DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7139 and CUE2

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_012833.1	Gene:	CUE2 / 853772	SGDID:	S000001573	Length:	443	Species:	Saccharomyces cerevisiae

Alignment Length:	409	Identity:	75/409 - (18%)
Similarity:	140/409 - (34%)	Gaps:	137/409 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 DCSESPSNVAELLDM--ELAWSIYNSEQLAAKKAAELTARKQTPTDIATHLTKMKLCET------ 705
            |.|...:.:.:|.||  :|..|:...:.:..:|:.|     .|.:|:..:.|..||.:.
Yeast    52 DKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVE-----STISDLLNYETLQKLKDNQANSPD 111

  Fly   706 -----------------------FPDVPTDTVLEVFAATGSNYVQTVEVLDSNVKSMLSKAELYD 747
                                   |.|.|.:...|..|..|.:.|:.:      :|.:|   :.||
Yeast   112 SVKRNEKKNNWESTNDHIESIIKFTDAPKNIAQEYLAENGFDTVKAI------IKIIL---DYYD 167

  Fly   748 KALREGEKLSEQMALEERRQQQQQKQHNSSGQGQRSSSS-------------------------S 787
            |  |:.:|..:...:        ::..|::.:|.|..||                         |
Yeast   168 K--RDFKKDVDTFKV--------KRSPNTTVRGGRVQSSTGLAHVLKKGKESANVAQESLKRPRS 222

  Fly   788 YA-SGRSPQLQEEVKCAALRDFEETRNMAAHHSQLKAEC----------YLKAKQAVQRGNSSV- 840
            |. |..|||:.|..:..|     :.|::.|.:.:...:|          .|.....:...:.::
Yeast   223 YKHSLDSPQMVELNELVA-----DNRDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDDKNIT 282

  Fly   841 ---------ALYYSEIAKLHKQKIDVFNQRAANCIMEVHR---HTQNNPD-------------LL 880
                     .|...:..|.|..|.........|.:...::   |.:..|:             .|
Yeast   283 KTWNFDEGFTLTSRDNCKQHLPKFSTPQISRRNEVGNTYKLPLHDKETPEGAVPVINNLFQTYRL 347

  Fly   881 DLHYLHTVEAISCLDLFLDR--------------HITVLRNTTRVYKHVFIITGRGLHSANGVST 931
            |.|.....||:|.|.|.|::              :|....:..:....:.::||||:||..|:|.
Yeast   348 DFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGRGIHSIGGISK 412

  Fly   932 IKNRVKARLGERR-LRWQE 949
            ::.:||:.|.:.. :.|:|
Yeast   413 VRLQVKSFLEKNHYIFWEE 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627
		AAA_33	105..245	CDD:290396
		GluZincin	606..>707	CDD:301352	14/88 (16%)
		DUF1771	812..868	CDD:285756	9/75 (12%)
		SMR	877..960	CDD:214676	24/101 (24%)
CUE2	NP_012833.1	CUE1_Cue2p_like	10..51	CDD:270557
		CUE2_Cue2p_like	57..94	CDD:270558	9/41 (22%)
		SMR	344..440	CDD:214676	23/88 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46535
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000