.|..
Zfish  1300 ------------KPQIGSLSLSDVSWDSFN--VSW---IIEDGPAFDSFVIEVANSAGPERQNLS 1347

  Fly  2438 KYGDG------------STMVYAF----KDMFGSLPLKVTTPRR----SDYLLQYDDAGALQSLT 2482
            ..||.            |.|:..:    ..:.||:.::..|.|.    :.|:..........|..
Zfish  1348 VSGDARDLWMSGLSPGTSYMITLYGVHQGSILGSINVEAATDRAPAMGNLYVSNVTSQSFFVSWN 1412

  Fly  2483 TPRGHIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEGQI----LAKIHP-------------- 2529
            ..:|.|..|.|:.        ..|...:.|.|  ||....:    :..:.|              
Zfish  1413 DTKGEIERFVLEI--------IDSSWQQEPIE--YNLSQSVQSYEITGLRPTTDYIAYVTGVMKG 1467

  Fly  2530 HQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSL-----VKS-----VEVQEPGFELRREFK- 2583
            .::..|:.|..||.  |..|:||..::.| .|:.||     .|:     |||:|.....:...: 
Zfish  1468 RRTDSVSAVASTAA--EPDLSGLVVSNVT-SDSVSLSWRTGEKAFDNFIVEVRESALPSQASGRT 1529

  Fly  2584 YHAGILKDEKLRFGSKNSL-ASARYK---YAYDGNARLSGIEMAIDDKELPTT-RYKYSQNLG-- 2641
            :.||:      |....|.| .:..|:   ||....|....:...:..:..|.. |...|:.|.  
Zfish  1530 FGAGV------RSAVLNGLRGNTTYQIKLYATVAGANTDALTTVVTTEPKPELGRVVVSERLANS 1588

  Fly  2642 -----------------------QLEVVQDLKITRNAFNRTV--IQDSAKQFFAIVDYD-QHGR- 2679
                                   ||..|.:|:::....|.:|  :.||.  .:.|:.|. .||| 
Zfish  1589 LTLSWSTLSGHFDGFAARVSDREQLYDVVELRLSGTERNTSVQGLVDST--VYDIMFYGVSHGRQ 1651

  Fly  2680 VKSVLMNVKNIDVFRLELDYDLRNRIKSQKTTFGRSTAFDKINYNADGHVVEVLGTNNWKYLFDE 2744
            ..||..|.....:.::|      |......|.:|     .:::::||.      |.::::....:
Zfish  1652 TPSVYFNTSTASLPKVE------NLTVWDVTPYG-----FRVSWDADS------GFSHFQVKVSD 1699

  Fly  2745 NGNTV---GVVDQGEKFNL---------GYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNN 2797
            :|..:   .:|..|.:.:|         ||::.  |..|......:.......|...|.:..:  
Zfish  1700 SGQLLEPQELVVPGNEASLEVLGLITGIGYEVS--VTGVSGTGLRSRPITTVAVTEAEPEIEH-- 1760

  Fly  2798 RGQLIHSFERERFQ-SWYYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLF 2861
              ..:.....|.|: ||...||             ....:....|....::|      .|...:.
Zfish  1761 --LFVSDVTPESFRLSWTTEDD-------------VFDRFVLKVRDSRKLSH------PREFSMS 1804

  Fly  2862 YDDR-----DMLIALEHEDQRYYVATDQNGSPLAFFDQNGSIVKEMKRTPFGRI-------IKDT 2914
            .|:|     .:|...|:|.:.|.|..::...|:.      ::||    |..|.:       |.||
Zfish  1805 GDERTKVLTQLLGGTEYEIELYGVTLERRSQPVT------AVVK----TGLGALRDLHFSDITDT 1859

  Fly  2915 -----------KPEFF----VPIDFHGGLIDPHTKLVYTEQRQ-----------YDPHV----G- 2948
                       :|:.:    :||  .||  .|....|...|.|           |...|    | 
Zfish  1860 SAVVYWTLPRAQPDSYRITLIPI--QGG--SPMIVQVDGSQSQVSLRNLIPGETYQVSVIAVKGL 1920

  Fly  2949 QWMTPLWETLATEMSHPTDVFIYRYHNNDPINPNKPQNYMIDLDSWLQLFGYDLNNMQSSRYTKL 3013
            :...|:.:|..|.:..|..:.:....::..:...:|....:|        ||             
Zfish  1921 EESEPVSDTFTTALDTPRSLTVVNVTDSSALLFWQPAVATVD--------GY------------- 1964

  Fly  3014 AQYTPQASIKSNTLAPDFGVISGLECIVEKTSEKFSDFDFVPKPLLKMEPKMRNLLPRVSYRRGV 3078
                 ..:..::|:.|          |.|:.|....:|:            |.:|.|...|...|
Zfish  1965 -----MITYSADTVPP----------ISEQVSGNTVEFE------------MNSLAPATQYTVSV 2002

  Fly  3079 FGEGVLLSRIGGRALVSVVDGSNSV--VQDVV-SSVFNNSYFLD------------LHFSIHDQD 3128
            :.     .|...::|.:..|.:..|  .:|:| |::..:|..|.            |.|...|.|
Zfish  2003 YA-----IRDREKSLPATADFTTDVDAPRDLVASNIQTDSAVLSWTPPRAAITGYTLTFQNSDAD 2062

  Fly  3129 VFYFVKDNVLKLRDDNEELRRLGGMFNISTHEISDHGGSAAKELRLHGPDAVVIIKYGVDPEQER 3193
            |...:.|.                  ::::|.:|:          |.......:|...|. |.:|
Zfish  2063 VREVIVDP------------------SVASHTLSN----------LRSTTKYTVILQAVS-EDKR 2098

  Fly  3194 HRILK---------HAHKRAVERAWELEKQLVAAGFQGRGDWT----EEEKEELVQHGDV----D 3241
            .|.:.         :.|.|....|       :..|....|.:|    .:||:.|..:.|:    .
Zfish  2099 SRSISTEFTTVGMLYGHPRDCSEA-------LLNGETSSGPYTIYINGDEKQPLRVYCDMTTDGG 2156

  Fly  3242 GW 3243
            ||
Zfish  2157 GW 2158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 51/127 (40%)
CRD2 1106..1151 CDD:276900 16/44 (36%)
EGF_2 1139..1162 CDD:285248 9/22 (41%)
Keratin_B2 1162..1330 CDD:279797 65/167 (39%)
EGF_2 1167..1194 CDD:285248 11/26 (42%)
DUF3844 1171..>1235 CDD:289707 28/63 (44%)
EGF_2 <1272..1294 CDD:285248 9/21 (43%)
NHL 1750..2065 CDD:302697 63/334 (19%)
NHL repeat 1784..1830 CDD:271320 14/56 (25%)
NHL repeat 1854..1888 CDD:271320 7/33 (21%)
NHL repeat 1911..1950 CDD:271320 5/38 (13%)
NHL repeat 1972..2005 CDD:271320 1/32 (3%)
NHL repeat 2039..2065 CDD:271320 5/25 (20%)
RHS_repeat 2183..2218 CDD:283287 2/34 (6%)
RhsA 2347..3020 CDD:225750 152/830 (18%)
YD_repeat_2x 2795..2836 CDD:273728 6/41 (15%)
Rhs_assc_core 2905..2980 CDD:274730 21/112 (19%)
Tox-GHH 3193..3268 CDD:292269 14/68 (21%)
tncaXP_021332057.1 EGF_2 189..217 CDD:285248 13/26 (50%)
EGF_2 316..341 CDD:285248 11/26 (42%)
EGF_2 377..403 CDD:285248 10/25 (40%)
EGF_2 408..434 CDD:285248 12/30 (40%)
EGF_2 470..496 CDD:285248 11/60 (18%)
EGF_2 496..527 CDD:285248 7/33 (21%)
EGF_2 530..558 CDD:285248 8/55 (15%)
FN3 593..679 CDD:238020 20/101 (20%)
fn3 682..763 CDD:306538 15/80 (19%)
fn3 772..852 CDD:306538 23/94 (24%)
FN3 862..947 CDD:238020 23/99 (23%)
FN3 954..1036 CDD:238020 23/162 (14%)
FN3 1087..1171 CDD:238020 18/130 (14%)
fn3 1210..1289 CDD:306538 20/86 (23%)
fn3 1301..1376 CDD:306538 18/79 (23%)
fn3 1392..1464 CDD:306538 12/81 (15%)
FN3 1486..1570 CDD:238020 20/90 (22%)
fn3 1574..1649 CDD:306538 14/76 (18%)
fn3 1665..1740 CDD:306538 15/93 (16%)
fn3 1756..1829 CDD:306538 15/95 (16%)
fn3 1846..1925 CDD:306538 16/82 (20%)
fn3 1935..2013 CDD:306538 17/130 (13%)
fn3 2023..2096 CDD:306538 16/101 (16%)
FReD 2114..2323 CDD:238040 12/52 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.