Protein Alignment Hem and nckap1l

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001107884.1
• Gene: nckap1l / 556951
• ZFINID: ZDB-GENE-080204-117
• Length: 1123
• Species: Danio rerio
• Alignment Length: 1121
• Identity: 512/1121 - (45%)
• Similarity: 761/1121 - (67%)
• Gaps: 20/1121 - (1%)

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||:||.|||.|:|.||.:|||...|.|.:|.:.::||:||:||:|.::|||||.:|
Zfish     4 QLKLAEKLLILRDRGQGVLVRINHIKKVFSDPKRRPSYFTDKSMESAIKYINRKFPNIDFRGGSQ 68

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |::|...|..:::.|..||.:|:|:::|:|:|.|||.|:||||...:|.:||:|||.|||||||
Zfish    69 QLSSIQKQKTAVLECLHSYYESFIDVMEFRDHVYELLNTIDACQCFFNIIVNFDLTKNYLDLVVT 133

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|::.:|||:||:||::|:||:||||.|..:|..:||||||.|:||.|.|||:|||.||.:.:|
Zfish   134 YASVIYMLSRIEDKKAIVGMYNSAYELSNGNSDPSYPRLGQMFLEYEHPWKKLSEEFGPHTKAVT 198

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .|:.||..:|..|||.||:||..|.|||:.:||.:|.....||::|||:|:|.|:|||:.|.||.
Zfish   199 EAVLSLHLVYPRRNLTADQWRSAQLLSLLASPAAMLSPACCDTVACEYLSMEVMERWILIGFLLC 263

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|........:|..||.:...:::.|||:|.||:..:..||.:|||||||.::||.....:..
Zfish   264 HASLNTNANSQSLWKMALRNGLYISIIRDELLNIHKLSEEFFDSLKGYSKRIADIKECKEHVLAN 328

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            ...:.||:|.:||.|||||..::.|:|.|||||.:|:|:.|..:|||:|||:||.:|.|    |.
Zfish   329 CGALRREKRSYLRNALKELTKVLEDEPALLGPKVLFVFMALSFSRDEVLWLVRHMENIP----KT 389

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||..|.|:.||||:||:||||:.::..|:|||::|||:.:||..||..:|.:.:|||:||::
Zfish   390 KTPEDYADPQMAELLFYMEKLRALLLRHRYVVQRYHLQYLAQYDALVLNDTIQGMLVCPEEESVL 454

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:|.:||::|.::..|.|..:|.||||.|||.|.|||||.|.:.::.|||::::...||:|
Zfish   455 MSSFVSTLSALSLKHLDAGEQFDLKPLRLDWLRLQVYTSVGKAPLALKDYPELAKIMNVSQFHSR 519

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::|:|.||:|||:.||:.::|:..|....|.....||::.|||:||||....|.:||||..
Zfish   520 MLDSVEELLWETTDLSVLCFHARVFEKLFSQSSEDVCVQRYLMGFPLVCSHFSQSLHPLCPEETE 584

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARKKK-DKSKSKH 653
            .:.::||.:...||||::::...::..||.||..:.:.|||||.|:.:|  :||.|| .|.:.|.
Zfish   585 DLEKQSLKLCVSFLEEISRQTSAVVLEICAEQWNLHEKLLPKHSAQTIS--TARNKKLKKVQPKK 647

  Fly   654 FDDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFS 717
            .|..| |||.||.||.|..:|.:||:|..|||||.:.:.|...:|......|.|:|...||.|.:
Zfish   648 GDAPREKPGAESLRKDRAFVTNLDKMHQTLTELCSSFSICTDFSVCRHVIVPAEFLLTQLEIRLN 712

  Fly   718 RDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEK 782
            :..|.|..:||.|.||::||:|.:.::||::.:.|:.:|::||::|:..:.||||||.|||:|.:
Zfish   713 KVFVQMAGYNQSTHEISRPSDLASGMQAYVSAIHTLSSYINIDVSRLVKSVLLQQTQPLDSYGAQ 777

  Fly   783 TIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYG 847
            ||..||..||.|.|||:.|:..||.....:.|:..:.|....|:.:|:||:..||:||||:||||
Zfish   778 TITTLYTNWYLEGLLRQASSALIVHCPTTQCFINQNTENEQNFHAEEYSDIGGLRSLAELIGPYG 842

  Fly   848 IKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGV 912
            :|.|:|.|||||.:||.|||.|||.|.:||:.:|.:::.||.|.|..|:|...:.||:|||||||
Zfish   843 MKFLSENLMWHIISQVGELKKLVSDNMDVLVQMRANYEDPEAMSELQKKLAGCENVLKRMTIIGV 907

  Fly   913 IICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRV---ASEMASAAGLLCKVDPTLAT 974
            |:.||::|.|||.:::|:..|||:..::..::.:.....|:|   ..||||||||.|::||.|.:
Zfish   908 ILSFRSMVQEALEEIMDRHCPFLMKPIRCLKDFVCPEIDIKVTLGVYEMASAAGLPCEIDPALVS 972

  Fly   975 TL---KSKKPEFDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFG 1036
            .|   ::..|..:| |:..:|||:|::|||:|.|..:.||||.....||.||.||:|.|:|::..
Zfish   973 ALANMQTDNPSMEE-EYKISCLLLVYIAVSLPSLCLDPNSFYSREHGGHQNNIHCLATAVNHVAA 1036

  Fly  1037 ALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLES 1101
            |:||: .:.:::.:|:|||.:|||.||:|||..|....:||:|:|:||..||:|||||:.|:||.
Zfish  1037 AMFTV-QRKNIQTQMQEFLKVASSVLLQLGQNVDNREIKNRDSVYILLHMIVEQSPFLSQDMLEM 1100

  Fly  1102 CFPYVLIRNAYHGVYK 1117
            ||||||:||||..|:|
Zfish  1101 CFPYVLLRNAYREVHK 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	510/1118 (46%)
nckap1l	NP_001107884.1	Nckap1	7..1116	CDD:462866	509/1116 (46%)