DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rich and ric1

DIOPT Version :9

Sequence 1:	NP_001262205.1	Gene:	Rich / 40456	FlyBaseID:	FBgn0028500	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	XP_021326517.1	Gene:	ric1 / 100330980	ZFINID:	ZDB-GENE-121005-4	Length:	1197	Species:	Danio rerio

Alignment Length:	1292	Identity:	445/1292 - (34%)
Similarity:	660/1292 - (51%)	Gaps:	173/1292 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQ 65
            ||:..|||:|:...|..:....| |...|.:..:|.:.:..:.||::.|.:.|..:..:..:..|
Zfish     1 MYFLSGWPRRLLCPLRSDERPFR-IEPSAQRFYLAVLSETQISIWFSRPSVLIVSYIESGKAAAQ 64

  Fly    66 YGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKENIPR 130
            :|..|.:.||||...:|:..|:|.:||:.:....:...:.:.:.|..::..:.:.....::..|.
Zfish    65 FGFYQQVEWKPDDSMIAVAAANGYVLLFDIIGGLDDKYLYEPVYPKGSARVKVTPGYKEEQCAPA 129

  Fly   131 LSLRELCSVTLGSVITTVCCISLSE-LLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIP 194
            |:|.....|.|.:.|:  |..||:| ||:||....|..|.|..:.:...        ::.|..||
Zfish   130 LTLEMKKPVDLEAPIS--CLQSLAEDLLVATADGFLHMLHWDSVSNGRR--------AVNLCTIP 184

  Fly   195 FYVQQQPQQSARNVPPLNRDS-YVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWV 258
            |.:.   .||:|..|.|:.|. |:..|||...:.|.|.||.|.|..|:.....|..||.:.|.|.
Zfish   185 FSLD---LQSSRGGPCLDLDGVYIRDLEYCATLDGFAVVFDDGRIGFITPTANRLATDQLQGVWA 246

  Fly   259 PDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPD---SLGSVNEL 320
            .||.|.:..:||:|:||:|:|..|.:|.||.||.:||.::.||:|.||....||   ..|.|..:
Zfish   247 ADVTDGTCVAVNNKYRLMAFGCTSGSVLVYMIDSSTGCMQLSHKLELTPKHYPDIWNKTGPVKMI 311

  Fly   321 KWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFML 385
            :||||..|..|:|..|||||||.|||.|:.||..||....|...::||||..:.|..|||.|:::
Zfish   312 RWSPDCSVAMVTWECGGLSLWSVFGAHLICTLGEDFAYRSDGTKKDPLKISSMSWGVEGYHLWVI 376

  Fly   386 K-----LHPEK----DKSNVLQLQFVKSALSMNPCM-------TTSPHILLQGDDCLYLNQGNNL 434
            :     :..||    .::.:||.||:||.:|:..|:       :....:||||:|.||:..|:..
Zfish   377 RSSDSTVTEEKQEKLQQNTILQFQFIKSYVSLCMCLCVCVRVQSNQEQVLLQGEDRLYVTCGDPT 441

  Fly   435 ELTYAGSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYAATNWPIRY 499
            : |.........||...|...:........|.|...|   |...|:|.|:|:...|..||||||
Zfish   442 Q-TQTPGQCVLDSSSSSSSSPVQRSSSTAPLSQGLST---LLGHKHWQVVQIHSTYLETNWPIR- 501

  Fly   500 AAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGCYSLLDRTD 564
                                                |::..|:|||.||:.|||:.||:.:||.:
Zfish   502 ------------------------------------EQNMTVTGGLAWWNDFVVVACYNFIDRQE 530

  Fly   565 ELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSK---NSAYALDIECA 626
            |||.|.....|||.:....::.|..:.||.||:.:|:..||..:.|:::.:   ..:.:..:|..
Zfish   531 ELRLYVRSANLDNAFASITKLHADTLLLNVFRNMVILFRADCSICLYSIERRHDGPSPSASVELL 595

  Fly   627 YELDVKSICIHPACIVSLTVTNLKNE----LKPQGQLGGDQAETIIVNVCGRILMIQRD-AGEQV 686
            .|:.:.....||..:||:|:|:::.|    ||...|  ...||:|::|:.|:::|:||| :|.||
Zfish   596 QEVSMSRYIPHPGLVVSVTLTSVRTESGITLKAPQQ--ACSAESILLNLAGQLIMLQRDRSGPQV 658

  Fly   687 --------PNTLLATC----LASCVEVFWLSHSLERCA--MRDCLWLYSGAHGMRVWLPILPPGR 737
                    .:.||..|    ||.|||..|.|....|..  :.:.|||..|..||:||||:.|  |
Zfish   659 REKDAPANHSKLLPFCPPVVLAQCVESVWTSSRSNRKKRHLMEALWLSCGEAGMKVWLPLFP--R 721

  Fly   738 ERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLY----ANEQVSHFSL 798
            :.|        :.|||:|:||||.|.:.:|||.|||::.::||..||:.|:    ::.:......
Zfish   722 DHR--------KPHSFLSRRIMLPFHINIYPLTVLFEDALILGASNETVLFDGLSSSAEPLEALF 778

  Fly   799 PFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIP 863
            |:..:||.||||||.:||||:.||||..|..:||||.|||||||.|||::|.||||||||::|||
Zfish   779 PYCTVERTSQIYLHHILRQLLVRNLGEQALMLAQSCASLPYFPHVLELMVHVVLEEEATSREPIP 843

  Fly   864 DAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLII 928
            |..||::..|:.|||::|:|||.||||||.|||.|||:..|.|||||:.||.::.||||||||||
Zfish   844 DPLLPTVAKFVTEFPLFLQTIVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLII 908

  Fly   929 LQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDSPRSSMVVNVKIAPPPQVN 993
            |||:|...||:|:||:|.:.||:|.||:|.:.:|||||||...|.::            ||....
Zfish   909 LQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESET------------PPTTPT 961

  Fly   994 TQQQVNQNADAFNMVLGPIARERSFSTTVTSNLPKDKQASGTPGV-----APVTESSSAGAPSVV 1053
            ||:|...:...|       .|.||.|.:.::    |..|:|...:     .|...||.:|
Zfish   962 TQEQSPSSGFEF-------FRNRSISLSQSA----DSIAAGKFNLQKTMSMPTGPSSKSG----- 1010

  Fly  1054 RR--RSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLSQESERAAKLDDFAG 1116
            .|  :.:...|...||::|.||||:||:..:|.|||...|.|.|.|:.||.:|..|.|::|||..
Zfish  1011 ERWCKDSDSAENLYIDVMLWRHARRLLEQVRLRDLGCFSAQLGFELIGWLCRERTRVARVDDFVT 1075

  Fly  1117 ALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTGGGG--SSQTSESGYFS--------LATPN-- 1169
            ||:.||::...|.|...|.........|..|......  .||:::|...|        ::|.|
Zfish  1076 ALKCLHKDFLWPFPVIPACTISSPLKNGRCRPVLSSRLLKSQSADSLLNSEMDTTPPQVSTANHR 1140

  Fly  1170 ---GAATQSPQLQPSIREEEEELQQPSSLPILKTRSGSQLSFDNFRY------RRLY 1217
               |....|.:|..:......:.|:....|::.  .|.|:| |.:.|      |.:|
Zfish  1141 WLDGLGAVSKELDSASSHGGPQTQEAFLSPLIS--KGEQVS-DIYLYFHPSIHRSIY 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rich	NP_001262205.1	WD40 repeat	265..312	CDD:293791	20/46 (43%)
Rich	NP_001262205.1	RIC1	713..974	CDD:284476	142/264 (54%)
ric1	XP_021326517.1	RIC1	699..953	CDD:311180	141/263 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582107
Domainoid	1	1.000	324	1.000	Domainoid score	I1179
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13806
Inparanoid	1	1.050	655	1.000	Inparanoid score	I757
OMA	1	1.010	-	-		QHG55710
OrthoDB	1	1.010	-	-		D261419at2759
OrthoFinder	1	1.000	-	-		FOG0003567
OrthoInspector	1	1.000	-	-		oto39650
orthoMCL	1	0.900	-	-		OOG6_103873
Panther	1	1.100	-	-	LDO	PTHR22746
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3432
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910