Protein Alignment Hem and gex-3

DIOPT Version :10

• Sequence 1: NP_524214.1
• Gene: Hem / 40462
• FlyBaseID: FBgn0011771
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_502368.1
• Gene: gex-3 / 178191
• WormBaseID: WBGene00001580
• Length: 1141
• Species: Caenorhabditis elegans
• Alignment Length: 1141
• Identity: 479/1141 - (41%)
• Similarity: 724/1141 - (63%)
• Gaps: 39/1141 - (3%)

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKGLNA 73
            |.||||||:|||||..|::||||||||:.||:|.||.|||:|.:|.:||.||::||.:|.:..::
 Worm     8 QVKIAEKLVILNDRAAGMMTRIYNIKKSSGDSKVKPQFLSDKKMEGAIKHIVRKFPVVDCRSNSS 72

  Fly    74 ----IVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
                :.....||.|||||||:||.|:||.||::.::||||::||..||:|||::||..||:|||.
 Worm    73 TFEYVQEKSTEITKSLSLYYYTFADILDLKDHIMQVLTTMESCQCQLDVTLNYDLTTSYLNLVVH 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            .|::||:|||:|||||||||:||||:||:.|::..||||||||||||.|||||.|:..|..||:.
 Worm   138 LVTMMILLSRIEDRKAVLGLFNAAYDLQHGQSEASFPRLGQMILDYENPLKKLHEDLGPLNRLIY 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            |||.|:|..|..||..||.||.....||...||.:|.|.:|:|::|||:||:.:||||:|...:.
 Worm   203 SALSSVTHTYQRRNKTADSWRTSNVFSLTAAPAQILYAAQTETIACEYLSLDVIDRWIVFCGTVC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|.....:..:|..||:.:..:.:||||...:||.|||..:..|..|||:.:||:|:|.|...
 Worm   268 HSTLLNDDNIRHMWQLALQMNLCLRVFRDETFIVHQEIQAFLESSKEKSKRLQDVKDAFNHASVT 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            |..:|.:||:|||::|:||:|::.|||||||||.:::::.|...|||::|||||....|.:..||
 Worm   333 AVAVHADRRRFLRSSLRELSLLLRDQPGLLGPKILYVWMALGAGRDEVIWLLRHQVEVPAISKKG 397

  Fly   395 -KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESI 458
             :..|:|||||||||||:|.|||.||.||..|:||||:||:|.:|:..::..:.......::|::
 Worm   398 SRMVEELVDRQLPELLFYMLELRDLVTKYYAVIQRYYLQYVSSYDSIVVSEEINQANGLTQEEAV 462

  Fly   459 IFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHT 523
            :.:...|....:.    .|.:|   |..||||||.|.:.|..::..:::.|.:||..:::.|||.
 Worm   463 LLTDFANEIGNIN----SDTDL---RALRLDWFRFQAWTSAARSHFQLSRHKKLAIYMNTSVFHL 520

  Fly   524 RVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEER 588
            :::|..||:|.||||||::|||.|:.:..:..||:.|||.||:::|..:.:||.:..|:|||||:
 Worm   521 KMIDLQDEMLRETSDLSLYCFYPKLAEKHWLNCLQLPAQARYVLSFARLAAHFTSALHDMCPEEK 585

  Fly   589 HHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARKKKD----KS 649
            ..|.|::|:..|..:||..|:...|:..:.:.:..:|..:.|...|..:..|..::|..    .:
 Worm   586 AFITEKALAQCNSVIEETCKQLSYILEKVAEHEFGLAYQMTPSAVAVRVVAQVVQQKGSGKAAAA 650

  Fly   650 KSKHFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEH 714
            .:....|....|:||||..|:.||..|||...|.|:..|:.....:.|.:..||||.||.|:||.
 Worm   651 AAAAARDYFIAGEESYRVDRQALTMPDKLQTTLLEISAALGAHRQIYVADHTFAPRTYLAQSLET 715

  Fly   715 RFSRDLVGMVMFNQ-ETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDS 778
            :|...|.||....| ......:|||:|.:::|||.|||.::..:.:||:......||||||.:||
 Worm   716 KFVELLHGMFWEGQPHASNPKRPSEMLLALQAYMTVLQNLDTAISVDISNTMQTTLLQQTQLVDS 780

  Fly   779 HGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELV 843
            ..:.||||||..||.||||||.|:|::|:|.:.:..:. |.:..:.|.|..:||..|||||.:::
 Worm   781 KNKDTIAALYTKWYLEVLLRRASSGHMVWSEHLRTMLS-SGQEQLSFMPDHYSDPQELRALVQII 844

  Fly   844 GPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ---------- 898
            ||||:|.:.|.|:||:|:|:.|:..:|:|.|:.|...|::||..|.||:....|.
 Worm   845 GPYGVKLMTERLIWHVASQIMEMSKIVATYKDALQIARSNFDNAEKMKDVLNLLSVEPKDKKTPN 909

  Fly   899 ---DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVASEMAS 960
               ..|.:|||..|||.|..||:.:|:||..:::.::|||.:|......:|...|:::: .||::
 Worm   910 ATCAADAILQRTIIIGQICLFRDALHDALRHIVESKLPFLQASFDMLYHNLDDVDKVKI-GEMSA 973

  Fly   961 AAGLLCKVDPTLATTLKSKKPEFDEGEH-LTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNT 1024
            |.|:...||.:|...::::.|.....|| :.:|||||.||:.||::..::.|.|:.:|....||:
 Worm   974 AMGVTGPVDMSLVNAVRAQNPNIHPQEHYVNSCLLMVAVAICIPRIGMSDLSSYKPSIQASLNNS 1038

  Fly  1025 HCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDK------EATRNRESIYLL 1083
            ||:..|||.|..|||.:..|:|::.|||||||||||.:||...|.|.      :..|:..::|::
 Worm  1039 HCVPMAINTIGSALFHLHEQNDIQSRMKEFLALASSGILRTIHERDNSRQISDDVLRSHTTLYII 1103

  Fly  1084 LDEIVKQSPFLTMDLLESCFPYVLIRNAYHGVYKQE 1119
            |:::|:::.:|:||:||:||||.|:|.||...|:.:
 Worm  1104 LEQMVRKNRWLSMDVLETCFPYNLVRTAYQQCYEAD 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:462866	477/1135 (42%)
gex-3	NP_502368.1	Nckap1	11..1138	CDD:462866	477/1135 (42%)