DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hem and Nckap1

DIOPT Version :9

Sequence 1:	NP_524214.1	Gene:	Hem / 40462	FlyBaseID:	FBgn0011771	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_038961669.1	Gene:	Nckap1 / 58823	RGDID:	61939	Length:	1134	Species:	Rattus norvegicus

Alignment Length:	1135	Identity:	676/1135 - (59%)
Similarity:	866/1135 - (76%)	Gaps:	24/1135 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARPIF-PNQQKIAEKLIILNDRGLGILTRIYNIK------KACGDTKSKPGFLSEKSLESSIKF 58
            |:|.:. |:|||:||||.||||||:|:|||:||||      |||||.|:||.:|.:|:|||::||
  Rat     1 MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKQGQVWKACGDPKAKPSYLIDKNLESAVKF 65

  Fly    59 IVKRFPNIDVKGLN----AIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDIT 119
            ||::||.::.:..|    .:...|:||:|:|:|||.||||:::|||:||:||.|:|.||:..|||
  Rat    66 IVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCDLLNTIDVCQVFFDIT 130

  Fly   120 LNFELTKYYLDLVVTYVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPL 184
            :||:|||.||||.|||.:|||:|||:|:|||::||||.|:|:.:..:|..:|||||||:|||.||
  Rat   131 VNFDLTKNYLDLTVTYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYEHPL 195

  Fly   185 KKLAEEFIPHQRLLTSALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYIS 249
            ||:.|||:||.:.|:.||.||..:|..|||.||:||..|.|||:..|:.:|...::|||.|||:|
  Rat   196 KKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLS 260

  Fly   250 LEAMDRWIIFGLLLNHQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSK 314
            |:||::|||||.:|.|.||........:|..||:||..::||||||..||:..:..|..|:||:|
  Rat   261 LDAMEKWIIFGFILCHGMLNTEATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNK 325

  Fly   315 RIGEVKEAYNTAVQKAALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILW 379
            ||.:::|....||..|..||||||||||:||||||.:::||||||||||:|:|:.|..|||||:|
  Rat   326 RINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIW 390

  Fly   380 LLRHNDNPPLLKNKGKSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNI 444
            ||||.||.|     .||.:|.:|:.:.||:|:||||||.||||..|||||||||||||||..||.
  Rat   391 LLRHADNMP-----KKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNE 450

  Fly   445 RMQSLQMCPEDESIIFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEH 509
            .:|:|.:||||||||.||..||..:|:||||||.|:|.||..||||||||.|.||.||:|.:|:|
  Rat   451 LVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLADH 515

  Fly   510 AELARLLDSMVFHTRVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICS 574
            .||.:::::::|||::||:|.|:|||||||||||||::.|:..|..|||.|:|:||.|||||:|:
  Rat   516 RELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCT 580

  Fly   575 HFQNCTHEMCPEERHHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSV 639
            ||.:||||:||||||||.:||||:.|:||:||||:|:|:||.||.||||::|.||||||||.:|
  Rat   581 HFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTIS- 644

  Fly   640 QSARKKKDKSKSKHFDDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFA 703
            |:..||..|...|..:..| |||.||.||.|..:|.:||||.||:||||:|||.|.:.|||..|.
  Rat   645 QAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMAVWEHTFT 709

  Fly   704 PREYLCQNLEHRFSRDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNC 768
            |||||..:||.||::.:|||.|:||.|.|||||||||.||||||.|||::||||.|||||||||.
  Rat   710 PREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNV 774

  Fly   769 LLQQTQALDSHGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDL 833
            ||||||.||||||.||.:||..||.|.|||:||.|:|.:....||||.:..|..:.||.:|:||:
  Rat   775 LLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDI 839

  Fly   834 NELRALAELVGPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ 898
            :|:|:|:||:||||:|.|:|:|||||::||.|||.||..|.:||..:|||||||:.|...||||.
  Rat   840 SEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLS 904

  Fly   899 DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVAS---EMAS 960
            .||.||:||||||||:.||:|..|||.|||...||||:||::||::|:|....::||.   |::|
  Rat   905 SVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSS 969

  Fly   961 AAGLLCKVDPTLATTLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNN 1023
            ||||.|::||.|...|.|:|.|  ..|.|:..|||||||||||:|.||.|..|.|...|:||.||
  Rat   970 AAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNN 1034

  Fly  1024 THCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIV 1088
            .||:|.|||.|..||||| .:..:|||:||||||||||||::|||:||..||||||:|||||.||
  Rat  1035 IHCLAKAINQIAAALFTI-HKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIV 1098

  Fly  1089 KQSPFLTMDLLESCFPYVLIRNAYHGVYKQ 1118
            ::|||||||||||||||||:|||||.||||
  Rat  1099 QESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:286778	668/1121 (60%)
Nckap1	XP_038961669.1	Nckap1	13..1128	CDD:401614	668/1121 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345954
Domainoid	1	1.000	1286	1.000	Domainoid score	I8
eggNOG	1	0.900	-	-		E1_KOG1917
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8384
Inparanoid	1	1.050	1353	1.000	Inparanoid score	I126
OMA	1	1.010	-	-		QHG54606
OrthoDB	1	1.010	-	-		D138196at2759
OrthoFinder	1	1.000	-	-		FOG0003146
OrthoInspector	1	1.000	-	-		otm45635
orthoMCL	1	0.900	-	-		OOG6_103432
Panther	1	1.100	-	-	LDO	PTHR12093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810