DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7139 and SPCC1235.03

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_587729.2	Gene:	SPCC1235.03 / 2539296	PomBaseID:	SPCC1235.03	Length:	502	Species:	Schizosaccharomyces pombe

Alignment Length:	557	Identity:	120/557 - (21%)
Similarity:	203/557 - (36%)	Gaps:	174/557 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   517 DEQYSEH--TRKIRDIRNGILDQPTVPKLLEAPE-EPELEEQEEEED---PEENTLLEIDLGGTL 575
            :|.||.:  :..:..|.|...|..|..::|||.. |.:.:..||..|   .:|..||.:.   ||
pombe     9 EEYYSRYLDSALVLAIVNDSDDSNTAREILEALSIESQCDSHEEHWDNLRRDEQELLNLK---TL 70

  Fly   576 IEQLRAQFHTED---ELLPPEQELPTATKIFMPRQLAKQLYMLWMEAVFNQLEEIRQQTMRDDEQ 637
            .|::. :...||   ||.....||......|             :.::|:.|...|.|.::
pombe    71 DEEIN-KIDEEDFTWELKDSSLELDPDVYNF-------------LRSMFSDLSAARVQLVQ---- 117

  Fly   638 FARLLKHPGYADC-SESPSNVAELLDMELAWSIYNSEQLAAKKAAELTA-------RKQTPTDIA 694
                      |.| ::...:..|||:..   :|..|||:.....|.:|:       :::..|..|
pombe   118 ----------AKCQNDLVRSSDELLNHR---AIQESEQIETAADALITSNIGHRSRQRKKKTKKA 169

  Fly   695 THLTK--MKLCETFPDVPTDTVLEVFAATGSNYVQTVEVLDS--NVKSMLSKAELYDKA------ 749
            |:..|  .|......:|..|.:|:...:...|....:|.|.|  |:.|.....|.|..:
pombe   170 TNSRKPLSKFQSNTEEVNEDPILKPSLSVWENNRLLIEKLTSILNIPSSQINHEFYKNSSAWPIT 234

  Fly   750 ----LREGEKLS-----EQMALEERRQQQ-------------------------------QQKQH 774
                :...:.||     |.|..:|...|.                               ::.||
pombe   235 IRNLIHRHQPLSNITNNELMKYQEEATQLAKDTGLSLKICTDVLICSNDYKNALWILCLIKETQH 299

  Fly   775 NSSG------QGQRSSSSSYA----SGRSPQLQEEVKCAALRD-------FEETRNMAAHHSQLK 822
            |..|      |..:|:||:..    :.:|.:|.|:.:..:..|       :.|.|||...:|
pombe   300 NEMGNIKLSSQTAKSNSSTQTKTCLNDQSSKLVEDDEALSAEDCNRLAEEYLELRNMQYSNS--- 361

  Fly   823 AECYLKAKQAVQRGNSSVALYYSEIAKLHKQKIDVFNQRAANCIMEVHRHTQNNPDLLDLHYLHT 887
            |:.|.::|.....|.|  |:|::::.:.:.:|...:...|...:  .|..|.::   ||||....
pombe   362 AKEYRRSKSNHLFGGS--AMYHAQLGREYHEKALKYRSLAMRSL--AHSGTSHS---LDLHGATV 419

  Fly   888 VEAISCLDLFLDRHITVLR---------------NTTRVYKHVFIITGRGLHSANGVSTIKNRVK 937
            .||           .|::|               |:.|.:   .|:||||.||..        ::
pombe   420 REA-----------KTIVRERVAAWWAKEADTSPNSIRPF---VIVTGRGNHSIG--------LE 462

  Fly   938 ARLGERRLR------WQ-EVNPGLLRVKVFSASRHSK 967
            |||....:|      |: :...|  ::.|:..:||||
pombe   463 ARLLPAIVRLLQQDHWRFDAEHG--QITVYGINRHSK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627
		AAA_33	105..245	CDD:290396
		GluZincin	606..>707	CDD:301352	20/110 (18%)
		DUF1771	812..868	CDD:285756	13/55 (24%)
		SMR	877..960	CDD:214676	23/104 (22%)
SPCC1235.03	NP_587729.2	SMR	409..492	CDD:214676	24/109 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46535
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910