DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7139 and Cnp

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_034053.2	Gene:	Cnp / 12799	MGIID:	88437	Length:	420	Species:	Mus musculus

Alignment Length:	350	Identity:	78/350 - (22%)
Similarity:	145/350 - (41%)	Gaps:	94/350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 KLMIIMRGPSGSGKSTLAESLLRQAHLLDRHQVRDFVLSSDDYFKTRRGYVFNPTLLPAAH-EWN 166
            |.:.|:||..||||||||..:|.:.|  |..:    ::|:|.|           .::|.:. :::
Mouse    50 KTLFILRGLPGSGKSTLARLILEKYH--DGTK----MVSADAY-----------KIIPGSRADFS 97

  Fly   167 QQRVR-DKAASGW-----SPIIVDNTNTMVWEMQPYVQFAVRHGYVIELLEPNTSWCKSASKLAQ 225
            :...| |:..:|:     ..:::|:||.....:....:.|.::.|.:.|:||.|:|....::|.:
Mouse    98 EAYKRLDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQLKE 162

  Fly   226 KNVHNVPRENIQRMLERFERTTAGELIQLMKE---TKYSVE---------LPQLRNH-------- 270
            ||...:..::::::....|:    :.:.|...   ||.|.|         |.:|.||
Mouse   163 KNQWQLSADDLKKLKPGLEK----DFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELR 223

  Fly   271 ------PPLPAVPIITSFEE---------SKLLEAPVPAPAE-------------NAFKLNANAQ 307
                  .|...:.:::.|.:         :|..:....|.||             .||||:.:|.
Mouse   224 HFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISAL 288

  Fly   308 TWVPYEHGAP--------SYWSQTVNSVDTGDATVP--EIPDALGAAA---PVKSELSIIDLLRE 359
            ...|...||.        ..|...::.....:...|  .....||.||   ||::.|.::|:|:
Mouse   289 FVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQ- 352

  Fly   360 ENQIKVVPSKAESSGAKPL-EMHSL 383
              |:| ..|:.|:.|..|. :::||
Mouse   353 --QVK-GGSQGEAVGELPRGKLYSL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627	45/204 (22%)
		AAA_33	105..245	CDD:290396	34/146 (23%)
		GluZincin	606..>707	CDD:301352
		DUF1771	812..868	CDD:285756
		SMR	877..960	CDD:214676
Cnp	NP_034053.2	NK	51..>165	CDD:302627	33/130 (25%)
Cnp	NP_034053.2	CNPase	186..398	CDD:283525	41/192 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810