DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddx1 and CG9143

DIOPT Version :9

Sequence 1:	NP_524212.2	Gene:	Ddx1 / 40457	FlyBaseID:	FBgn0015075	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_611467.1	Gene:	CG9143 / 37296	FlyBaseID:	FBgn0034496	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	160/742 - (21%)
Similarity:	258/742 - (34%)	Gaps:	267/742 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTAFEEFGVLPELGMATDELDWTLPTDVQAEAIP-LILGGGDVLMAAETGSGKTGAFCLPILQIV 64
            |:|:...||...:..|..|..:..||.:||..:| .|.|..|:|.|||||||||.||.:|:|..:
  Fly   214 MSAWNGLGVPASILRALGEQGFKTPTQIQALTLPAAIHGKKDILGAAETGSGKTLAFGIPMLAGI 278

  Fly    65 WETLRDLEEGKAGKGGAIGGAVTPWTMSFFDRGNALAVTPDGLRCQSREFKEWHGCRATTGVRGK 129
            .|                                          .:.|..:        :|:|..
  Fly   279 ME------------------------------------------LKQRNIR--------SGIRKA 293

  Fly   130 GKFYFEATVTDEGLCRVGWSTQQANLDLGTCRMGFGFGGTGKKSNNRQFDDYGEAFGKADVIGCL 194
            .|
  Fly   294 PK--------------------------------------------------------------- 295

  Fly   195 LDLKNQEVSFTKNGQNLGVAFRLPDNLAKE---TFYPAVVLKNAEMQFNFGKTDFKYAPGNGFVG 256
              :|.|:                |:..|.|   |..|      .|:....|.:|
  Fly   296 --VKGQQ----------------PEPAADEHELTPPP------EELDHVSGASD----------- 325

  Fly   257 ACQAGPEHSKANPITGPAAGAPSAKPAPNAPQAIIMEPSRELAEQTYNQ-IEKFKYHLSNPEVRS 320
              :......:|..:..|..|             :::.|:||||.|..|. :...||    ..:|.
  Fly   326 --EESDAEEQAQRVQTPLYG-------------LVLTPTRELAVQVKNHLVAAAKY----TGIRV 371

  Fly   321 LLLIGGVRLEEQKAQLMQGTHIVVGTPGRLEEMINSG---LVLLTHCRFFVLDEADALLKQGYTE 382
            ..:.||:.:.:|:..|.|...|||.|||||.|:...|   |..:....|.|:||.|.::::|:.|
  Fly   372 AAIFGGLAVAKQERVLRQCPDIVVATPGRLWELYAQGNRHLGKIEDVSFLVIDETDRMVEKGHFE 436

  Fly   383 LIDRLHKQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMH-FPTWVDLKGEDAVPETVHHVVC 446
            .:..|.|.:........:.|..|.||||          .|:| .|..:..:.....|:.|...|
  Fly   437 ELRSLLKVLNSDEQKKHQRQNFVYSATL----------TLVHDLPDHMQKRNVGKRPKFVKQTV- 490

  Fly   447 LVDPQMDTTWQSLRQPIGTDGVHDRDNVHPGNHSKETLSQAVKLL-----KGEYCVHAIDKHNMD 506
                  |...:||.:.:|.......| :.....:.:||::: :||     |..:..:.|.:| ..
  Fly   491 ------DQKIESLIEELGISQPKIVD-ITSSQQTAQTLTES-RLLCPIDHKDYHLYYFIQRH-PG 546

  Fly   507 RAIIFCRTKQDCDNLERFLRQRGGKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTDVAARG 571
            |.|:||.: .||  ::|.....|....:.:.||.:...::|.:|||.|:......||.|||||||
  Fly   547 RTIVFCNS-IDC--VKRLATLFGLLDCNPLPLHANMIQKQRLKNLERFRDSPTGLLIATDVAARG 608

  Fly   572 LDITGLPFMINVTLPDDKTNYVHRIGRVGRAERMGLAISLVATVPEKVWYHGEWCKSRGRSCNNT 636
            |||..:..:|:..:|....|||||.||..||.:.|:.
  Fly   609 LDIPNVEHVIHYQVPRTSENYVHRSGRTARANKHGIT---------------------------- 645

  Fly   637 NLTEVRGCCIWYNEPNLLAEVEDHLNITIQQVDKTMDVPVNDFDGKVVYGQKNLRTGSGYEDHVE 701
                     :.:.||   .||:.::.: .:.:::|.|:|:...                    :|
  Fly   646 ---------VMFMEP---GEVKSYVKL-YKTLERTEDLPLFPI--------------------LE 677

  Fly   702 QLVPTVRKLTEL--ELQSQSLFLKRLK 726
            :.:..||:...|  :|..:.|.|||::
  Fly   678 RFMGAVRERVNLARDLDKEELKLKRVQ 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddx1	NP_524212.2	P-loop_NTPase	4..>62	CDD:304359	25/58 (43%)
		SPRY_DDX1	91..242	CDD:293933	12/153 (8%)
		SrmB	279..>612	CDD:223587	98/342 (29%)
		P-loop_NTPase	<280..426	CDD:304359	43/150 (29%)
		Helicase_C	492..602	CDD:278689	39/109 (36%)
CG9143	NP_611467.1	BLVR	<125..191	CDD:283923
		SrmB	201..747	CDD:223587	160/742 (22%)
		P-loop_NTPase	217..465	CDD:304359	85/424 (20%)
		HELICc	531..648	CDD:238034	42/157 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040