DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and proA

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_414778.1	Gene:	proA / 946680	ECOCYCID:	EG10767	Length:	417	Species:	Escherichia coli

Alignment Length:	410	Identity:	147/410 - (35%)
Similarity:	258/410 - (62%)	Gaps:	11/410 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VEVMAENARTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRL 412
            :|.|...|:..|.::..|:..::...:..:||.|.::.:.||:|||:|:|:|:.:||::.:|.||
E. coli     2 LEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSEAMLDRL 66

  Fly   413 SLNPAKLKNLSVGLKQIAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVA 477
            :|.||:||.::..::|:...:.. ||:|:....|...|.|::..||:||:.||:|:||:....||
E. coli    67 ALTPARLKGIADDVRQVCNLADP-VGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVA 130

  Fly   478 ALAMASANGLLLKGGKEAAHSNKALMELVKEALATVG-AEHAVSLVST--REEISDLLSMENHID 539
            :|.:.:.|.::|:||||...:|.|.:.::::||.:.| ...||..:..  |..:|::|.|:.:||
E. coli   131 SLCLKTGNAVILRGGKETCRTNAATVAVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYID 195

  Fly   540 LIIPRGSSDLVRSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETL 604
            ::||||.:.|.:..::||. |||:....||||:|:|...::.:||::..:||...|:.||.:|||
E. coli   196 MLIPRGGAGLHKLCREQST-IPVITGGIGVCHIYVDESVEIAEALKVIVNAKTQRPSTCNTVETL 259

  Fly   605 LIHEDLMSGAIFGDVCNMLKREGVKIYAGPRLNQQLTFGPPAAKSLK-----HEYGALECCIEVV 664
            |::::: :.:....:...:...||.::|......||..||....::|     .|:.:|:..:::|
E. coli   260 LVNKNI-ADSFLPALSKQMAESGVTLHADAAALAQLQAGPAKVVAVKAEEYDDEFLSLDLNVKIV 323

  Fly   665 PSLDEAINHIHTYGSSHTDVIVTENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEVGIST 729
            ..||:||.||..:|:.|:|.|:|.:...|::|:..|||:.|:.|||:||.||.:|||||||.:||
E. coli   324 SDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVST 388

  Fly   730 ARIHARGPVGVEGLLTTKWI 749
            .::|||||:|:|.|.|.|||
E. coli   389 QKLHARGPMGLEALTTYKWI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789
		P5CS	50..775	CDD:130164	147/410 (36%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	147/409 (36%)
proA	NP_414778.1	proA	1..417	CDD:234685	147/410 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	167	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_COG0014
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	268	1.000	Inparanoid score	I110
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto111875
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	1	1.000	-	-
	11	10.860