Protein Alignment Rich and RIC1

DIOPT Version :9

• Sequence 1: NP_001262205.1
• Gene: Rich / 40456
• FlyBaseID: FBgn0028500
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: NP_013140.1
• Gene: RIC1 / 850728
• SGDID: S000004029
• Length: 1056
• Species: Saccharomyces cerevisiae
• Alignment Length: 1207
• Identity: 202/1207 - (16%)
• Similarity: 350/1207 - (28%)
• Gaps: 537/1207 - (44%)

  Fly    44 IWYANPLIPIAYFRRTEDSLRQYGANQL-------------IVWKPDSRQLA---------LLTA 86
            |:...|:..:|...||..||:::|.|:.             ::.|.||:.|.         ::|.
Yeast    90 IYNFKPMALVASHERTMASLKEFGDNRSMKRSAPYNDIIEGLISKKDSQYLLWHQGKLIFYVMTD 154

  Fly    87 SGSLLLYQ--------LDFEANGMGILQQI-----------------DPPAASLKRDSAELFI-- 124
            ...||.||        :.|:..|:.:::.:                 |.......::|:...|
Yeast   155 KNFLLTYQILKNCTNEIIFKEYGIPVIEPLLMSEEEANSAEYDYNNDDDTLTVFDKNSSSRIIQN 219

  Fly   125 ----------------KENIPRLSLREL---CSVTL----------------------------- 141
                            :|||..|.:::|   ..|.|
Yeast   220 GFGITKEKGFLHFLSNQENIDELPVKKLELRLKVVLKFDYEIIDMIGIKTFSKVGDGRYEEVLIV 284

  Fly   142 ----GSVITTVCCISLSELLLA-------TQSC--ELLRLQWTELEH----AENDLELPALSSIK 189
                |..|.|:....:|:..|.       |..|  :|:.|....:|.    :..|:|..|:.:|.
Yeast   285 LFPHGLQILTISDFKVSKSSLVEVKKGSKTIVCNKQLMVLSHDSVEKQTIVSIIDIEKQAVEAIP 349

  Fly   190 LRDIPFYVQQQPQQSARNVPPLNRDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMH 254
            |.|.|                   |..:..||.:.::   ..|:.::...|
Yeast   350 LTDTP-------------------DELLTCLEVNGYL---VVVYKEKIICF-------------- 378

  Fly   255 GFWVPDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPDSLGSVNE 319
                    |..:..|:|
Yeast   379 --------DTRIKKVSH------------------------------------------------ 387

  Fly   320 LKWSP-----------DGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLN-------------- 359
             .|.|           |..:|.||..:..:..::.||.||.:|...:...|
Yeast   388 -SWKPPFVIKLCDKINDKILLLVSEDSVNIHFYTEFGNLLFATYFDEDDYNGDNNNDNSKDKNEK 451

  Fly   360 -------VDLVCQNPLKIRRLEWSTEG-YQLFMLKLHPEKDKSNVLQLQFVKSALSMNPCMTTSP 416
                   .|.||   |....:..|..| ||::  ||..|     :.|.||.    ..||
Yeast   452 KAAEYKISDFVC---LDKSLITVSHSGKYQVW--KLWEE-----IKQTQFD----FRNP------ 496

  Fly   417 HILLQGDDCLYLNQGNNLELTYAGSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYW 481
                   .|..|...||..:.|                             ||.|.|.:.....
Yeast   497 -------KCYVLTNTNNDVIIY-----------------------------SPVTSSSINNDNL- 524

  Fly   482 TVLQLP-------LNYAATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDF 539
            .|::||       :.:...|..:|..|       ..|:.:..|..::|.|..|..|.:::
Yeast   525 QVIKLPTKTFNNHIAFVKINSSLRLFA-------TYVSNKNILLIHNLETNMWSSFADQN----- 577

  Fly   540 VVSGGLLWWHGFVVMGCYSLL-DRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLT 603
            |:.   |.|.|...:.|:... |.:..|:|...          .||...|.:.|
Yeast   578 VLD---LHWLGDNYLVCHMKNDDGSTNLKCLQI----------PLQEANPDVEL----------- 618

  Fly   604 ADGIVSLFNMSKNSAYALDIECAYELDVKSICIHPACIVSLTVTNLKNE--LKPQGQLGGDQAET 666
            :|.::..:|:.:|:                      .:.||.|..|...  ||.:.:
Yeast   619 SDYVMWEYNVPENT----------------------IVFSLHVNTLSRYKLLKMKSK-------- 653

  Fly   667 IIVNVCGRILMIQRDAGEQVPNTLLATCLASCVE-----VFWLSHSLERCAMRDCLWLYSGAHGM 726
                        ..:|.|:.|:.||.|.....|.     ||.:..::..|.:......|   ..:
Yeast   654 ------------NHNASEKQPDALLKTAEIILVTDTQTIVFDVISTVHPCGLNIIKKFY---QYL 703

  Fly   727 RVWLPI--LPPGRE----RREG---------------EQGGAQRL-------------------- 750
            ::.:||  ||...|    .:||               :.||.|.|
Yeast   704 KINIPIDVLPNKIEWIINMKEGLLFFADRKFIKLGKVDGGGWQTLTLLDNIEKIIDVIRDEIFVV 768

  Fly   751 --HSFM---------SKRIMLSFPLK--LYPLVVLFDNVIVLGVENESTLYANEQVSH--FSLPF 800
              |:::         .|:.::|.|::  |||:             :.:...|.....|  |:..|
Yeast   769 QGHNYVVYSLEDLWDDKKPLVSIPIEEDLYPI-------------STTPETATTHTLHCIFNARF 820

  Fly   801 AVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLH-EVLEEEATSKQPIPD 864
            :.:..|.||||.:::...::.|....  :::.:...|..:..|||.:|. ::|..::
Yeast   821 SKLVVKHQIYLDQLILAKLEDNTDLE--DISHNYRFLKPYKFALEKILSTKILRSDS-------- 875

  Fly   865 AQLPSILDFIREF-----------PVY---LETIVQCARKTEIALWPYLF-SMAGKPKDLFQMCL 914
              |..||..|:.:           |.:   ||.|..|.||.|...|.:|| ::...|:||..:|:
Yeast   876 --LDDILKLIKMYDNTDPEHNISPPTHSGMLEIISNCLRKIETKYWNHLFTNLKMTPRDLLALCI 938

  Fly   915 QSEQLDTAASYLIILQNLEPSVV---------------------------SKQYATMLLDIALQQ 952
            :..:.......|::..|.:...:                           .|....:|.|..|..
Yeast   939 EENEAKMLGVLLLVFLNYDEKDLGDDLHFKKSDLGTEESKALNDNSTKKSEKSVTNLLKDEELML 1003

  Fly   953 R--------------------KWELAKDLIRFLKAID 969
            :                    .|::...|||.||.:|
Yeast  1004 KVLELLVTSAANATDPIKATDSWDMCFQLIRLLKELD 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rich	NP_001262205.1	WD40 repeat	265..312	CDD:293791	2/46 (4%)
		RIC1	713..974	CDD:284476	67/376 (18%)
RIC1	NP_013140.1	RIC1	<820..1045	CDD:399802	45/233 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2006
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22746
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000