DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hem and Nckap1l

DIOPT Version :9

Sequence 1:	NP_524214.1	Gene:	Hem / 40462	FlyBaseID:	FBgn0011771	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_008763975.1	Gene:	Nckap1l / 315348	RGDID:	1312032	Length:	1134	Species:	Rattus norvegicus

Alignment Length:	1118	Identity:	536/1118 - (47%)
Similarity:	768/1118 - (68%)	Gaps:	16/1118 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKG--- 70
            |.|:||||.||||||.|:|.|:|||||.|.|.||||.||.|||:||.:|:|.|:||||||:.
  Rat     8 QHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPPFLLEKSMESCLKYINKKFPNIDVRNSTQ 72

  Fly    71 -LNAIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
             |..:...|||||:.|:.||.:|||:::|:|:|.|||.|:||||.|.||.|||:.|:.||||:||
  Rat    73 HLGPVHREKAEIIRFLTNYYQSFVDVMEFRDHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVT 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            |.|::::|||:|||:.::|:||.|:|:.:...|..|||||||:|:|:.|||||.|||.||.:.::
  Rat   138 YTSVILLLSRIEDRRLLIGMYNCAHEMLHGHGDPSFPRLGQMVLEYDHPLKKLTEEFGPHTKAVS 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            .||.||..::..||..|::||..|.|||:.:|..::....:|||:|||:|:|.|:||||.|.||.
  Rat   203 GALLSLYFLFVRRNQGAEQWRSAQLLSLISSPPAMINPANSDTMACEYLSVEVMERWIIIGFLLC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|....:..|:|...||.|..:.|.|::|||:|:..:..|..:||||||:.::||:...|:..
  Rat   268 HGCLNSNSQCQKLWKLCLEGSLYITLIREDVLQVHKVTEDLFSSLKGYSKRVADIKESKEHAITN 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            :...|.:||:|||||:|||..::.|:||||||||:|.|:.|...|||:.||:||.:|    ..|.
  Rat   333 SGQFHCQRRQFLRTAVKELETVLNDEPGLLGPKALFAFMALSFIRDEVTWLVRHTEN----VTKT 393

  Fly   395 KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESII 459
            |:.||..|..:.||||.:||:|||||::.:|:|:|::|||:.||...|:..:|:|.:|||:||:|
  Rat   394 KTPEDYADSSIAELLFLLEEIRALVRRHIKVIQQYHLQYLARFDVLVLSDIIQNLTVCPEEESVI 458

  Fly   460 FSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHTR 524
            .||..:|.::|.:|||::.|.|.|...||||||||.|.||.||.|.:.|:.:||::::.::||::
  Rat   459 MSSFVSTLSSLNLKQVDNEEKFDFSGLRLDWFRLQAYTSVAKAPLHLHENPDLAKVMNLIIFHSQ 523

  Fly   525 VVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEERH 589
            ::|:::::||||||||.|||:.:.|:..|...||.|...||.|||||||:||.:|.|||||||..
  Rat   524 MLDSVEKMLVETSDLSTFCFHLRTFEKMFATTLEEPTMLRYTIAFPLICAHFVHCIHEMCPEEYP 588

  Fly   590 HIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARK--KKDKSKSK 652
            |::...|...|.||||:||:..|.:..||.||..:.:.|||||||..:|....||  |:.::..|
  Rat   589 HLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLNEQLLPKHCATTISKAKNRKSMKQRQAPRK 653

  Fly   653 HFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEHRFS 717
            ...:..|||.||:||.|..:|.|||||:.||||..|:|:..:.:|:|....|.|||..:||.|.:
  Rat   654 GEPERDKPGAESHRKNRSLVTNMDKLHLNLTELALAMNHVHSFSVFEHTIFPSEYLSSHLESRLN 718

  Fly   718 RDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDSHGEK 782
            |.:|.:..:|..|.||.:||||||.|:||.:.:|::..::..|.:|:..|.||||||.|||.||:
  Rat   719 RAIVSLAGYNATTQEILRPSELLAGVKAYTSFIQSLAQFLGTDASRIVRNALLQQTQPLDSCGEQ 783

  Fly   783 TIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELVGPYG 847
            |:..||..||.|.|||:.|:|.||.|...:||:.:..:|...|:.:||||::|:|||||::||||
  Rat   784 TVTTLYTNWYLESLLRQASSGTIVLSPAMQAFISLPRDGEQNFSAEEFSDISEMRALAEILGPYG 848

  Fly   848 IKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQDVDRVLQRMTIIGV 912
            :|.|:|.||||:.:|:.|||.||..|.::|:.:|::|.|||:|.....:|...:.||:|||||||
  Rat   849 MKFLSENLMWHVTSQIVELKKLVVENMDILVQIRSNFTKPELMASLLPQLTGAENVLKRMTIIGV 913

  Fly   913 IICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRV---ASEMASAAGLLCKVDPTLAT 974
            |:.||.:..|.|.:|.....|||:..::..:|.:.....|:|   ..|:|.|||:.|.:||.|..
  Rat   914 ILSFRAMAQEGLQEVFSAHCPFLMGPIECLKEFVTPDTDIKVTLSVFELACAAGVSCDIDPALVA 978

  Fly   975 TLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNTHCMAAAINNIFGA 1037
            .:.:.|.:  ..|.|:..||||::|:|||:|.||.:.:||:....||::||.||:..||..:..|
  Rat   979 AIANLKADNSSPEEEYKVACLLLIFLAVSLPLLATDPSSFFSIEKDGYNNNIHCLTKAIIQVSAA 1043

  Fly  1038 LFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIVKQSPFLTMDLLESC 1102
            |||:..: ::|..:||||.:||.|||:||||:||..|||||||.||:..:|::|||||:|:||||
  Rat  1044 LFTLYNK-NIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLLMRLVVEESPFLTLDMLESC 1107

  Fly  1103 FPYVLIRNAYHGV 1115
            |||||:||||..|
  Rat  1108 FPYVLLRNAYREV 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:286778	534/1115 (48%)
Nckap1l	XP_008763975.1	Nckap1	11..1123	CDD:286778	534/1115 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1917
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54606
OrthoDB	1	1.010	-	-		D138196at2759
OrthoFinder	1	1.000	-	-		FOG0003146
OrthoInspector	1	1.000	-	-		otm45635
orthoMCL	1	0.900	-	-		OOG6_103432
Panther	1	1.100	-	-	O	PTHR12093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2542
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.760