DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment olf413 and MOXD1

DIOPT Version :9

Sequence 1:	NP_001262204.1	Gene:	olf413 / 40453	FlyBaseID:	FBgn0037153	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_056344.2	Gene:	MOXD1 / 26002	HGNCID:	21063	Length:	613	Species:	Homo sapiens

Alignment Length:	691	Identity:	215/691 - (31%)
Similarity:	323/691 - (46%)	Gaps:	122/691 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GVGAGTAATSAAAAAASGTPIWDHAIDLNDDFRILWQIINQDITFEIQARTLGYVGFGFSPDGNL 152
            |:..||||..:.......|     .:|....:.:.|......|.|.:|.||.|||||||||.|.:
Human    11 GLLPGTAAGGSGRTYPHRT-----LLDSEGKYWLGWSQRGSQIAFRLQVRTAGYVGFGFSPTGAM 70

  Fly   153 AGADMAIGWVDKGQTYFQDRHVTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSH 217
            |.||:.:|.|..|:.|.||...  |.:.|...|..|||.|....||:|||::.|.|:|.||| .:
Human    71 ASADIVVGGVAHGRPYLQDYFT--NANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHTCD-IN 132

  Fly   218 DIAITNDTMRLLYMYHAQD-----PPHGSVRPGTLPDPARAFRPYRPMVLMQRAQLPMPSPTHDE 277
            |.:||:.|:|:::.||.:|     |.:.....||  ...|...|.:..||  ...||
Human   133 DKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGT--KSLRLLNPEKTSVL--STALP-------- 185

  Fly   278 RVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKHHLIRYEPIYD--SSSSVHYLQHITLHECQ 340
               ..:|.|:||.:|..| ..:||:|||:.....|||:|:.||:..  ..|.||   ||.|::|.
Human   186 ---YFDLVNQDVPIPNKD-TTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVH---HILLYQCS 243

  Fly   341 GAHAELEEMAREQGRPCLGARSIP---LACNAIVASWSRGSEGFTYPHEAGY----PIESRQAKY 398
            .   ...:...|.|..|... ::|   |.|..::.:|:.|.|||:||...|.    |::..   |
Human   244 N---NFNDSVLESGHECYHP-NMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPH---Y 301

  Fly   399 YLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHIIPPGQKRVVS 463
            .|:|.||:|  |.:.:    .:.|||||::::|..:|..|||.:..|:..:..|.||||.....|
Human   302 VLLEVHYDN--PTYEE----GLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQS 360

  Fly   464 EGQCIEDCTGYAFPQQ---GINIFAVMMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDVAYQDFR 525
            ||.|..:|...|...:   ||::|||::..|..|:.::||..|:.:|:..:|:|.:.|..:|:|:
Human   361 EGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQ 425

  Fly   526 RLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEESCTVLTLYYPRQKKLTTCHSLPSLPTV 590
            .|.:....:|||.||.||.|::..|..:|.|||:.:.|.|....||||| ..||.|.|:|.:...
Human   426 YLKEEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPR-INLTRCASIPDIMEQ 489

  Fly   591 LHSLGIEQL--ATDSNPVLISSPPELAGMTLEARLISYDWENQFGEFQEATRKGSFKPICWGAKN 653
            |..:|::::  ...:.|.:|.||.:...::                |.:|..|  ||   |..|
Human   490 LQFIGVKEIYRPVTTWPFIIKSPKQYKNLS----------------FMDAMNK--FK---WTKK- 532

  Fly   654 HVVPGSEFLEGYSIN-VTKTYKKHRRCKPKRPLAPPTER--------TAPPPASDLSELPVLHEL 709
                     ||.|.| :..:...:.||.       .|:.        ||.||  |: |.|...|
Human   533 ---------EGLSFNKLVLSLPVNVRCS-------KTDNAEWSIQGMTALPP--DI-ERPYKAE- 577

  Fly   710 DNNNIIEGAARSSRSSATDVHSLSRGSGRHFISCLLWLGAS 750
               .::.|.:.||        ||.|....:.:.|||.|..:
Human   578 ---PLVCGTSSSS--------SLHRDFSINLLVCLLLLSCT 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf413	NP_001262204.1	DOMON_DOH	111..243	CDD:187689	53/136 (39%)
		Cu2_monooxygen	282..407	CDD:279429	44/133 (33%)
		Cu2_monoox_C	438..583	CDD:281675	55/147 (37%)
MOXD1	NP_056344.2	DOMON_DOH	29..165	CDD:187689	54/143 (38%)
		Cu2_monooxygen	186..312	CDD:279429	45/138 (33%)
		Cu2_monoox_C	335..482	CDD:281675	55/147 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156398
Domainoid	1	1.000	95	1.000	Domainoid score	I7447
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22904
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5865
OMA	1	1.010	-	-		QHG59784
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0002519
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101678
Panther	1	1.100	-	-	LDO	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4667
SonicParanoid	1	1.000	-	-		X2216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700