DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7133 and DNAJC8

DIOPT Version :9

Sequence 1:	NP_649379.1	Gene:	CG7133 / 40449	FlyBaseID:	FBgn0037150	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_055095.2	Gene:	DNAJC8 / 22826	HGNCID:	15470	Length:	253	Species:	Homo sapiens

Alignment Length:	113	Identity:	34/113 - (30%)
Similarity:	58/113 - (51%)	Gaps:	24/113 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YQVLGLPRNATDSEIKDAFRRLSLQYHPDKNEDGA----KEFLRINEAHRVLIDHQRRALYDCCF 69
            ::||.:....||.|||..||:||:..|||||:|.|    |.|..:::|:::|:|.:::.
Human    59 FEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKK------ 117

  Fly    70 QSMDVEAIIPA---------ENANGQLPELGNPFFPMPPETPPASFRE 108
            :::||   |.|         :....||.:.|.|  .:..|..|..|::
Human   118 RALDV---IQAGKEYVEHTVKERKKQLKKEGKP--TIVEEDDPELFKQ 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7133	NP_649379.1	DnaJ	7..66	CDD:278647	23/60 (38%)
CG7133	NP_649379.1	DnaJ	7..>66	CDD:223560	23/60 (38%)
DNAJC8	NP_055095.2	CbpA	51..>238	CDD:225124	34/113 (30%)
		DnaJ	57..112	CDD:99751	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..253
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	189..192
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:27133716	203..206
		Essential for polyglutamine aggregation suppression. /evidence=ECO:0000269\|PubMed:27133716	232..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910