DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act79B and ACTL7B

DIOPT Version :9

Sequence 1:	NP_001262200.1	Gene:	Act79B / 40444	FlyBaseID:	FBgn0000045	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_006677.1	Gene:	ACTL7B / 10880	HGNCID:	162	Length:	415	Species:	Homo sapiens

Alignment Length:	369	Identity:	161/369 - (43%)
Similarity:	229/369 - (62%)	Gaps:	5/369 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDCYVGDEAQSKRGILSLKYPI 72
            |:::|.||..||.|:||:..|.....|.||:...:....|..:|...||.|..:....|.|..|:
Human    51 AVIIDLGSQYCKCGYAGEPRPTYFISSTVGKRCPEAADAGDTRKWTLVGHELLNTEAPLKLVNPL 115

  Fly    73 EHGIITNWDDMEKVWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAI 137
            :|||:.:||.::.:|.:.|...:::.||||.||:::.||:|.:||||..::|||||..|||:|..
Human   116 KHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAMHVTS 180

  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFT 202
            |::||:|:.|:|:|:|::||.||||.|||.||..||....|.|.||.|||:|||::|.|.|::||
Human   181 QSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAGHAFT 245

  Fly   203 TTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRTPEALFQPSF 267
            .. ...|:..||:|.||.|...|:|:  ......|...||||||::||||.||||..|.|||||.
Human   246 DD-HLHIIEHIKKKCCYAAFLPEEEL--GLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSL 307

  Fly   268 LGMESCGIHETVYQSIMKC-DVDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKII 331
            .|....|:.|.....:.:| |...::::.||.:|.||.||..|..:|.|:|::.|.|.. ...:.
Human   308 AGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGD-SPAVA 371

  Fly   332 APPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375
            |.||||.|||.||||||||..|||:|:||:|::|.|...::.||
Human   372 AAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSVAIYSKC 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act79B	NP_001262200.1	PTZ00281	1..376	CDD:173506	161/369 (44%)
ACTL7B	NP_006677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
ACTL7B	NP_006677.1	NBD_sugar-kinase_HSP70_actin	51..415	CDD:327376	159/367 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910