DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hem and NCKAP1

DIOPT Version :9

Sequence 1:	NP_524214.1	Gene:	Hem / 40462	FlyBaseID:	FBgn0011771	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_995314.1	Gene:	NCKAP1 / 10787	HGNCID:	7666	Length:	1134	Species:	Homo sapiens

Alignment Length:	1135	Identity:	675/1135 - (59%)
Similarity:	867/1135 - (76%)	Gaps:	24/1135 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARPIF-PNQQKIAEKLIILNDRGLGILTRIYNIK------KACGDTKSKPGFLSEKSLESSIKF 58
            |:|.:. |:|||:||||.||||||:|:|||:||||      |||||.|:||.:|.:|:|||::||
Human     1 MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKQGQVWKACGDPKAKPSYLIDKNLESAVKF 65

  Fly    59 IVKRFPNIDVKGLN----AIVNIKAEIIKSLSLYYHTFVDLLDFKDNVCELLTTMDACQIHLDIT 119
            ||::||.::.:..|    .:...|:||:|:|:|||.||||:::|||:|||||.|:|.||:..|||
Human    66 IVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDIT 130

  Fly   120 LNFELTKYYLDLVVTYVSLMIVLSRVEDRKAVLGLYNAAYELQNNQADTGFPRLGQMILDYEVPL 184
            :||:|||.||||::||.:|||:|||:|:|||::||||.|:|:.:..:|..:|||||||:|||.||
Human   131 VNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPL 195

  Fly   185 KKLAEEFIPHQRLLTSALRSLTSIYALRNLPADKWREMQKLSLVGNPAILLKAVRTDTMSCEYIS 249
            ||:.|||:||.:.|:.||.||..:|..|||.||:||..|.|||:..|:.:|...::|||.|||:|
Human   196 KKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLS 260

  Fly   250 LEAMDRWIIFGLLLNHQMLGQYPEVNKIWLSALESSWVVALFRDEVLQIHQYIQATFDGIKGYSK 314
            |:||::|||||.:|.|.:|........:|..||:||..::||||||..||:..:..|..|:||:|
Human   261 LDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNK 325

  Fly   315 RIGEVKEAYNTAVQKAALMHRERRKFLRTALKELALIMTDQPGLLGPKAIFIFIGLCLARDEILW 379
            ||.:::|....||..|..||||||||||:||||||.:::||||||||||:|:|:.|..|||||:|
Human   326 RINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIW 390

  Fly   380 LLRHNDNPPLLKNKGKSNEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDATDLNI 444
            ||||.||.|     .||.:|.:|:.:.||:|:||||||.||||..|||||||||||||||..||.
Human   391 LLRHADNMP-----KKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNE 450

  Fly   445 RMQSLQMCPEDESIIFSSLYNTAAALTVKQVEDNELFYFRPFRLDWFRLQTYMSVGKAALRIAEH 509
            .:|:|.:||||||||.||..||..:|:||||||.|:|.||..||||||||.|.||.||:|.:|:|
Human   451 LVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADH 515

  Fly   510 AELARLLDSMVFHTRVVDNLDEILVETSDLSIFCFYNKMFDDQFHMCLEFPAQNRYIIAFPLICS 574
            .||.:::::::|||::||:|.|:|||||||||||||::.|:..|..|||.|:|:||.|||||:|:
Human   516 RELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCT 580

  Fly   575 HFQNCTHEMCPEERHHIRERSLSVVNIFLEEMAKEAKNIITTICDEQCTMADALLPKHCAKILSV 639
            ||.:||||:||||||||.:||||:.|:||:||||:|:|:||.||.||||::|.||||||||.:|
Human   581 HFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTIS- 644

  Fly   640 QSARKKKDKSKSKHFDDIR-KPGDESYRKTREDLTTMDKLHMALTELCFAINYCPTVNVWEFAFA 703
            |:..||..|...|..:..| |||.||.||.|..:|.:||||.||:||||:|||.|.:.|||..|.
Human   645 QAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFT 709

  Fly   704 PREYLCQNLEHRFSRDLVGMVMFNQETMEIAKPSELLASVRAYMNVLQTVENYVHIDITRVFNNC 768
            |||||..:||.||::.:|||.|:||.|.|||||||||.||||||.|||::||||.|||||||||.
Human   710 PREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNV 774

  Fly   769 LLQQTQALDSHGEKTIAALYNTWYSEVLLRRVSAGNIVFSINQKAFVPISPEGWVPFNPQEFSDL 833
            ||||||.||||||.||.:||..||.|.|||:||.|:|.:....||||.:..|..:.||.:|:||:
Human   775 LLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDI 839

  Fly   834 NELRALAELVGPYGIKTLNETLMWHIANQVQELKSLVSTNKEVLITLRTSFDKPEVMKEQFKRLQ 898
            :|:|:|:||:||||:|.|:|:|||||::||.|||.||..|.:||..:|||||||:.|...||||.
Human   840 SEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLS 904

  Fly   899 DVDRVLQRMTIIGVIICFRNLVHEALVDVLDKRIPFLLSSVKDFQEHLPGGDQIRVAS---EMAS 960
            .||.||:||||||||:.||:|..|||.|||...||||:||::||::|:|....::||.   |::|
Human   905 SVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSS 969

  Fly   961 AAGLLCKVDPTLATTLKSKKPE--FDEGEHLTACLLMVFVAVSIPKLARNENSFYRATIDGHSNN 1023
            ||||.|::||.|...|.|:|.|  ..|.|:..|||||||||||:|.||.|..|.|...|:||.||
Human   970 AAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNN 1034

  Fly  1024 THCMAAAINNIFGALFTICGQSDMEDRMKEFLALASSSLLRLGQESDKEATRNRESIYLLLDEIV 1088
            .||:|.|||.|..||||| .:..:|||:||||||||||||::|||:||..||||||:|||||.||
Human  1035 IHCLAKAINQIAAALFTI-HKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIV 1098

  Fly  1089 KQSPFLTMDLLESCFPYVLIRNAYHGVYKQ 1118
            ::|||||||||||||||||:|||||.||||
Human  1099 QESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hem	NP_524214.1	Nckap1	12..1118	CDD:286778	667/1121 (60%)
NCKAP1	NP_995314.1	Nckap1	13..1128	CDD:401614	667/1121 (60%)
NCKAP1	NP_995314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..671		9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152439
Domainoid	1	1.000	1293	1.000	Domainoid score	I9
eggNOG	1	0.900	-	-		E1_KOG1917
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8384
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54606
OrthoDB	1	1.010	-	-		D138196at2759
OrthoFinder	1	1.000	-	-		FOG0003146
OrthoInspector	1	1.000	-	-		otm41515
orthoMCL	1	0.900	-	-		OOG6_103432
Panther	1	1.100	-	-	LDO	PTHR12093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2541
SonicParanoid	1	1.000	-	-		X2542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800