DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hem and gex-3

DIOPT Version :9

Sequence 1:	NP_524214.1	Gene:	Hem / 40462	FlyBaseID:	FBgn0011771	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_502368.1	Gene:	gex-3 / 178191	WormBaseID:	WBGene00001580	Length:	1141	Species:	Caenorhabditis elegans

Alignment Length:	1141	Identity:	479/1141 - (41%)
Similarity:	724/1141 - (63%)	Gaps:	39/1141 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QQKIAEKLIILNDRGLGILTRIYNIKKACGDTKSKPGFLSEKSLESSIKFIVKRFPNIDVKGLNA 73
            |.||||||:|||||..|::||||||||:.||:|.||.|||:|.:|.:||.||::||.:|.:..::
Worm     8 QVKIAEKLVILNDRAAGMMTRIYNIKKSSGDSKVKPQFLSDKKMEGAIKHIVRKFPVVDCRSNSS 72

  Fly    74 ----IVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDITLNFELTKYYLDLVVT 134
                :.....||.|||||||:||.|:||.||::.::||||::||..||:|||::||..||:|||.
Worm    73 TFEYVQEKSTEITKSLSLYYYTFADILDLKDHIMQVLTTMESCQCQLDVTLNYDLTTSYLNLVVH 137

  Fly   135 YVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPLKKLAEEFIPHQRLLT 199
            .|::||:|||:|||||||||:||||:||:.|::..||||||||||||.|||||.|:..|..||:.
Worm   138 LVTMMILLSRIEDRKAVLGLFNAAYDLQHGQSEASFPRLGQMILDYENPLKKLHEDLGPLNRLIY 202

  Fly   200 SALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYISLEAMDRWIIFGLLLN 264
            |||.|:|..|..||..||.||.....||...||.:|.|.:|:|::|||:||:.:||||:|...:.
Worm   203 SALSSVTHTYQRRNKTADSWRTSNVFSLTAAPAQILYAAQTETIACEYLSLDVIDRWIVFCGTVC 267

  Fly   265 HQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSKRIGEVKEAYNTAVQK 329
            |..|.....:..:|..||:.:..:.:||||...:||.|||..:..|..|||:.:||:|:|.|...
Worm   268 HSTLLNDDNIRHMWQLALQMNLCLRVFRDETFIVHQEIQAFLESSKEKSKRLQDVKDAFNHASVT 332

  Fly   330 AALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILWLLRHNDNPPLLKNKG 394
            |..:|.:||:|||::|:||:|::.|||||||||.:::::.|...|||::|||||....|.:..||
Worm   333 AVAVHADRRRFLRSSLRELSLLLRDQPGLLGPKILYVWMALGAGRDEVIWLLRHQVEVPAISKKG 397

  Fly   395 -KSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNIRMQSLQMCPEDESI 458
             :..|:|||||||||||:|.|||.||.||..|:||||:||:|.:|:..::..:.......::|::
Worm   398 SRMVEELVDRQLPELLFYMLELRDLVTKYYAVIQRYYLQYVSSYDSIVVSEEINQANGLTQEEAV 462

  Fly   459 IFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEHAELARLLDSMVFHT 523
            :.:...|....:.    .|.:|   |..||||||.|.:.|..::..:::.|.:||..:::.|||.
Worm   463 LLTDFANEIGNIN----SDTDL---RALRLDWFRFQAWTSAARSHFQLSRHKKLAIYMNTSVFHL 520

  Fly   524 RVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICSHFQNCTHEMCPEER 588
            :::|..||:|.||||||::|||.|:.:..:..||:.|||.||:::|..:.:||.:..|:|||||:
Worm   521 KMIDLQDEMLRETSDLSLYCFYPKLAEKHWLNCLQLPAQARYVLSFARLAAHFTSALHDMCPEEK 585

  Fly   589 HHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSVQSARKKKD----KS 649
            ..|.|::|:..|..:||..|:...|:..:.:.:..:|..:.|...|..:..|..::|..    .:
Worm   586 AFITEKALAQCNSVIEETCKQLSYILEKVAEHEFGLAYQMTPSAVAVRVVAQVVQQKGSGKAAAA 650

  Fly   650 KSKHFDDIRKPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFAPREYLCQNLEH 714
            .:....|....|:||||..|:.||..|||...|.|:..|:.....:.|.:..||||.||.|:||.
Worm   651 AAAAARDYFIAGEESYRVDRQALTMPDKLQTTLLEISAALGAHRQIYVADHTFAPRTYLAQSLET 715

  Fly   715 RFSRDLVGMVMFNQ-ETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQALDS 778
            :|...|.||....| ......:|||:|.:::|||.|||.::..:.:||:......||||||.:||
Worm   716 KFVELLHGMFWEGQPHASNPKRPSEMLLALQAYMTVLQNLDTAISVDISNTMQTTLLQQTQLVDS 780

  Fly   779 HGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDLNELRALAELV 843
            ..:.||||||..||.||||||.|:|::|:|.:.:..:. |.:..:.|.|..:||..|||||.:::
Worm   781 KNKDTIAALYTKWYLEVLLRRASSGHMVWSEHLRTMLS-SGQEQLSFMPDHYSDPQELRALVQII 844

  Fly   844 GPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ---------- 898
            ||||:|.:.|.|:||:|:|:.|:..:|:|.|:.|...|::||..|.||:....|.
Worm   845 GPYGVKLMTERLIWHVASQIMEMSKIVATYKDALQIARSNFDNAEKMKDVLNLLSVEPKDKKTPN 909

  Fly   899 ---DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVASEMAS 960
               ..|.:|||..|||.|..||:.:|:||..:::.::|||.:|......:|...|:::: .||::
Worm   910 ATCAADAILQRTIIIGQICLFRDALHDALRHIVESKLPFLQASFDMLYHNLDDVDKVKI-GEMSA 973

  Fly   961 AAGLLCKVDPTLATTLKSKKPEFDEGEH-LTACLLMVFVAVSIPKLARNENSFYRATIDGHSNNT 1024
            |.|:...||.:|...::::.|.....|| :.:|||||.||:.||::..::.|.|:.:|....||:
Worm   974 AMGVTGPVDMSLVNAVRAQNPNIHPQEHYVNSCLLMVAVAICIPRIGMSDLSSYKPSIQASLNNS 1038

  Fly  1025 HCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDK------EATRNRESIYLL 1083
            ||:..|||.|..|||.:..|:|::.|||||||||||.:||...|.|.      :..|:..::|::
Worm  1039 HCVPMAINTIGSALFHLHEQNDIQSRMKEFLALASSGILRTIHERDNSRQISDDVLRSHTTLYII 1103

  Fly  1084 LDEIVKQSPFLTMDLLESCFPYVLIRNAYHGVYKQE 1119
            |:::|:::.:|:||:||:||||.|:|.||...|:.:
Worm  1104 LEQMVRKNRWLSMDVLETCFPYNLVRTAYQQCYEAD 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:286778	477/1135 (42%)
gex-3	NP_502368.1	Nckap1	11..1138	CDD:286778	477/1135 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162501
Domainoid	1	1.000	885	1.000	Domainoid score	I13
eggNOG	1	0.900	-	-		E1_KOG1917
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8384
Inparanoid	1	1.050	896	1.000	Inparanoid score	I194
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54606
OrthoDB	1	1.010	-	-		D138196at2759
OrthoFinder	1	1.000	-	-		FOG0003146
OrthoInspector	1	1.000	-	-		oto18702
orthoMCL	1	0.900	-	-		OOG6_103432
Panther	1	1.100	-	-	LDO	PTHR12093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2541
SonicParanoid	1	1.000	-	-		X2542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800