DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srpk79D and Srpk1

DIOPT Version :9

Sequence 1:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_001020897.1	Gene:	Srpk1 / 361811	RGDID:	1308272	Length:	655	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	283/747 - (37%)
Similarity:	387/747 - (51%)	Gaps:	150/747 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFS 359
            ::.||:...::...|:..:..|...|:||||.:.||:||||.|.|||:|:.|:.|:|||||||||
  Rat    28 TQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFS 92

  Fly   360 TVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVN 424
            ||||..|::.:|:||:||||||.||.|||.||||||:::|::||.|...|.:|:|::.|.:.|||
  Rat    93 TVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVN 157

  Fly   425 GMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV 489
            |.|.|:|||.||..|.|.|:|:|||||.:..|:.||:|||:||||||:||.|||||||||||||
  Rat   158 GTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL- 221

  Fly   490 IDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATN 554
                 ::|:|                  ||..:..:.....:.....|:||       :.|||..
  Rat   222 -----SVNEQ------------------YIRRLAAEATEWQRSGAPPPSGS-------AVSTAPQ 256

  Fly   555 SNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRT 619
            ...:..::......|.|:           ....:.|..|....:.:.|...| .|....|.:..:
  Rat   257 PKPADKMSKNKKKKLKKK-----------QKRQAELLEKRMQEIEEMEKESG-PGQKRPNKQEES 309

  Fly   620 ----EKKITAKSSGDCDED--AESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPSEGPIP 678
                |:.:|........::  .||.::|:..||..                      ...||..|
  Rat   310 ESPVERPLTENPPNKMTQEKLEESSSIGQDQTLTE----------------------HGGEGGAP 352

  Fly   679 E----------QPTPNSTNSSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTP 733
            |          ..|.||.|      .|..:.:...|:|   .|...|...|..|       .|:|
  Rat   353 EINCNGVIGIVNYTANSNN------ETLRLKEDLHNAN---DCDGRTLKQEPSF-------LSSP 401

  Fly   734 SAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTS 798
            :...|.:|.:          .:||||.:::      |.| ..|..|.|
  Rat   402 NGDSSPSPET----------DSCTPSGSEV------PET-MACQASVE----------------- 432

  Fly   799 NAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSN-------------V 850
               .|.|.|....|....::..|.   ||.::.:...|.....:......|             :
  Rat   433 ---RSLTLTQQDITHLQERIRAHT---PSGDEQEREHNGALDSKGKFSAGNFLINPLEPKNAEKL 491

  Fly   851 RVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAG 915
            :||||||||||:.:.|||||||||||||:|||:|:.||..||||||||:|||||||||||:||:|
  Rat   492 KVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSG 556

  Fly   916 ESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPV 980
            |.|:|||||:|.|:||||.:|:.:|..||:..::||..|.|::|||||||.|:.||||||:|...
  Rat   557 EDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQE 621

  Fly   981 EAKKFSDFLLPMLEYNPVIRASAAECLQHPWL 1012
            ||..|:||||||||..|..||:|||||:||||
  Rat   622 EAAGFTDFLLPMLELMPEKRATAAECLRHPWL 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	98/167 (59%)
		S_TKc	347..>492	CDD:214567	90/144 (63%)
		STKc_SRPK	<844..1012	CDD:271038	109/180 (61%)
Srpk1	NP_001020897.1	PKc_like	70..653	CDD:304357	266/703 (38%)
Srpk1	NP_001020897.1	S_TKc	80..>224	CDD:214567	90/149 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45924
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820