Protein Alignment Rich and ric1

DIOPT Version :9

• Sequence 1: NP_001262205.1
• Gene: Rich / 40456
• FlyBaseID: FBgn0028500
• Length: 1429
• Species: Drosophila melanogaster
• Sequence 2: XP_004910849.1
• Gene: ric1 / 100170625
• XenbaseID: XB-GENE-1001477
• Length: 1421
• Species: Xenopus tropicalis
• Alignment Length: 1549
• Identity: 519/1549 - (33%)
• Similarity: 792/1549 - (51%)
• Gaps: 263/1549 - (16%)

  Fly     1 MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQ 65
            ||:..|||||:...|....... ||..|:.:|..:.:....|.|||:.|.:.||.::.:..:..|
 Frog     1 MYFLSGWPKRLLCPLKTVEKPF-HIQPDSQRIFFSVLSQTQLSIWYSRPSVLIASYKESAKATAQ 64

  Fly    66 YGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDP---PAASLKRDSAELFIKEN 127
            :|..:...|:|||..:.:.||:|.:|.:.:........:.:.:.|   |...|.....|   ::.
 Frog    65 FGNYKQAEWRPDSSMIVIATANGYILFFDIIPVGEDKYLYEPVYPKGSPHIKLNPHYKE---EQC 126

  Fly   128 IPRLSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRD 192
            .|.|:|.....:.|.:.||::..: :.:||:||:...|..:.|..:.:..        .:|.|..
 Frog   127 APALNLETKKVMDLQASITSIQSM-MEDLLVATEDGLLHIIHWEGMTNGR--------KAINLTT 182

  Fly   193 IPFYVQQQPQQSARNVPPLNRDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFW 257
            |||.:..||.::...:.  ..|.::..:||...:.|.|.||:|.|..|:.....|...|.:||.|
 Frog   183 IPFSIDFQPSRAGSFLD--FGDVHIRDMEYCATLDGFAVVFNDGRVGFITPGSNRLTADQIHGVW 245

  Fly   258 VPDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPD---SLGSVNE 319
            .|||.|.:..:||:|:||:|:|....:|.|:.||:.||.|:.||:|.||....||   ..|:|..
 Frog   246 APDVVDGTCVAVNNKYRLMAFGCVGGSVLVFTIDNTTGALQLSHKLELTPKQYPDMWNKTGAVKL 310

  Fly   320 LKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFM 384
            ::||||..|:.|:|..|||||||.|||.|:.||..||....|...:..|:|..:.|.||||.|:.
 Frog   311 IRWSPDCSVVMVTWECGGLSLWSVFGAHLICTLGGDFDYRADGTKKEALRICSMSWGTEGYHLWA 375

  Fly   385 LKLHPEKD------------KSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLNQGNNLELT 437
            :.....::            :|.:||.||:||||::||||:....:||||:|.||||.|:..:..
 Frog   376 ITADSSQNTGYEMSDKSVPQQSGILQFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGDATQTQ 440

  Fly   438 YA--GS----------HGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNY 490
            .|  ||          ...||.|        ||:...|         |.|...::|.|:|:...|
 Frog   441 NARNGSSQSEHKPLRDRSPFPGS--------SGNSQGL---------STLLGHRHWHVVQIQSTY 488

  Fly   491 AATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMG 555
            ..:||||||.|||..|.::||.|:.|.|||||:|::||||||.:||::.||||||.||..|:|:.
 Frog   489 LQSNWPIRYTAIDKVGQNVAVVGKFGFAHYSLLTKKWKLFGNITQEQNMVVSGGLSWWKEFIVLA 553

  Fly   556 CYSLLDRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSK----- 615
            |::|.::.:|||.|.....|||.:.|.::|:...:.|:.||..:|:..||..:.|:::.:
 Frog   554 CFNLSEQQEELRVYLRTSNLDNAFAHVIKVQLETLLLSIFRDMVIIFRADCSICLYSIERKKEGP 618

  Fly   616 NSAYALDIECAYELDVKSICIHPACIVSLTVTNLKNE----LK-PQGQLGGDQAETIIVNVCGRI 675
            |.:..|.:  ..|:.:.....||:.:||:|:|:::.|    || ||...   .||:|::|:.|::
 Frog   619 NPSVCLQV--LQEVSMSRYIPHPSLVVSVTLTSVRTETGISLKMPQQAC---DAESILLNLAGQL 678

  Fly   676 LMIQRD-AGEQV--------PNTLLATC----LASCVEVFWLS--------HSLERCAMRDCLWL 719
            :|:||| :|.|:        .:.||..|    ||..||..|.:        |.||      .|||
 Frog   679 IMLQRDRSGPQIREKDAKTHQHKLLPFCAPVVLAQSVENVWSTCRANKQKRHLLE------ALWL 737

  Fly   720 YSGAHGMRVWLPILPPGRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENE 784
            ..|..||:||||:.|  |:.|        :.|||:||||||.|.:.:|||.|||::.:|||..||
 Frog   738 SCGGAGMKVWLPLFP--RDHR--------KPHSFLSKRIMLPFHINIYPLAVLFEDALVLGAINE 792

  Fly   785 STLY--------ANEQVS-HFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYF 840
            :..|        ::|.:. ||  ||.::||.||||||.:||||:.||||..|..:||||.:||||
 Frog   793 TVAYDCLNNLSTSSEHLEVHF--PFCIVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYF 855

  Fly   841 PHALELLLHEVLEEEATSKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGK 905
            ||.|||:|||||||||||::||||..||::..||.|||::|:|:|.||||||.|||.|||:..|.
 Frog   856 PHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGN 920

  Fly   906 PKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDP 970
            |||||:.||.::.|:|||||||||||:|.:.||:|:||:|.:.||:|.||:|.:.:|||||||..
 Frog   921 PKDLFEECLMAQDLETAASYLIILQNMEAAAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGS 985

  Fly   971 NEIDSPRSSMVVNVKIAPPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTS-NLPKDK---Q 1031
            .|:::            ||....||:..:.....|       .|.||.|.:.:: |.|..|   |
 Frog   986 GEMET------------PPATPTTQEPSSTGGFEF-------FRHRSISLSQSAENFPSGKFNLQ 1031

  Fly  1032 ASGTPGVAPVTESSSAGAPSVVRRRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFH 1096
            .         |.|..:||......:.:...|...||::|.||||:||:..:|.|||...|.|.|.
 Frog  1032 K---------THSMPSGAAGKRWSKDSDCAENMYIDMMLWRHARRLLEEIRLKDLGGFAAQLGFE 1087

  Fly  1097 LVSWLSQESERAAKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTGGGGSSQTSES- 1160
            |:.||.:|..|||:::||..:|:.||::...|.|....|..:.....|..| |..|.....|:|
 Frog  1088 LIGWLCKERTRAARVEDFVTSLKKLHKDFLWPFPVIPVASINSPFKNGKFR-TAVGEQFLKSQSA 1151

  Fly  1161 -GYFSL--ATPNGAATQSPQLQPSIREEEEELQQPSS----------LPILK------------- 1199
             |:.::  .||..:|.:|.....|:...:.|:...||          .|::.
 Frog  1152 DGFLNMDVETPIPSAVRSHSWMGSLGTSQREMDSTSSHSPHTQDAFLSPLMNKADECSIGSATDL 1216

  Fly  1200 TRSGSQLSFD------NFRYRRLYSLPTSE-DDLAVDIL---PQKLSIKLRYLLQLFIEANCTDY 1254
            |.:.|.:..|      ||   ...||..|| :.:::::.   |.|..::|||||.:|:||.|.::
 Frog  1217 TETSSMVDGDWTMVDENF---STLSLTQSELEHISMELANKGPHKSQVQLRYLLHVFMEAGCLEW 1278

  Fly  1255 ALVLSILLQDAASISRIVNGIIRSESVHTCRRTESALKQLSQS---------TFEHSGSLYRGFV 1310
            .:::.::|::::.|::::|       :..|......:.|..||         |.:..|  |:.|:
 Frog  1279 CVIIGLILRESSVINQVIN-------LLQCPEVAEEMLQGIQSGLQAVDVWATTDCPG--YKPFL 1334

  Fly  1311 LTLQPHVYLLEQYIQSLGDAPCSQLQDAGPGTEQGVDVSTGLQGLQNEVGEFVPN-----SQQAN 1370
            ..::|               |..:|.            :|.::.:|.|.  |.|.     ::|:
 Frog  1335 NIIRP---------------PLQKLS------------ATTVEQVQTEA--FQPTIPIKFTEQS- 1369

  Fly  1371 GNQWTVADLNP--NHQRLTRHASLESNGNAVVASGSSAHSTPTQRQLSRQNSRE 1422
                     :|  ...|::...|:....:....|| |.|.....||...:.|:|
 Frog  1370 ---------SPCIEESRISTSHSISPQSDTSSVSG-SRHEEDFSRQEKDETSQE 1413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rich	NP_001262205.1	WD40 repeat	265..312	CDD:293791	19/46 (41%)
		RIC1	713..974	CDD:284476	148/269 (55%)
ric1	XP_004910849.1	RIC1	731..988	CDD:369192	149/274 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	394	1.000	Domainoid score	I768
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13806
Inparanoid	1	1.050	756	1.000	Inparanoid score	I554
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261419at2759
OrthoFinder	1	1.000	-	-		FOG0003567
OrthoInspector	1	1.000	-	-		oto103055
Panther	1	1.100	-	-	LDO	PTHR22746
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2750
SonicParanoid	1	1.000	-	-		X3432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190