DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7139 and n4bp2

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_001073436.1	Gene:	n4bp2 / 558048	ZFINID:	ZDB-GENE-061103-451	Length:	1692	Species:	Danio rerio

Alignment Length:	1369	Identity:	259/1369 - (18%)
Similarity:	421/1369 - (30%)	Gaps:	572/1369 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 KLMIIMRGPSGSGKSTLAESLLRQAHLLDRHQVRDFVLSSDDYFKTRRGYVFNPTLLPAAHEWNQ 167
            ::::::||..||||:|||.::|.|       .....|||:|:||.....|.|.|.||..|||||.
Zfish   379 QVLVLLRGAPGSGKTTLANAMLAQ-------NPGGVVLSTDEYFMRNGHYYFEPNLLGEAHEWNH 436

  Fly   168 QRVRDKAASGWSPIIVDNTNTMVWEMQPYVQFAVRHGYVIELLEPNTSWCKSASKLAQKNVHNVP 232
            ||.:|....|.||||:|||||..|||:|||..|.:|.|.:...||:|.|.....:|.::..|.|.
Zfish   437 QRAKDAFEKGRSPIIIDNTNTQCWEMKPYVAMAQKHRYKVLFREPDTWWKTKPRELEKRTRHQVT 501

  Fly   233 RENIQRMLERFER---------------------------------------------------- 245
            :|.|:|||||::|
Zfish   502 KEKIRRMLERYDRFVSVQTIMNSNKPEPVPSVAALTQIETEQPQQFLHPGLTHPDLVGDSDLSKL 566

  Fly   246 --------------------TTAGE---------------------------------------- 250
                                |:|||
Zfish   567 NLHLSSSLPDVSSVSQIYNTTSAGEEESEMALYTCKESMLTCENVQEDARTPQSDLLDSEGLDSE 631

  Fly   251 ----LIQLMKE---------TKYSVELPQLRNHPPL-------------------PAV------- 276
                |:...||         .:|.|...:..:.||:                   |.|
Zfish   632 LDACLVDTDKEFSNLRSGINEEYIVSEHETFHEPPVAFSESIAQRIRKVRENDRKPQVKSVIDQP 696

  Fly   277 ----PIITS-------------FEESKL------------------------------------L 288
                ||:.|             |.|.|:                                    |
Zfish   697 VNLDPILDSSEPKKEKRCEGEPFVEDKVVRPELLDFVGDWPLVSQDQRQGRCQNSRNNIFNNSGL 761

  Fly   289 EAPVPAPAENAFK------------LNANAQTWVPYEHGA-----PSYW----SQTVNSV----- 327
            ||.|....:|..|            ..|..|..|....|.     |.::    |.|:.::
Zfish   762 EASVVEHQDNKDKDKDGQDKDVSTDSTAEFQKLVDLLQGGGRNSFPDFYHTPASNTLTTLQSSLL 826

  Fly   328 -------DTGDATVPEIPDA-----------------------------LGAAAPVKSELSIIDL 356
                   |.....:||:||.                             :|.:..:.||.|..|.
Zfish   827 SVKESDRDLEPMVLPELPDCVLERKYSEGTNPRKDYIYSPSTPEQGADPIGPSNQMSSEKSTQDE 891

  Fly   357 LREE-------------------------------------NQ-----------IKVVPSKAESS 373
            :.:|                                     ||           :..:||:...:
Zfish   892 IEQEDNGKGSKVVIDSEGSLERRKGLSRRSGKSCKLALTFTNQSTSSPCSQSPVVSHLPSEITPA 956

  Fly   374 GAKP-LEM--HSLDCPNEPKGFAHLRQMYPNKQ-------------------------------- 403
            |..| |.|  .|......|:.||.|.::...|.
Zfish   957 GGTPSLPMLCSSTSAQTYPQDFALLWRIDQQKSFELASDSSNSRMFVLEGNSLRFTPKINEEESA 1021

  Fly   404 ----------------------------------LAG---------LWDLFVKCQADVDWAVDIL 425
                                              |:|         |.||:.||..|::|..::|
Zfish  1022 WQHRVPYRVVHEKGSQVEDNDFRESNSKQQNLEILSGHFRHVSVDILEDLYEKCHQDIEWTTNLL 1086

  Fly   426 L-------KEDELNAATGSDQIGFEETIDSEEAAQFQCDCDKAVEAQESPISTPICASPTLPVSK 483
            |       |||        :::.....:..:|:.:......:.|...:|..:..:.:..:...|.
Zfish  1087 LDSGERLYKED--------NEVDLGSLVPMQESCELSIKPTETVVCSQSDQARALLSDDSSNSSL 1143

  Fly   484 TESKPQRQPRNKRASAP-----------------------------------TNKELQ--LKIQN 511
            :...|:.|..|....:|                                   |.|:|:  .|||.
Zfish  1144 SSISPKSQETNPSEVSPASDDWSPGQSSLSDAEGYDEESMTEEICESEPSHETVKQLKEDTKIQL 1208

  Fly   512 CFVLGDEQYSEHT-RKIRDIRNGILDQ-PTVPKLLE-----------APEE-------------- 549
            ......|:.:|.| .:...:::.::.| ..:.:|||           ..||
Zfish  1209 AVPAIKEELAEKTGEQDAGLQDTLVSQSEQIVRLLEEDLKEWKEEEGGGEEREDDETKAEVNALT 1273

  Fly   550 -------PELEEQEEEEDPE-ENTLLEIDLGGTLIEQLRAQFHTEDELLPPEQELPTATKIFMP- 605
                   .|:|::||||..| ||......||..  ||......:.:..||.|..| ..|::|.|
Zfish  1274 QLLLSQVDEMEQKEEEERKERENERRRTGLGKR--EQSSMDIQSLELKLPTELAL-QLTELFGPV 1335

  Fly   606 -----------------RQLAKQLYMLWMEAV----------FNQLEEIRQQ-----TMRDDEQF 638
                             ..|||.|:..|.|.:          :..::|...|     .:||....
Zfish  1336 GISPGAFSSDDCAVQIDLNLAKLLHQKWKETIQEKHRLAALSYQLMQECPTQWGSKSKLRDQTAL 1400

  Fly   639 ARLLKHPGYADCSESPSNVAELLDMELAWSIYNSEQLAAKKAAELTARKQTPTDIATHLTKMKLC 703
            ...:....:.:.|.:|.::.:::..|..  :.:|.:.......:|..:     |.|..|.:.:|.
Zfish  1401 HEEIPFMDHWNASCAPVSLRDIMIEEQV--MQDSVEKCRSSRKDLDKK-----DSAAKLKENQLF 1458

  Fly   704 ETFPDVPTDTVLEVFAATGSNYVQTVEVL-----DSNVKSMLSKAELYDKALREGEKLSEQMALE 763
            ..||.:....:.::|.....:..||.:.|     |..||::::            .:.|.|....
Zfish  1459 SMFPTIDRHFLRDIFRDHNYSLEQTEQFLQTLLDDGPVKNVVA------------PEPSPQRNGT 1511

  Fly   764 ERRQQQQQKQHNSSGQGQRSSSSSYASGRSPQLQEEVKCAALRDFEETRNMAAHHSQLKAECYLK 828
            .|...:::|..:..|:   ..::.:.....|            ::::.|..|....:.:.||:.|
Zfish  1512 YRAPSKERKWKSRDGE---VDAAQFQDSEDP------------EYDDFRTEATLQRRQQIECFNK 1561

  Fly   829 AKQAVQRGNSSVALYYSEIAKLHKQKIDVFNQRAANCIMEVHRHTQNNPDLLDLHYLHTVEAIS- 892
            |.:|.::|...||.:|::...:|.:|:...|.|||..|.:....:....::||||.||..|||.
Zfish  1562 AAEAHRQGRKDVASFYAQQGHMHGEKMREANHRAAMQIFQQVNASLLPQNILDLHGLHVDEAIHH 1626

  Fly   893 ----CLDLFLDRHITVLRNTTRVYKHVFIITGRGLHSANGVSTIKNRVKARLGERRLRWQEVNPG 953
                .||..|:.|..|..      ..:.:|||||..|..||:.|:..|...|..:...:.|...|
Zfish  1627 LSQVLLDKCLEFHQGVCP------PQLSVITGRGNRSQGGVARIRPAVLDYLKNQHYSYTEPKIG 1685

  Fly   954 LLRV 957
            |:.|
Zfish  1686 LVLV 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627	77/326 (24%)
		AAA_33	105..245	CDD:290396	63/139 (45%)
		GluZincin	606..>707	CDD:301352	19/115 (17%)
		DUF1771	812..868	CDD:285756	18/55 (33%)
		SMR	877..960	CDD:214676	29/86 (34%)
n4bp2	NP_001073436.1	CUE_N4BP2	61..101	CDD:270548
		AAA_33	381..514	CDD:290396	63/139 (45%)
		NK	381..>510	CDD:302627	60/135 (44%)
		CUE	1453..1487	CDD:270465	6/33 (18%)
		DUF1771	1543..1602	CDD:285756	18/58 (31%)
		SMR	1610..1691	CDD:214676	29/86 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594150
Domainoid	1	1.000	131	1.000	Domainoid score	I5124
eggNOG	1	0.900	-	-		E1_KOG2401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3904
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48413at33208
OrthoFinder	1	1.000	-	-		FOG0001378
OrthoInspector	1	1.000	-	-		otm25054
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46535
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.860