DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act79B and Actr5

DIOPT Version :9

Sequence 1:	NP_001262200.1	Gene:	Act79B / 40444	FlyBaseID:	FBgn0000045	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_780628.3	Gene:	Actr5 / 109275	MGIID:	1924748	Length:	608	Species:	Mus musculus

Alignment Length:	546	Identity:	122/546 - (22%)
Similarity:	201/546 - (36%)	Gaps:	187/546 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVVDNGSGMCKAGFA--GDD---APRAVFPSIVGRPRHQGVMVGMGQKDCYVGDEAQSKRGI-LS 67
            ||:||||...:||:|  |.|   .||..|.::..|.| .|...|.|.:   ||:...|...: ..
Mouse    33 LVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGR-GGARGGPGPQ---VGNALGSLEPLRWM 93

  Fly    68 LKYPIEHGIITNWDDMEKVWHHTFYNELRVAPE---EHPVLLTEAPLNPKANREKMTQIMFETFN 129
            |:.|.:..:..|.:..|.:..::| ..|.|:.:   :||::||||..||..:|:.|::::||.:.
Mouse    94 LRSPFDRNVPVNLELQELLLDYSF-QHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYR 157

  Fly   130 SPAMYVAIQAVLSLY----ASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYL 190
            .|.:...|.::.|.|    .:..::|:::.||...:|.:|:.||........|::|.|.....||
Mouse   158 IPKVAYGIDSLFSFYHNVPKNALSSGLIISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYL 222

  Fly   191 MK--------------------ILTERGY----------------------------------SF 201
            .:                    ||.|..|                                  ..
Mouse   223 QRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYGAELQKWQCPDYYENNVHKMQLPFSSKLLGS 287

  Fly   202 TTTAER------------------------EIVRDIKEKLCYVA-------------------LD 223
            |.|||.                        ::.::..|:|.||.                   :|
Mouse   288 TLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEEGQMDQFHKALIELNMD 352

  Fly   224 FEQEMAT----------------AAASTSLE-----KSYELPD---------------------- 245
            ..:|:.:                ..|..|||     ...|.||
Mouse   353 SPEELQSYIQKLTLAVEQAKQKILQAEASLEVDVVDSKPETPDLEPLEPTMEDVENISDFEPLFS 417

  Fly   246 --------GQVIT--------------IGNERFRTPEALFQPSFLGMESCGIHETVYQSIMKCDV 288
                    .||.|              :|.||.|.||.:||||.:|.|..||.||::..:.:...
Mouse   418 EETPEVEKPQVTTVQPVFNLAAYHQLSVGTERIRAPEIIFQPSLIGEEQAGIAETLHFVLDRYPK 482

  Fly   289 DIRKDLYANNVLSGGTTMYPGIADRMQKEITALAP--STIKIKIIAPPERKYSVWIGGSILASLS 351
            .|:..|..|..|:||..||||:..|::||:..:.|  |:.::::.:.|  ....|.|....| |.
Mouse   483 AIQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNP--VLDAWYGARDWA-LD 544

  Fly   352 TFQQ--MWISKQEYDESGPGIVHRKC 375
            ..:.  .|:::::|:|.|...:...|
Mouse   545 HLEDSGAWVTRKDYEEKGGEYLKEHC 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act79B	NP_001262200.1	PTZ00281	1..376	CDD:173506	122/546 (22%)
Actr5	NP_780628.3	NBD_sugar-kinase_HSP70_actin	27..570	CDD:302596	121/544 (22%)
		ACTIN	32..562	CDD:214592	120/536 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910