DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rich and RIC1

DIOPT Version :9

Sequence 1:	NP_001262205.1	Gene:	Rich / 40456	FlyBaseID:	FBgn0028500	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_065880.2	Gene:	RIC1 / 57589	HGNCID:	17686	Length:	1423	Species:	Homo sapiens

Alignment Length:	1474	Identity:	511/1474 - (34%)
Similarity:	780/1474 - (52%)	Gaps:	196/1474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQ 65
            ||:..|||||:...|...:.:..|:..|..:...|.:....|.|||:.|.:.|..::....|..|
Human     1 MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPSVLIVTYKEPAKSSTQ 65

  Fly    66 YGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKENIPR 130
            :|:.:...|:|||..:|:.||:|.:|.:.:........:.:.:.|..:...:.:.....::..|.
Human    66 FGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPA 130

  Fly   131 LSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIPF 195
            |:|.....:.|.:.|.::..: |.:||:||....|..:.|..:.:..        .:|.|..:||
Human   131 LNLEMRKILDLQAPIMSLQSV-LEDLLVATSDGLLHLIHWEGMTNGR--------KAINLCTVPF 186

  Fly   196 YVQQQPQQSARNVPPLN-RDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWVP 259
            .|.   .||:|....|. .|.::..:||...:.|.|.||:|.:..|:.....||..:.:||.|..
Human   187 SVD---LQSSRVGSFLGFTDVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQ 248

  Fly   260 DVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPD---SLGSVNELK 321
            ||.|.:..:||:|:||:|:|..|.:|:||.||::||.:..||:|.||....||   ..|:|..::
Human   249 DVVDGTCVAVNNKYRLMAFGCVSGSVQVYTIDNSTGAMLLSHKLELTAKQYPDIWNKTGAVKLMR 313

  Fly   322 WSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFMLK 386
            ||||..|:.|:|..|||||||.|||.|:.||..||....|...::||||..:.|..|||.|:::.
Human   314 WSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVIS 378

  Fly   387 ------------LHPEKDKSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLNQGNNLELTYA 439
                        |.....:.::|..||:||.|::||||:....:||||:|.||||.|...:....
Human   379 GFGSQNTEIESDLRSVVKQPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQTQNP 443

  Fly   440 GSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYAATNWPIRYAAIDP 504
            .|..|........::....||. ||.:..    |.|...::|.|:|:...|..:|||||::|||.
Human   444 RSSSTHSEHKPSREKSPFADGG-LESQGL----STLLGHRHWHVVQISSTYLESNWPIRFSAIDK 503

  Fly   505 DGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGCYSLLDRTDELRCY 569
            .|.::||.|:.|.|||||:|::||||||.:||::.:|:|||.||:.|:|:.||::.||.:|||.|
Human   504 LGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFMVLACYNINDRQEELRVY 568

  Fly   570 PADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSKNS---AYALDIECAYELDV 631
            .....|||.:.|..:.:|..:.|:.|:..:||..||..:.|:::.:.|   .....|:...|:.:
Human   569 LRTSNLDNAFAHVTKAQAETLLLSVFQDMVIVFRADCSICLYSIERKSDGPNTTAGIQVLQEVSM 633

  Fly   632 KSICIHPACIVSLTVTNLKNE----LKPQGQLGGDQAETIIVNVCGRILMIQRD-AGEQV----- 686
            .....||..:||:|:|::..|    ||...|..|  ||:|::|:.|:::|:||| :|.|:
Human   634 SRYIPHPFLVVSVTLTSVSTENGITLKMPQQARG--AESIMLNLAGQLIMMQRDRSGPQIREKDS 696

  Fly   687 -PNT---LLATC----LASCVEVFWLS--------HSLERCAMRDCLWLYSGAHGMRVWLPILPP 735
             ||.   ||..|    ||..||..|.:        |.||      .|||..|..||:||||:.|
Human   697 NPNNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLE------ALWLSCGGAGMKVWLPLFP- 754

  Fly   736 GRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLY--------ANEQ 792
             |:.|        :.|||:|:||||.|.:.:|||.|||::.:|||..|::.||        |.||
Human   755 -RDHR--------KPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYTRNNAREQ 810

  Fly   793 VSHFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEAT 857
            : ....||.|:||.||||||.:||||:.||||..|..:||||.:||||||.|||:||||||||||
Human   811 L-EVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEAT 874

  Fly   858 SKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTA 922
            |::||||..||::..||.|||::|:|:|.||||||.|||.|||:..|.|||||:.||.::.||||
Human   875 SREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTA 939

  Fly   923 ASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDSPRSSMVVNVKIA 987
            |||||||||:|...||:|:||:|.:.||:|.||:|.:.:|||||||...|.::
Human   940 ASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESET------------ 992

  Fly   988 PPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTS-NLPKDK--------QASGTPGVAPVTE 1043
             ||...|.|:.: ::..|...     |.||.|.:.:: |:|..|        ..||..|.....:
Human   993 -PPSTPTAQEPS-SSGGFEFF-----RNRSISLSQSAENVPASKFSLQKTLSMPSGPSGKRWSKD 1050

  Fly  1044 SSSAGAPSVVRRRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLSQESERA 1108
            |..|              |...||::|.||||:||::.:|.|||...|.|.|.|:|||.:|..||
Human  1051 SDCA--------------ENMYIDMMLWRHARRLLEDVRLKDLGCFAAQLGFELISWLCKERTRA 1101

  Fly  1109 AKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTG-------------------GGGS 1154
            |::|:|..||:.||::...|:|...|:........|..|..|                   |..:
Human  1102 ARVDNFVIALKRLHKDFLWPLPIIPASSISSPFKNGKYRTVGEQLLKSQSADPFLNLEMDAGISN 1166

  Fly  1155 SQTSESGYFSLATP-----NGAATQSPQLQPS----IREEEEELQQPSSLPILKTRSGSQLSFD- 1209
            .|.|:| :.|...|     :.|::..||:|.:    :..:.:|....|:..:  |.|.|.:..|
Human  1167 IQRSQS-WLSNIGPTHHEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDL--TESSSMVDGDW 1228

  Fly  1210 -----NFRYRRLYSLPTSE-DDLAVDIL---PQKLSIKLRYLLQLFIEANCTDYALVLSILLQDA 1265
                 ||   ...||..|| :.:::::.   |.|..::|||||.:|:||.|.|:.:|:.::|:::
Human  1229 TMVDENF---STLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRES 1290

  Fly  1266 ASISRIVNGIIRSESV--HTCRRTESALKQLSQ-STFEHSGSLYRGFVLTLQPHVYLL----EQY 1323
            :.|::|: .|.:|..|  ...:..::.|..:.: ::.:..|  |:.|:..::|.:..|    |:.
Human  1291 SIINQIL-VITQSSEVDGEMLQNIKTGLHAVDRWASTDCPG--YKPFLNIIKPQLQKLSEITEEQ 1352

  Fly  1324 IQ-------SLGDAPCSQLQDAGPGTEQGVDVSTGLQGLQNEVG 1360
            :|       ::|..|    :...|..|:....|:.....|.|||
Human  1353 VQPDAFQPITMGKTP----EQTSPRAEESRGSSSHGSIPQGEVG 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rich	NP_001262205.1	WD40 repeat	265..312	CDD:293791	20/46 (43%)
Rich	NP_001262205.1	RIC1	713..974	CDD:284476	149/268 (56%)
RIC1	NP_065880.2	WD 1	64..103		11/38 (29%)
		WD 2	304..343		20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..463		2/25 (8%)
		RIC1	733..990	CDD:284476	150/273 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1423		9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148183
Domainoid	1	1.000	396	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E1_KOG2006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13806
Inparanoid	1	1.050	759	1.000	Inparanoid score	I552
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55710
OrthoDB	1	1.010	-	-		D261419at2759
OrthoFinder	1	1.000	-	-		FOG0003567
OrthoInspector	1	1.000	-	-		oto89214
orthoMCL	1	0.900	-	-		OOG6_103873
Panther	1	1.100	-	-	LDO	PTHR22746
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770