DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment olf413 and Moxd2

DIOPT Version :9

Sequence 1:	NP_001262204.1	Gene:	olf413 / 40453	FlyBaseID:	FBgn0037153	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001102699.1	Gene:	Moxd2 / 500092	RGDID:	1564286	Length:	619	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	165/563 - (29%)
Similarity:	251/563 - (44%)	Gaps:	76/563 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FNLFLLLLLLA--SGVRAASKLATRSNKTSGSSTASGVGAGTAATSAAAAAASGTPIWDHAIDLN 116
            |.||||.:|.|  .|.|.:.....|.::....|                          ||:.|.
  Rat     7 FRLFLLWVLAAFSQGKRLSPTSPLRYSRFLDPS--------------------------HAVFLR 45

  Fly   117 DDFRILWQIINQDITFEIQARTLGYVGFGFSPDGNLAGADMAIGWV-DKGQTYFQDRHVTRNGDP 180
            .||....:|    ||||:|.:|.|:||.|.:......|:|:.:|.| ..|..||.|:|:......
  Rat    46 WDFDYETEI----ITFELQVQTTGWVGLGITDRYTFVGSDLVVGGVLPNGNVYFSDQHLLDEDTL 106

  Fly   181 EPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPG 245
            |.  |.|||..|:...|::..|.:||.|...:||| ||..||:||||:|..|...|.|.
  Rat   107 EQ--DGSQDAELLKLTEDSVSTTMRFSRPFRSCDP-HDHDITSDTMRVLAAYGLDDIPK------ 162

  Fly   246 TLPDPARAFRPYRPMVLMQRAQLPMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDIN 310
              .:..|.|  .:.:.|:|..|........|..:..|::.|  ..:|..| ..:.|....|..::
  Rat   163 --MNRERTF--VKSIFLLQILQYDDEDAPEDTVIYDLKISN--FLIPEED-TTYACTFLPLPIVS 220

  Fly   311 RKHHLIRYEPIY--DSSSSVHYLQHITLHECQGAHAELEEMAREQGRPCLGARSIPLACNAIVAS 373
            :|||:.::|||.  .:.:.||   |:.::.| |..:.|.....|    |.||......|:.::|.
  Rat   221 KKHHIYKFEPILVERNETMVH---HVLVYAC-GNSSVLPTGIGE----CYGADPAFSLCSHVIAG 277

  Fly   374 WSRGSEGFTYPHEAGYPIESR-QAKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPN 437
            |:.|...:.:|.:.|..|.:. ..::..:|.||:|    |..|..  :.|.||:::|:|..||..
  Rat   278 WAVGGLSYQFPDDVGISIGTPFDPQWIRLEIHYSN----FQNLPG--IRDTSGMRLYYTSHLRKY 336

  Fly   438 DAGTLSIGMDPNWRHIIPPGQKRVVSEGQC----IEDCTGYAFPQQGINIFAVMMRTHQIGKEVK 498
            |.|.|.:|:.....|.||||.:..:|.|.|    .|:..|  .|...|.:.|.::.||..|:.::
  Rat   337 DMGVLQLGISVFPIHFIPPGAEAFLSYGLCKTDKFEEMNG--APVADIYVSACLLHTHLAGRSLQ 399

  Fly   499 LRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEE 563
            ..|.|...:|..:..|.:.|...|:.|.||..|...|||.|:.||.|.:..|..:|.||.:...|
  Rat   400 ALQYRNGTQLQIVCKDFSYDFNLQESRDLPHPVVIKPGDELLIECHYQTLDRDFMTFGGASTINE 464

  Fly   564 SCTVLTLYYPRQKKLTTCHSLPSLPTVLHSLGIEQLATDSNPV 606
            .|.:...|||| ..:::|...|.:..|.:.||.|   ...||:
  Rat   465 MCLIFFFYYPR-INISSCMGYPDIIYVTNELGEE---ASENPM 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf413	NP_001262204.1	DOMON_DOH	111..243	CDD:187689	51/132 (39%)
		Cu2_monooxygen	282..407	CDD:279429	32/127 (25%)
		Cu2_monoox_C	438..583	CDD:281675	48/148 (32%)
Moxd2	NP_001102699.1	DOMON_DOH	36..159	CDD:187689	50/155 (32%)
		Cu2_monooxygen	193..317	CDD:395859	34/138 (25%)
		Cu2_monoox_C	336..482	CDD:397669	47/148 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59784
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45605
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10157
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860