DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment olf413 and Dbh

DIOPT Version :9

Sequence 1:	NP_001262204.1	Gene:	olf413 / 40453	FlyBaseID:	FBgn0037153	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_037290.3	Gene:	Dbh / 25699	RGDID:	2489	Length:	621	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	151/525 - (28%)
Similarity:	245/525 - (46%)	Gaps:	59/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 IDLNDDFRILWQI-INQDI---TFEIQARTLGYVGFGFSPDGNLAGADMAIGWVDKGQTYFQDRH 173
            :|......:.|.: .:|:|   ..::|....| |.||.|..|.:..||:.:.|.|..:|||.|..
  Rat    56 LDPEGTLELSWNVSYDQEIIHFQLQVQGPRAG-VLFGMSDRGEMENADLVMLWTDGDRTYFADAW 119

  Fly   174 VTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPP 238
            ..:.|...  :|..|||.|:.....:....|.|:|...||||. |..|.:||:.|:|
  Rat   120 SDQKGQIH--LDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPK-DYVIEDDTVHLVY-------- 173

  Fly   239 HGSVRPGTLPDPARAFRPYRPMVL---MQRAQLPMP---SPTHDERVRVLELRNEDVELPAGDLP 297
                  |.|.:|.::........|   :|:.||..|   :|.....|:.:::|..||.:|:.: .
  Rat   174 ------GILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTE-T 231

  Fly   298 LFWCKMFKLEDINRKHHLIRYEPIYDSSSS--VHYLQHITLHECQGAHAELEEMAREQGRPCLGA 360
            .:||.:.:|.....:||:|.||.|....:.  ||   |:.:.:|..   |.|......| || .:
  Rat   232 TYWCYITELPLHFPRHHIIMYEAIVTEGNEALVH---HMEVFQCTN---ESEAFPMFNG-PC-DS 288

  Fly   361 RSIP---LACNAIVASWSRGSEGFTYPHEAGYPI-ESRQAKYYLMETHYNNLKPDFAQLHARQMA 421
            :..|   ..|..::|:|:.|::.|.||.|||.|. .|..:::..:|.||:|.:    .:..|:
  Rat   289 KMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPFGGSGSSRFLRLEVHYHNPR----NIQGRR-- 347

  Fly   422 DNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHIIPPGQKRVVSEGQCIEDCTGYAFPQQGINIFAV 486
            |:||:::::|..||||:||.:.:|:.......|||.:...|..|.|.:.||..|.|:.||.|||.
  Rat   348 DSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFAS 412

  Fly   487 MMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRK 551
            .:.||..|::|.....|..::...:..|::....:|:.|.|..:|....||.||..|.|::.:|.
  Rat   413 QLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRT 477

  Fly   552 AITLGGLTMKEESCTVLTLYYPRQKKLTTCHS------LPSLPTVLHSLGIEQLAT---DSNPVL 607
            ..|:||..:.||.|.....|||: .:|..|.|      |.....:::..|.|::.|   .|.|..
  Rat   478 MATVGGFGILEEMCVNYVHYYPK-TELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQ 541

  Fly   608 ISSPP 612
            .:|.|
  Rat   542 FASVP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf413	NP_001262204.1	DOMON_DOH	111..243	CDD:187689	38/133 (29%)
		Cu2_monooxygen	282..407	CDD:279429	38/130 (29%)
		Cu2_monoox_C	438..583	CDD:281675	46/144 (32%)
Dbh	NP_037290.3	DOMON	60..175	CDD:397434	37/132 (28%)
		Cu2_monooxygen	217..340	CDD:395859	38/131 (29%)
		Cu2_monoox_C	363..519	CDD:397669	49/156 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820