DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ddx1 and Hel25E

DIOPT Version :9

Sequence 1:	NP_524212.2	Gene:	Ddx1 / 40457	FlyBaseID:	FBgn0015075	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	99/396 - (25%)
Similarity:	177/396 - (44%)	Gaps:	93/396 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 NAPQAIIMEPSRELAEQTYNQIEKFKYHLSNPEVRSLLLIGGVRLEEQKAQLMQGT-HIVVGTPG 348
            |....::|..:||||.|...:.|:|..::  |.|:..:..||:.:::.:..|..|| ||||||||
  Fly   109 NTCHVLVMCHTRELAFQISKEYERFSKYM--PTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPG 171

  Fly   349 RLEEMINS---GLVLLTHCRFFVLDEADALLKQGYTELID--RLHKQIPKITSDGRRLQMVVCSA 408
            |:..:|.:   .|.||.|   |||||.|.:|:|     :|  |..::|.:.|..|:  |:::.||
  Fly   172 RILALIRNKKLNLKLLKH---FVLDECDKMLEQ-----LDMRRDVQEIFRSTPHGK--QVMMFSA 226

  Fly   409 TLHAFEVKKMAERLMHFPTWVDLKGEDAVPETVHHVVCLVDPQMDTTWQSLRQPIGTDGVHDRDN 473
            || :.:::.:.::.|..|..|                 .||.:...|...|:|..    |:.::|
  Fly   227 TL-SKDIRPVCKKFMQDPMEV-----------------YVDDEAKLTLHGLQQHY----VNLKEN 269

  Fly   474 VHPGNHSKETLSQAVKLLKGEYCVHAIDKHNMDRAIIFCRTKQDCDNLERFLRQRGGKHYSCVCL 538
            .                 |.:.....:|....::.:||.::.|.|..|.:.|.:   :::..:.:
  Fly   270 E-----------------KNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTE---QNFPAIGI 314

  Fly   539 HGDRKPQERKENLEMFKRQQVKFLICTDVAARGLDITGLPFMINVTLPDDKTNYVHRIGRVGRAE 603
            |.....:||....:.||..|.:.|:.|::..||:||..:..:.|..:|:|...|:||:.|.||..
  Fly   315 HRGMTQEERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFG 379

  Fly   604 RMGLAISLVATVPEKVWYHGEWCKSRGRSCNNTNLTEVRGCCIWYNEPNLLAEVEDHLNITIQQV 668
            ..||||:.|:.                                 .|:..:|.||:|..::.|.::
  Fly   380 TKGLAITFVSD---------------------------------ENDAKILNEVQDRFDVNISEL 411

  Fly   669 DKTMDV 674
            .:.:|:
  Fly   412 PEEIDL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddx1	NP_524212.2	P-loop_NTPase	4..>62	CDD:304359
		SPRY_DDX1	91..242	CDD:293933
		SrmB	279..>612	CDD:223587	91/332 (27%)
		P-loop_NTPase	<280..426	CDD:304359	49/146 (34%)
		Helicase_C	492..602	CDD:278689	28/109 (26%)
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	51/168 (30%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	37/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930