DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srpk79D and Srpk1

DIOPT Version :9

Sequence 1:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_058075.2	Gene:	Srpk1 / 20815	MGIID:	106908	Length:	648	Species:	Mus musculus

Alignment Length:	729	Identity:	281/729 - (38%)
Similarity:	393/729 - (53%)	Gaps:	121/729 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFS 359
            ::.||:...::...|:..:..|...|:||||.:.||:||||.|.|||:|:.|:.|:|||||||||
Mouse    28 TQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFS 92

  Fly   360 TVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVN 424
            ||||..|::.:|:||:||||||.||.|||.||||||:::|::||.|...|.:|:|::.|.:.|||
Mouse    93 TVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVN 157

  Fly   425 GMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLV 489
            |.|.|:|||.||..|.|.|:|:|||||.:..|:.||:|||:||||||:||.|||||||||||||
Mouse   158 GTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL- 221

  Fly   490 IDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATN 554
                 ::|:|                  ||..:..:.....:.....|:||       :.|||..
Mouse   222 -----SVNEQ------------------YIRRLAAEATEWQRSGAPPPSGS-------AVSTAPQ 256

  Fly   555 SNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRT 619
            ...:..::......|.|:           ....:.|..|....:.:.|...| .|....|.:..:
Mouse   257 PKPADKMSKNKKKKLKKK-----------QKRQAELLEKRMQEIEEMEKESG-PGQKRPNKQEES 309

  Fly   620 E----KKITAKSSGDCDED--AESDTLGEQSTLASTMDSPTDLDPE---PELDSKPNTVPEPSEG 675
            |    :.:|........::  .||:::|:..||       |:...|   ||::         ..|
Mouse   310 ESPVDRPLTENPPNKMTQEKLEESNSIGQDQTL-------TERGGEGGAPEIN---------CNG 358

  Fly   676 PIPEQPTPNSTNSSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSAT 740
            .|.....|.::|:....|.     :...|:|   .|...|...|..|.|::...:|......|.|
Mouse   359 VIGVVNYPENSNNETLRHK-----EDLHNAN---DCDVHTLKQEPSFLNSSNGDSSPSQDTDSCT 415

  Fly   741 PSSAPALA--SATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISS 803
            |:::..:.  |:...|......||:..|..|...|           ||.:       ..:.|:.|
Mouse   416 PTASETMVCQSSAEQSLTRQDITQLEESIRADTPS-----------GDEQ-------EPNGALDS 462

  Fly   804 ATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFT 868
            ....:|.        |...|.:..:|..:                 ::||||||||||:.:.|||
Mouse   463 KGKFSAG--------NFLINPLEPKNAEK-----------------LQVKIADLGNACWVHKHFT 502

  Fly   869 EDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLG 933
            ||||||||||:|||:|:.||..||||||||:|||||||||||:||:||.|:|||||:|.|:||||
Mouse   503 EDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLG 567

  Fly   934 SIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPV 998
            .:|:.:|..||:..::||..|.|::|||||||.|:.||||||:|...||..|:||||||||..|.
Mouse   568 KVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPE 632

  Fly   999 IRASAAECLQHPWL 1012
            .||:|||||:||||
Mouse   633 KRATAAECLRHPWL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	98/167 (59%)
		S_TKc	347..>492	CDD:214567	90/144 (63%)
		STKc_SRPK	<844..1012	CDD:271038	108/167 (65%)
Srpk1	NP_058075.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		6/28 (21%)
		PKc_like	70..646	CDD:304357	264/685 (39%)
		S_TKc	80..>224	CDD:214567	90/149 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..354		24/141 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..464		17/86 (20%)
		PKc_like	<469..>545	CDD:304357	50/100 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.680