DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7139 and N4BP2L2

DIOPT Version :9

Sequence 1:	NP_649378.1	Gene:	CG7139 / 40448	FlyBaseID:	FBgn0027532	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_016875813.1	Gene:	N4BP2L2 / 10443	HGNCID:	26916	Length:	1193	Species:	Homo sapiens

Alignment Length:	896	Identity:	194/896 - (21%)
Similarity:	311/896 - (34%)	Gaps:	279/896 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NNNNNNNNNNNNNNNNDNNNCGRSKSGGTHRKYATAEAPSSIRMCPASNLNSNQSNKQFNSIC-- 95
            ||.:.|.|....:.||:..:|..::| ..|               |:.|..|.|.....|..|
Human   320 NNCHVNWNCMTFDQNNEYTDCSENRS-SVH---------------PSGNGCSMQDRYVSNGFCEV 368

  Fly    96 -QRAQAGH-------------------------KLMIIMRGPSGSGKSTLAESLLRQAHLLDRHQ 134
             :|....|                         ||:|::||..||||:||:..||.|.
Human   369 RERCWKDHCMDKHNGTDRFVNQQFQEEKLNKLQKLLILLRGLPGSGKTTLSRILLGQN------- 426

  Fly   135 VRD-FVLSSDDYFKTRRGYVFNPTLLPAAHEWNQQRVRDKAASGWSPIIVDNTNTMVWEMQPYVQ 198
             || .|.|:||||..:.||.:|...|..||:|||.|.:.....|.||:|:||||...|||:|||:
Human   427 -RDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRSPVIIDNTNIQAWEMKPYVE 490

  Fly   199 FAVRHGYVIELLEPNTSWCKSASKLAQKNVHNVPRENIQRMLERFERTTAGELI----------- 252
            .|:..||.:|..||.|.|.....:|.::|.|.|.|:.|.:||:|:|...:..::
Human   491 VAIGKGYRVEFHEPETWWKFDPEELEKRNKHGVSRKKIAQMLDRYEYQMSISIVMNSVEPSHKST 555

  Fly   253 ------------QLMKETKYSV-ELPQLRNHPPLPAVPIITSFEESKLLE----------APVPA 294
                        :::|:|.:.: :..|.||..............|...||          .|..:
Human   556 QRPPPPQGRQRERVLKKTGHRLSKTKQKRNRKRNKKQNSQNRIMEENSLEFLSDLTPGDQDPSQS 620

  Fly   295 PAENAFKLNANAQTWVPYEHG--------APSYWSQTVNSVDTGDA-----TVPEIPDALGAAAP 346
            ..|:..|....::  .|:..|        ...|..:...:.|..|:     ::.|:.:.......
Human   621 EEEDIEKTRRESE--YPFIDGLQNEVGDFVTGYKEKRWKNKDPKDSFQNVMSIVELDNTPKNYLS 683

  Fly   347 VKSELSIIDLLREENQIKVV----------PSKAESSGAKPLEMH-------SLDCPN------- 387
            .:.:...:.||...|:|.|.          .:..:.||.| :|.|       :||..:
Human   684 KEGDNLFVSLLLRPNEISVTCPILTQNLSCVTTDDCSGMK-VEKHIRNRHTIALDTQDLSAETSC 747

  Fly   388 --------EPKGFAH----------------LR--QMYPNKQLAGLWDLFVKCQADVD------- 419
                    ..|..:|                ||  |:|..|  ...|..|....:|.|
Human   748 LFMKKREIVDKNLSHEPILCHQHGIRMSDKVLREEQVYTTK--INHWAFFTTNLSDEDLQLGSDR 810

  Fly   420 ------WAV-------DILLKEDELNAATGSDQIG------FEETIDSEEAAQFQCDCDKAV--- 462
                  |..       :...|:|......|.|..|      |.....||.....:...||.:
Human   811 QPYFGSWPAGPHKFICEQRPKKDRACKLAGPDSRGQWIQMIFTSVAASEPGNNPEILTDKLLIGN 875

  Fly   463 -------EAQESPISTPICAS----PTLPVSKTESKPQRQPRNKRASAPTNKELQLKIQNCFVLG 516
                   |..:|.|.|.:..|    |.:|.:..||...::.|.||        :...:.|..:||
Human   876 EDFSPPPETMDSFIETNLFRSCLPQPDIPKNALESTKNKKRRKKR--------IFNLVPNFDLLG 932

  Fly   517 DEQYSEHTRKIRDI---RNGILDQPTVPKLLEAPEEPELEEQEEEEDPEEN-------------- 564
            ..:.....|:..|:   .:|:       |:....|:..:.|:..||:.::.
Human   933 QSRIGVKEREKCDLLTKNHGL-------KITLGEEKDRISERNSEEENKQKLMTFDHHPLWFYLD 990

  Fly   565 ----TLLEIDLGG------TLIEQLRAQFHTEDELLPPEQELPTATKIFMPRQLAKQLYMLW--M 617
                |.|.||  |      ....:||.........: |...|...:.|:.|....|:|::.:  .
Human   991 IIKATPLNID--GQRYSHCLSFNRLRCSASLYKNYI-PSFVLHNLSSIWKPSFTNKKLFLTFESQ 1052

  Fly   618 EAVFNQLEEIRQQTMRDDEQFAR---LLKHPGYADCSESPSN----VAELLDMEL-AWSIYNSEQ 674
            ..|.|:|         :|..|..   |..||. ..||...::    :.|..|.:| .|.  ..::
Human  1053 TRVGNKL---------NDAGFISPEILHSHPD-TSCSLGVTSDFHFLNERFDRKLKRWE--EPKE 1105

  Fly   675 LAAKKAAELTARKQTPTDIATHLTKMKLCETF----------PDVPTDTVL 715
            |.|:.:.:||:     ||..:  .::.|.:.|          |.||.:::|
Human  1106 LPAEDSQDLTS-----TDYRS--LELPLSQGFAFQLVKLFGSPGVPMESLL 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7139	NP_649378.1	NK	105..277	CDD:302627	67/196 (34%)
		AAA_33	105..245	CDD:290396	61/140 (44%)
		GluZincin	606..>707	CDD:301352	24/120 (20%)
		DUF1771	812..868	CDD:285756
		SMR	877..960	CDD:214676
N4BP2L2	XP_016875813.1	AAA_33	404..536	CDD:316215	61/139 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5690
eggNOG	1	0.900	-	-		E1_KOG2401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48413at33208
OrthoFinder	1	1.000	-	-		FOG0001378
OrthoInspector	1	1.000	-	-		otm40831
orthoMCL	1	0.900	-	-		OOG6_106095
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1948
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750