DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LSAMP and DIP-theta

DIOPT Version :9

Sequence 1:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	101/340 - (29%)
Similarity:	157/340 - (46%)	Gaps:	46/340 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    34 FNRGTDNITVRQGDTAILRCVVED-KNSKVAWLN---------RSGIIFAGHDKWSLDPRVELEK 88
            |.....|:||.....|:|:|||:: :..|:|||.         ::.:|...|       |:.:..
  Fly   132 FGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNH-------RMSITH 189

Human    89 RHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQV-YLIVQVPPKISN--ISSDVTVNEGSNVT 150
            .....:.|||:.|...|:|.|.|.:.|  :|..||| ||.|.|||.|.:  .|:|:.:.||||||
  Fly   190 AEKRAWILRIRDVKESDKGWYMCQINT--DPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVT 252

Human   151 LVCMANGRPEPVITWRH------LTPTGRE---FEGEEEYLEILGITREQSGKYECKAANEVSSA 206
            |.|.|.|.|.|.||||.      ..|.|.|   :.|  .:|.|..:.|...|.|.|.|:|.:...
  Fly   253 LKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNG--SFLTIAKVNRLNMGAYLCIASNGIPPT 315

Human   207 DVKQVKVTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTE 270
            ..|:|.:.|::||.| .:::...|...:..:|:|::.|.|.....|.::||.|........::.|
  Fly   316 VSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFE 380

Human   271 G----QSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF--------KRVLPTIPHPIQEIGTT 323
            .    ...||:..|..:.:|.|.|||.|.||.|:.::.|:        ..:.||:......:...
  Fly   381 SGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLV 445

Human   324 VHFKQKGPGSVRGIN 338
            .:.|::..||.:..|
  Fly   446 KYNKEQRYGSSQNSN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	30/100 (30%)
		Ig	132..215	CDD:386229	34/93 (37%)
		Ig_3	219..294	CDD:372822	20/79 (25%)
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	31/101 (31%)
		IG_like	137..230	CDD:214653	31/101 (31%)
		IG_like	240..324	CDD:214653	32/85 (38%)
		IGc2	247..310	CDD:197706	27/64 (42%)
		Ig	327..419	CDD:299845	25/91 (27%)
		IG_like	343..420	CDD:214653	21/76 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10656
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.900