DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7139 and N4bp2

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_006504066.1	Gene:	N4bp2 / 333789	MGIID:	2684414	Length:	1785	Species:	Mus musculus

Alignment Length:	1425	Identity:	272/1425 - (19%)
Similarity:	444/1425 - (31%)	Gaps:	587/1425 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NNNDNNNCGRSKSGGTHRKYATAEAPSS--IRMCPASNLNSNQSNKQFNSICQRAQAGHKLMIIM 108
            ::|......|...|.:  .|...|||:|  :|....|.:.                   .:::::
Mouse   432 SHNSPTKVWRGGEGAS--AYQVQEAPASQPVRKKATSFVG-------------------LVLVLL 475

  Fly   109 RGPSGSGKSTLAESLLRQAHLLDRHQVRDFVLSSDDYFKTRRGYVFNPTLLPAAHEWNQQRVRDK 173
            ||..|||||.||.:       |........:||:||||.....|.|:...|..||||||.|.::.
Mouse   476 RGLPGSGKSFLART-------LQEDNPGGVILSTDDYFYINGQYQFDVKYLGEAHEWNQNRAKEA 533

  Fly   174 AASGWSPIIVDNTNTMVWEMQPYVQFAVRHGYVIELLEPNTSWCKSASKLAQKNVHNVPRENIQR 238
            .....||:|:||||...|||:|||..:.:|.|.:...||:|.|.....:||::|:|.|.:|.|.|
Mouse   534 FEKKVSPVIIDNTNLQAWEMKPYVALSQKHKYKVLFREPDTWWKFKPKELARRNIHGVSKEKISR 598

  Fly   239 MLERFER-----------------------------------------------------TTAGE 250
            |||.::|                                                     .|..:
Mouse   599 MLEHYQRFVSVPIIMSSSDPEKTERIELCAYASDDSPRDSEAISSAKEDSVSSASPKHSELTEEK 663

  Fly   251 LIQLMKETKYSVELPQL------------------------------------------------ 267
            .:::..:...||..|||
Mouse   664 TLEVATQAVLSVRDPQLPCPGLNRGRKELGDVSHGGHNPFFQEAPSTYFPNPESKGQATDRSEEE 728

  Fly   268 ------RNH----------------------------------------PP-------------- 272
                  :.|                                        ||
Mouse   729 QEMVSEKEHCEADAWRPAGGASSDGRCADDNQEACGSAGAAALPGETPSPPEMLEERTAGKKKTI 793

  Fly   273 --------LPAVP--IITSF-----------------------------------EESKLLEAPV 292
                    |..:|  .:::|                                   :..|:|:|.|
Mouse   794 GKQKGKSSLEKIPKQELSNFVGDWPVDKTISQRTKRNRKTEKGLSVQSDKKGNLPQSHKVLDARV 858

  Fly   293 -----------------------------PAPAENAFKLNA-----NAQTWVPYEH--------- 314
                                         |..:.....|:|     ::.:..|.||
Mouse   859 SVNTDPVQPQGSSHGNDDLSEVPSSYHYDPYRSTEQSSLSAVSDWPSSASLAPREHRPRMPKADL 923

  Fly   315 GAPS--------------------YW---------------------SQT--------------- 323
            ..||                    ||                     |||
Mouse   924 SEPSVEFGTNDNLGEIPLYPAHEAYWGTSPEELKTLSSSLRSSEMLPSQTAPEHHPTSLNPLAHS 988

  Fly   324 ----------------------------------VNSVDTGDATVPEIPDALGAAAPVKSELSII 354
                                              |:.||||..|..|..|........|:::::.
Mouse   989 QHALPLTFPSSAAALPGVVGPRSLTEFPVGVSGIVSGVDTGTCTQTEPQDFALLWKIEKNKINVS 1053

  Fly   355 D------------------LLREENQIKVVPSKAESSGAKPLEMHSLDCPNEPKGFAHLRQMYPN 401
            |                  |.|:.|..:.:|.:.....:..:|...|...:|.:....|.:::.:
Mouse  1054 DSVRVLTGRLDGFKPKDFTLNRKVNVQETIPYRVMHDKSTFVEESELTSADESENLNILCKLFGS 1118

  Fly   402 KQLAGLWDLFVKCQADVDWAVDILLKED----ELNAATGS------DQIG-FEETIDSEEAAQFQ 455
            ..|..|.||:.:|..|:.||..:||..:    |..|...|      .|:| |...:|.:|....:
Mouse  1119 FSLEALKDLYERCNKDIIWATSLLLDSETKLCEDTAVESSPKSYSESQVGPFSMGLDLKEIISHR 1183

  Fly   456 CDCDKAVEAQESPISTPICASPTLPVSKTESKPQRQP-------RNKRASAPTNKELQLKI---- 509
                ...|...|.:|.   .||.:.:..|.::....|       ..:||..|.|.||..::
Mouse  1184 ----GTSEGSNSSVSE---FSPGIGIRNTSARSAGNPGKGTSEQEGRRAMNPENPELITRVFPNA 1241

  Fly   510 -----QNCFVLGDEQ------------------------YSEHTRKI-----RDIRNGILDQPTV 540
                 .|...|.|.|                        .||..:.:     ||..:..|:...:
Mouse  1242 AVKVKSNNETLPDRQAELPGAYTFKQPLSLTPRSYIPKDVSEIEKNLVMTETRDNMHSFLNLSDI 1306

  Fly   541 PKLLEAPEEPELEE------------------------------QEEEEDPEENTLLEIDLGGTL 575
            .....:...|||.|                              .|::::.|:|.:........:
Mouse  1307 INSATSTSNPELNEDVYLTGSLEVKKNENLPKDYVKFANMEEFINEDKQEMEKNLMPGSGWSAGV 1371

  Fly   576 IEQLRAQFHTEDEL-------------LPPEQELPTATKIFMP------------------RQLA 609
            .|:.:|:..|...:             ||||... ...::|.|                  ..||
Mouse  1372 SEEGKAEVLTPTPVTATSLTIDCLELALPPELAF-QLNELFGPVGIDSGSLTVEDCVVHIDLNLA 1435

  Fly   610 KQLYMLWMEAVFNQLEEIRQQTMRDDE--QFARLLKHPGYADCSESPSN-----------VAELL 661
            |.::..|.|:|   :|..||:.:...:  |...|..|.|..:..:..|.           ..|.|
Mouse  1436 KVIHEKWRESV---MERQRQEEVSRGKRTQDPLLAGHTGLDNFEQKSSQKTGKRLLKTLAAPETL 1497

  Fly   662 DMELAWSIYN---------SEQLAAKKAAELTARKQT---PTDIATHLTKMKLCETFPDVPTDTV 714
            |   .|:...         ||::|.::..:|  :::|   ..|.||.|.:.:|.:.||.:..:.:
Mouse  1498 D---HWNTQTKKVSLREIMSEEIALQEKHDL--KRETLMFEKDCATKLKEKQLFKIFPAINQNFL 1557

  Fly   715 LEVFAATGSNYVQTVEVLDSNVKSMLSKAELYDKALREGEKLSEQMALEERRQQQQQKQHNSSGQ 779
            :::|.....:...||:.|:               .:.||:.:...:|     |:...:..|::..
Mouse  1558 VDIFKDHSYSLENTVQFLN---------------CVLEGDPVKTVVA-----QECVHQNENNTYT 1602

  Fly   780 GQRSSSSSYASGRSPQLQEEVKCAALRDFE-----ETRNMAAHHSQLKAECYLKAKQAVQRGNSS 839
            .|:|....  :.:..:.::.....:.:|||     :.|..|..|.|.:.|||.|||:|.:.|..:
Mouse  1603 AQKSKEKK--AKKPKEAEDSPGDPSFQDFEYPEYDDYRAEAFLHQQKRMECYSKAKEAYRMGKKN 1665

  Fly   840 VALYYSEIAKLHKQKIDVFNQRAANCIMEVHRHTQNNPDLLDLHYLHTVEAISCLDLFLDRHIT- 903
            ||.:|::...||:||:...|..||..|.|....:....::||||.||..|||        .|:|
Mouse  1666 VATFYAQQGSLHEQKMKEANHLAAVEIFEKVNASLLPQNVLDLHGLHVDEAI--------EHLTA 1722

  Fly   904 VLRNTTRVYK------HVFIITGRGLHSANGVSTIKNRVKARLGERRLRWQEVNPGLLRV 957
            ||:..|..:|      ::.:|||||.||..||:.||..|...|.....|:.|:.||.|:|
Mouse  1723 VLQQKTEEFKQSGGKPYLSVITGRGNHSQGGVARIKPAVIKYLTSHSFRFSEIKPGCLKV 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627	67/340 (20%)
		AAA_33	105..245	CDD:290396	56/139 (40%)
		GluZincin	606..>707	CDD:301352	28/125 (22%)
		DUF1771	812..868	CDD:285756	23/55 (42%)
		SMR	877..960	CDD:214676	34/88 (39%)
N4bp2	XP_006504066.1	CUE_N4BP2	74..114	CDD:270548
		COG5099	199..>360	CDD:227430
		AAA_33	479..605	CDD:379324	54/132 (41%)
		DUF1771	1636..1697	CDD:369980	24/60 (40%)
		SMR	1703..1785	CDD:214676	34/88 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5348
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3218
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48413at33208
OrthoFinder	1	1.000	-	-		FOG0001378
OrthoInspector	1	1.000	-	-		otm42905
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46535
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1948
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.100