Protein Alignment Ddx1 and Ddx1

DIOPT Version :10

• Sequence 1: NP_524212.2
• Gene: Ddx1 / 40457
• FlyBaseID: FBgn0015075
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_445866.1
• Gene: Ddx1 / 84474
• RGDID: 619903
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 731
• Identity: 436/731 - (59%)
• Similarity: 558/731 - (76%)
• Gaps: 13/731 - (1%)

  Fly     1 MTAFEEFGVLPELGMATDELDWTLPTDVQAEAIPLILGGGDVLMAAETGSGKTGAFCLPILQIVW 65
            |.||.|.||:||:..|.:|:||.||||:|||:||||||||||||||||||||||||.:|::|||:
  Rat     1 MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVY 65

  Fly    66 ETLRDLEEGKAGKGGAIGGA--VTPWTMSFFDRGNALAVTPDGLRCQSREFKEWHGCRATTGVRG 128
            |||:|.:|||.||.....||  :..|.|:.:|||:|.|:..|||.|||||.|||||||||.|:.
  Rat    66 ETLKDQQEGKKGKATIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATRGLL- 129

  Fly   129 KGKFYFEATVTDEGLCRVGWSTQQANLDLGTCRMGFGFGGTGKKSNNRQFDDYGEAFGKADVIGC 193
            :||.|:|.:..|:|||||||||.||:|||||.:.|||||||||||:|:|||:|||.|...|.|||
  Rat   130 RGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGC 194

  Fly   194 LLDLKNQEVSFTKNGQNLGVAFRLPDNLAKETFYPAVVLKNAEMQFNFGKTDFKYAPGNGFVGAC 258
            .||:....|.|:|||::||:||.:|.::..:..:||.||||||::||||:.:||:.|.:|||...
  Rat   195 YLDIDKGHVKFSKNGKDLGLAFEIPAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALS 259

  Fly   259 QAGPEHSKANPITGPAAGAPSAKPAPNAPQAIIMEPSRELAEQTYNQIEKFKYHLSNPEVRSLLL 323
            :|...:...:..||.|. ....|..||||:|:|:||||||||||.|.:::||.::.||::|.||:
  Rat   260 KAPDSYVVKSQHTGNAQ-VSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLI 323

  Fly   324 IGGVRLEEQKAQLMQGTHIVVGTPGRLEEMINSGLVLLTHCRFFVLDEADALLKQGYTELIDRLH 388
            ||||...:|.:.|..|..|||||||||::::::|.:.|:..||.||||||.||.|||::.|:|:|
  Rat   324 IGGVAARDQLSVLDNGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMH 388

  Fly   389 KQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMHFPTWVDLKGEDAVPETVHHVVCLVDPQMD 453
            .|||:|||||:|||::|||||||:|:|||::|::|||||||||||||:||:||||||..|:|:.|
  Rat   389 NQIPQITSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTD 453

  Fly   454 TTWQSL-RQPIGTDGVHDRDNVHPGNHSKETLSQAVKLLKGEYCVHAIDKHNMDRAIIFCRTKQD 517
            ..|:.| :..|.||.||.:||..||.:|.|..|:|:|:|||||.|.||.:|.||:||||||||.|
  Rat   454 RLWERLGKNHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKID 518

  Fly   518 CDNLERFLRQRG------GKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTDVAARGLDITG 576
            |||||::..|:|      |..:|||||||||||.|||:|||.||:..|:|||||||||||:||.|
  Rat   519 CDNLEQYFMQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHG 583

  Fly   577 LPFMINVTLPDDKTNYVHRIGRVGRAERMGLAISLVATVPEKVWYHGEWCKSRGRSCNNTNLTEV 641
            :|::|||||||:|.||||||||||||||||||||||||..||||||  .|.:||:.|.||.|.|.
  Rat   584 VPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYH--VCSNRGKGCYNTRLKED 646

  Fly   642 RGCCIWYNEPNLLAEVEDHLNITIQQVDKTMDVPVNDFDGKVVYGQKNLRTGSGYEDHVEQLVPT 706
            .||.|||||..||:|:|:|||.||.||:..:.|||::|||||.||||....|..|:.||:.|.||
  Rat   647 GGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGNYKGHVDILAPT 711

  Fly   707 VRKLTELELQSQSLFL 722
            |::|..||.::|:.||
  Rat   712 VQELAALEKEAQTSFL 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddx1	NP_524212.2	DEAD-like_helicase_N	4..>73	CDD:475120	49/68 (72%)
		SPRY_DDX1	91..242	CDD:293933	90/150 (60%)
		SrmB	283..613	CDD:440279	213/336 (63%)
Ddx1	NP_445866.1	Necessary for interaction with RELA. /evidence=ECO:0000250|UniProtKB:Q92499	1..525		308/526 (59%)
		Interaction with dsRNA. /evidence=ECO:0000250|UniProtKB:Q91VR5	1..448		264/448 (59%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250|UniProtKB:Q92499	1..295		169/295 (57%)
		DEAD-like_helicase_N	4..>62	CDD:475120	42/57 (74%)
		SPRY_DDX1	93..245	CDD:293933	91/151 (60%)
		SrmB	284..625	CDD:440279	222/347 (64%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250|UniProtKB:Q92499	525..740		128/204 (63%)