DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment olf413 and DBH

DIOPT Version :9

Sequence 1:	NP_001262204.1	Gene:	olf413 / 40453	FlyBaseID:	FBgn0037153	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_000778.3	Gene:	DBH / 1621	HGNCID:	2689	Length:	617	Species:	Homo sapiens

Alignment Length:	519	Identity:	151/519 - (29%)
Similarity:	236/519 - (45%)	Gaps:	55/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 STASGVGAGTAATSAAAAAASGTPIWDH-AIDLNDDFRILWQI--INQDITFEIQARTL-GYVGF 144
            |||..:.......:...:|...:|:..| .:|......:.|.:  ..:.|.|::..|.| ..|.|
Human    23 STAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLF 87

  Fly   145 GFSPDGNLAGADMAIGWVDKGQTYFQDRHVTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRK 209
            |.|..|.|..||:.:.|.|....||.|....:.|...  :||.|||.|:..........|.|:|.
Human    88 GMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIH--LDPQQDYQLLQVQRTPEGLTLLFKRP 150

  Fly   210 LDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPGTLPDPARAFRPYRPMVL---MQRAQL--- 268
            ..||||. |..|.:.|:.|:|              |.|.:|.|:........|   :||.||
Human   151 FGTCDPK-DYLIEDGTVHLVY--------------GILEEPFRSLEAINGSGLQMGLQRVQLLKP 200

  Fly   269 PMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKHHLIRYEPIYDSSSS--VHYL 331
            .:|.|........:|::..::::|:.: ..:||.:.:|.....:||:|:||||....:.  ||
Human   201 NIPEPELPSDACTMEVQAPNIQIPSQE-TTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVH-- 262

  Fly   332 QHITLHECQGAHAELEEMAREQGRPCLGARSIP---LACNAIVASWSRGSEGFTYPHEAGY---- 389
             |:.:.:|.   .|::.:....| || .::..|   ..|..::|:|:.|::.|.||.|||.
Human   263 -HMEVFQCA---PEMDSVPHFSG-PC-DSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGG 321

  Fly   390 PIESRQAKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHII 454
            |..||   |..:|.||:|      .|......|:||:::|:|..||..:||.:.:|:.......|
Human   322 PGSSR---YLRLEVHYHN------PLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAI 377

  Fly   455 PPGQKRVVSEGQCIEDCTGYAFPQQGINIFAVMMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDV 519
            ||.:...:..|.|.:.||..|.|..||:|||..:.||..|::|....:|...|...:..|::...
Human   378 PPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSP 442

  Fly   520 AYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEESCTVLTLYYPRQKKLTTCHS 583
            .:|:.|.|.:.|...|||.||..|.|::..|:..|:||..:.||.|.....||| |.:|..|.|
Human   443 HFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYP-QTQLELCKS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf413	NP_001262204.1	DOMON_DOH	111..243	CDD:187689	39/135 (29%)
		Cu2_monooxygen	282..407	CDD:279429	38/133 (29%)
		Cu2_monoox_C	438..583	CDD:281675	48/144 (33%)
DBH	NP_000778.3	DOMON	57..172	CDD:281361	37/131 (28%)
		Cu2_monooxygen	213..337	CDD:279429	39/141 (28%)
		Cu2_monoox_C	362..516	CDD:281675	49/145 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820