Protein Alignment Rich and Ric1

DIOPT Version :10

• Sequence 1: NP_649385.1
• Gene: Rich / 40456
• FlyBaseID: FBgn0028500
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: NP_001074788.1
• Gene: Ric1 / 226089
• MGIID: 1924893
• Length: 1422
• Species: Mus musculus
• Alignment Length: 1496
• Identity: 515/1496 - (34%)
• Similarity: 788/1496 - (52%)
• Gaps: 215/1496 - (14%)

  Fly     1 MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQ 65
            ||:..|||||:..|....:.:..|:..|..:...|.:....|.|||:.|.:.|..::....|..|
Mouse     1 MYFLSGWPKRLLCAPRSPAEAPLHVQSDPRRAFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSTQ 65

  Fly    66 YGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKEN-IP 129
            :|:.:...|:|||..:|:.||:|.:|.:.:. .:.|...|.:...|..|.:......|.:|: .|
Mouse    66 FGSYKQAEWRPDSTMIAVSTANGYILFFHIT-SSRGDKYLYEPVYPKGSPQMKGIPHFKEEHCAP 129

  Fly   130 RLSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIP 194
            .|:|.....:.|.:.|.::..: |.:||:||....|..:.|..:.:..        .:|.|..:|
Mouse   130 ALNLEMKKILDLQAPIMSLQSV-LEDLLVATSDGLLHLIHWEGMTNGR--------KAINLSTVP 185

  Fly   195 FYVQQQPQQSARNVPPLN-RDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWV 258
            |.|.   .||:|....|. .|.::..:||...:.|.|.||:|.:..|:.....||..:.:||.|.
Mouse   186 FSVD---LQSSRVGSFLGFADVHIKDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWP 247

  Fly   259 PDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPD---SLGSVNEL 320
            .||.|.:..:||:|:||:|:|..|..|:||.||:.||.:..||:|.||....||   ..|:|..:
Mouse   248 QDVIDGTCVAVNNKYRLMAFGCASGCVQVYTIDNTTGAMLLSHKLELTAKQYPDIWNKTGAVKLI 312

  Fly   321 KWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFML 385
            :||||...:.|:|..|||||||.|||.|:.||..||....|...::||||..:.|..|||.|:::
Mouse   313 RWSPDNSAVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVI 377

  Fly   386 K------------LHPEKDKSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLN-----QGNN 433
            .            |.....:.::|..||:||.|::||||:....:||||:|.||||     |..|
Mouse   378 SGLGSQHTQIETDLRSTVKEPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQAQN 442

  Fly   434 LELTYAGSH-------GTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYA 491
            .:.:.|.:.       ..|...||                ::|...::|.. ::|.|:|:...|.
Mouse   443 PKYSSARAERMPRHEKSPFADGGL----------------EAPGLSTLLGH-RHWHVVQISSTYL 490

  Fly   492 ATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGC 556
            .:|||||::|||..|.::||||:.|.|||||:|::||||||.:||::.:|:|||.||..|:|:.|
Mouse   491 ESNWPIRFSAIDKLGQNIAVAGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWDDFMVLAC 555

  Fly   557 YSLLDRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNM---SKNSA 618
            |:|.||.:|||.|.....|||.:.|..:.....:.|:.||..::|..||..:.|:::   |..|.
Mouse   556 YNLSDRQEELRIYLRTSNLDNAFAHVTKAPMETLLLSVFRDMVVVFRADCSICLYSIERKSDGSN 620

  Fly   619 YALDIECAYELDVKSICIHPACIVSLTVTNLKNE----LKPQGQLGGDQAETIIVNVCGRILMIQ 679
            ....::...|:.:.....||..:||:|:|::..|    ||...|  ...||:|::|:.|:::|:|
Mouse   621 TTASVQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGISLKMPQQ--ARDAESIMLNLAGQLIMMQ 683

  Fly   680 RD-AGEQV------PN--TLLATC----LASCVEVFWLS--------HSLERCAMRDCLWLYSGA 723
            || :|.|:      ||  .||..|    ||..||..|.:        |.||      .|||..|.
Mouse   684 RDRSGPQIREKDSHPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLE------ALWLSCGG 742

  Fly   724 HGMRVWLPILPPGRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLY 788
            .||:||||:.|  |:.|        :.|||:|:||||.|.:.:|||.|||::.:|||..|::.||
Mouse   743 AGMKVWLPLFP--RDHR--------KPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLY 797

  Fly   789 --------ANEQVSHFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALE 845
                    |.||: ....||.|:||.||||||.:||||:.||||..|..:||||.:||||||.||
Mouse   798 DSLYTRSSAREQL-EVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLE 861

  Fly   846 LLLHEVLEEEATSKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLF 910
            |:|||||||||||::||||..||::..||.|||::|:|:|.||||||.|||.|||:..|.|||||
Mouse   862 LMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLF 926

  Fly   911 QMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDS 975
            :.||.::.|||||||||||||:|...||:|:||:|.:.||:|.||:|.:.:|||||||...|.::
Mouse   927 EECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESET 991

  Fly   976 PRSSMVVNVKIAPPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTS-NLPKDKQASGTPGVA 1039
                         ||...|.|:.: ::..|...     |.||.|.:.:: |:|        ||..
Mouse   992 -------------PPSTPTSQEPS-SSGGFEFF-----RNRSISLSQSAENVP--------PGKF 1029

  Fly  1040 PVTES-SSAGAPSVVR-RRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLS 1102
            .:.:: |....||..| .:.::..|...||::|.||||:||:..:|.|||...|.|.|.|:|||.
Mouse  1030 GLQKTLSMPTGPSGKRWSKDSECAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLC 1094

  Fly  1103 QESERAAKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTG----------------- 1150
            :|..|||::|:|..||:.||::...|:|...|:........|..|..|
Mouse  1095 KERTRAARVDNFVVALKRLHKDFLWPLPIIPASSISSPFKNGKCRAVGEQMLKSQSADPFITPEM 1159

  Fly  1151 --GGGSSQTSESGYFSLATP-----NGAATQSPQLQPS----IREEEEELQQPSSLPILKTRSGS 1204
              |..:.|.|:| :.|...|     :.|::..||:|.:    :..:.:|....|:..:  |.|.|
Mouse  1160 DAGISNIQRSQS-WLSNIGPTHRDTDRASSPGPQMQDAFLSPLSNKGDECSIGSATDL--TESSS 1221

  Fly  1205 QLSFD------NFRYRRLYSLPTSE-DDLAVDIL---PQKLSIKLRYLLQLFIEANCTDYALVLS 1259
            .:..|      ||   ...||..|| :.:::::.   |.|..::|||||.:|:||.|.|:.:|:.
Mouse  1222 VVDGDWTMVDENF---STLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCVVIG 1283

  Fly  1260 ILLQDAASISRIVNGIIRSESV--HTCRRTESALKQLSQ-STFEHSGSLYRGFVLTLQPHVYLL- 1320
            ::|::::.:|::: ||.:|..:  ...:..:|.|:.:.: ::.:..|  |:.|:..::|.:..|
Mouse  1284 LILRESSVVSQLL-GIAQSSEMDGEMLQNIKSGLQAVDRWASTDCPG--YKPFLNIIKPQLQKLS 1345

  Fly  1321 ---EQYIQ-------SLGDAPCSQLQDAGPGTEQG------VDVSTGLQGLQNEVGEFVPNSQQA 1369
               |:.:|       ::|..|    :...|..|:.      ..:|....|..|.|.....::.||
Mouse  1346 EITEELVQPDTFQPVTVGKTP----EQTSPRAEENRGSCSHGSISQSEPGSNNVVSRKEEDTTQA 1406

  Fly  1370 N 1370
            :
Mouse  1407 D 1407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rich	NP_649385.1	WD40 repeat	265..312	CDD:293791	20/46 (43%)
		WD40	<274..>353	CDD:441893	39/81 (48%)
		RIC1	714..971	CDD:462078	148/264 (56%)
Ric1	NP_001074788.1	WD 1	64..103		12/39 (31%)
		WD40 repeat	254..304	CDD:293791	22/49 (45%)
		WD 2	304..343		19/38 (50%)
		WD40 repeat	310..350	CDD:293791	21/39 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..462		2/19 (11%)
		RIC1	732..988	CDD:462078	150/272 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	986..1005		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1021..1048		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1198		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1355..1422		10/57 (18%)