DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LSAMP and Ama

DIOPT Version :9

Sequence 1:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens
Sequence 2:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	99/336 - (29%)
Similarity:	151/336 - (44%)	Gaps:	35/336 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     6 QPDRKQLPLVLLRLLCLLPT-----GLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNS-KVAW 64
            :||..:|.|::..:.||..:     ..||    .::.:.::....||:....|.||:... .|:|
  Fly     6 RPDMARLRLLIGLIFCLAISLDSVLSAPV----ISQISKDVVASVGDSVEFNCTVEEVGQLSVSW 66

Human    65 LNR------SGIIFAGHDKWSL-DPR-----VELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQH 117
            ..|      :.::.:..:..|| |.|     .|..|..|..|:.|||.::|.|.|.|.|.|....
  Fly    67 AKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSA 131

Human   118 EPK-TSQVYLIVQVPPKIS-NISSDVTVNEGSNVTLVCMANGRPEPVITWRH----LTPTGREFE 176
            ..| |.::.|.::.||.|: |......|.||.|:.|.|.|||.|:|.|:|..    :.|.|....
  Fly   132 TEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLL 196

Human   177 GEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEA-TTGRQASLKCE 240
            .|.. |.|..:.|...|.|.|.|.|.....|.:.::|.|.:.|.|...:...| .....|.|:|.
  Fly   197 AEPT-LRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECS 260

Human   241 ASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLT-----VTNVTEEHYGNYTCVAANKLGVTN 300
            ....|||...|:::...:.|:...|:.:|...|..|     :.:|.||.:|:|.|.|.||||..:
  Fly   261 VQGYPAPTVVWHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHAD 325

Human   301 ASLVLFKRVLP 311
            |.|.||:.|:|
  Fly   326 ARLHLFQTVIP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	28/103 (27%)
		Ig	132..215	CDD:386229	29/87 (33%)
		Ig_3	219..294	CDD:372822	22/80 (28%)
Ama	NP_731114.2	I-set	33..143	CDD:254352	30/113 (27%)
		Ig	37..127	CDD:299845	24/89 (27%)
		IG_like	154..234	CDD:214653	26/80 (33%)
		IGc2	161..223	CDD:197706	23/62 (37%)
		I-set	254..330	CDD:254352	25/75 (33%)
		IGc2	254..322	CDD:197706	21/67 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42757
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880