DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7139 and N4bp2

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_017454948.1	Gene:	N4bp2 / 305342	RGDID:	1565738	Length:	1759	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	262/1373 - (19%)
Similarity:	415/1373 - (30%)	Gaps:	582/1373 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LMIIMRGPSGSGKSTLAESLLRQAHLLDRHQVRDFVLSSDDYFKTRRGYVFNPTLLPAAHEWNQQ 168
            :::::||..|||||.||.:       |........:||:||||.....|.|:...|..||||||.
  Rat   447 VLVLLRGLPGSGKSFLART-------LQEDNPGGVILSTDDYFYINGQYQFDVKYLGEAHEWNQN 504

  Fly   169 RVRDKAASGWSPIIVDNTNTMVWEMQPYVQFAVRHGYVIELLEPNTSWCKSASKLAQKNVHNVPR 233
            |.::......||:|:||||...|||:|||..:.:|.|.:...||:|.|.....:||::|:|.|.:
  Rat   505 RAKEAFEKKVSPVIIDNTNLQAWEMKPYVALSQKHKYKVLFREPDTWWKFKPKELARRNIHGVSK 569

  Fly   234 ENIQRMLERFERTTA--------------------------------GELIQLMKETKYSVELPQ 266
            |.|.||||.::|..:                                .|.:...||...|...|:
  Rat   570 EKISRMLEHYQRFVSVPIIMSSSDPEKTERIELCAYACEDRNSSPRDSEAVTSTKEENVSSASPK 634

  Fly   267 ------------------LRNHPPLPAVPI-----------------------ITSFEESKLLEA 290
                              ..:.||||...:                       .|.|..:   |.
  Rat   635 HLDLTEEKTLEVATQAVLPSSEPPLPPTSLNRGRKELGDGSHSVHGHFIQEDPSTYFPNA---EG 696

  Fly   291 PVPAPAEN-------AFKLNANAQTWVPYE----------------------------------- 313
            .|.||..:       :.|..:.|..|.|.|
  Rat   697 SVQAPDRSEKEQEVVSAKERSEADAWSPAEGASSNGHCVEGDQEASEFASAATLPRENPSPPEIL 761

  Fly   314 ----------------------------------------------------------------- 313

  Rat   762 EERTAGKKKTIGKQKSKSSLEKPKPELSNFVGDWPVDKTISQRTKRNRKTEKGSSVQNDKKCNRP 826

  Fly   314 -----------------------HG------APS------------------------------- 318
                                   ||      .||
  Rat   827 QSHKVLDTRVSVNTDPIQPQGSPHGNDDPSEVPSNYHYDPYKSTEQTSFSTVSDWPSSASLAQRE 891

  Fly   319 ----------------------------------YWSQTVNSVDT-------------------- 329
                                              ||..:...:.|
  Rat   892 HRSRMPKAGLSEPNVEFGTNDKLGEIPLYPAHEAYWGTSPEELKTLSSNLRSSEVLPSKTAHEHH 956

  Fly   330 ---------GDATVP--------EIPDALGAAA----PV-------------------------- 347
                     |..|:|        .:|..:|..|    ||
  Rat   957 QTPLSQMVPGQHTLPLPFPSSAATLPGVVGPRALTEFPVGVSGIVSGVDTGTCTQTEPQDFALLW 1021

  Fly   348 ---KSELSIID------------------LLREENQIKVVPSKAESSGAKPLEMHSLDCPNEPKG 391
               |:::|:.|                  |.|:.|..:.:|.:.....:..:|...|...:|.:.
  Rat  1022 KIEKNKISVSDSVRVLTGRVDGFKPKDFTLNRKLNVQETIPYRVMHDKSTFVEESELTNADESEN 1086

  Fly   392 FAHLRQMYPNKQLAGLWDLFVKCQADVDWAVDILLKEDELNAATGSDQIGFEETIDSEEAAQFQC 456
            ...|.:::.:..|..|.||:.:|..|:.||..:|| :.|......::.:...|:....:...|..
  Rat  1087 LNILCKLFGSFSLEALKDLYERCNKDIIWATSLLL-DSETKLCEDAEVVNPPESYSESQVGPFSM 1150

  Fly   457 DCD-KAV-------EAQESPISTPICASPTLPVSKTESKPQRQPRNK-------RASAPTNKE-- 504
            ..| |.:       |...|.:|.   .||.:.:..|.::....|...       ||..|.|.|
  Rat  1151 GLDLKEIISHRGTSEGSNSCVSE---FSPGIGIRNTSAQSDGDPEKGNSEQEGIRAINPENPESV 1212

  Fly   505 --------LQLKIQN---------------------CFVLGDEQYSEHT--RKIRDIRNGILDQP 538
                    :.:|..|                     .:|..|....|.:  .:.||..:..|:..
  Rat  1213 ARIFPNATVNVKSSNGMAPDLSGAYTFKQPLSLTPRSYVPKDVSEIEKSLVTETRDNIHSFLNLS 1277

  Fly   539 TVPKLLEAPEEPELEE----------------------------------QE------------- 556
            .:.....:...|||.|                                  ||
  Rat  1278 DIINSATSTSNPELNEDVYLTGSLEVKKNENLPKDYVKFANMEEFINEDKQEMEKSLMPGTGWSA 1342

  Fly   557 ---EEEDPEENTLLEIDLGGTLIEQLRAQFHTEDEL-LPPE-----QEL--PTATK--------- 601
               ||..||.:|...:......|:.|        || ||||     .||  |....
  Rat  1343 GVSEESKPEVSTPAPVAAKSLTIDCL--------ELTLPPELAFQLNELFGPVGVDSGSLTVEDC 1399

  Fly   602 -IFMPRQLAKQLYMLWMEAVFNQLEEIRQQTMRDDEQFARLLKHPGYA-----DCSESPSN---- 656
             :.:...|||.::..|.|:|   :|..||    ::....:.::.|..|     |.||..|:
  Rat  1400 VVHIDLNLAKVIHEKWRESV---MERQRQ----EEVSLGKRMQDPSLAGHTVLDNSEQKSSQKTG 1457

  Fly   657 --------VAELLDMELAWSIYN---------SEQLAAKKAAELTARKQT---PTDIATHLTKMK 701
                    ..|.||   .|:...         ||::|.::..:|  :::|   ..|.||.|.:.:
  Rat  1458 KRLLKTLAAPETLD---HWNTQTKKVSLREIMSEEIALQEKHDL--KRETLMFEKDCATKLKEKQ 1517

  Fly   702 LCETFPDVPTDTVLEVFAATGSNYVQTVEVLDSNVKSMLSKAELYDKALREGEKLSEQMALEERR 766
            |.:.||.:..:.:.::|.....:...||:.|:               .:.||:.:...:|.|...
  Rat  1518 LFKIFPAINQNFLADIFKDHNYSLENTVQFLN---------------CVLEGDPVKTVIAQECAH 1567

  Fly   767 QQQQQKQHNSSGQGQRSSSSSYASGRSPQLQEEVKCAALRDFE-----ETRNMAAHHSQLKAECY 826
            |.:....|::....::.:.      :..:..:.....:.:|||     :.|..|..|.|.:.|||
  Rat  1568 QNESNTSHSAQKSKEKKAK------KPKEADDTAGDPSFQDFEYPEYDDYRAEAFLHQQKRMECY 1626

  Fly   827 LKAKQAVQRGNSSVALYYSEIAKLHKQKIDVFNQRAANCIMEVHRHTQNNPDLLDLHYLHTVEAI 891
            .|||:|.:.|..:||.:|::...||:||:...|..||..|.|....:....::||||.||..|||
  Rat  1627 SKAKEAYRMGKKNVATFYAQQGSLHEQKMREANHLAAVEIFEKVNASLLPQNVLDLHGLHVDEAI 1691

  Fly   892 SCLDLFLDRHIT-VLRNTTRVYK------HVFIITGRGLHSANGVSTIKNRVKARLGERRLRWQE 949
                    .|:| ||:..|..:|      ::.:|||||.||..||:.||..|...|.....|:.|
  Rat  1692 --------EHLTAVLQQKTEEFKQSGGKPYLSVITGRGNHSQGGVARIKPAVIKYLTSHSFRFSE 1748

  Fly   950 VNPGLLRV 957
            :.||.|:|
  Rat  1749 IKPGCLKV 1756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627	66/221 (30%)
		AAA_33	105..245	CDD:290396	56/139 (40%)
		GluZincin	606..>707	CDD:301352	29/129 (22%)
		DUF1771	812..868	CDD:285756	23/55 (42%)
		SMR	877..960	CDD:214676	34/88 (39%)
N4bp2	XP_017454948.1	CUE_N4BP2	47..87	CDD:270548
		AAA_33	455..581	CDD:404546	54/132 (41%)
		DUF1771	1610..1671	CDD:400763	24/60 (40%)
		SMR	1677..1759	CDD:214676	34/88 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3689
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48413at33208
OrthoFinder	1	1.000	-	-		FOG0001378
OrthoInspector	1	1.000	-	-		otm44976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46535
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.070