DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and PRO2

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_014968.1	Gene:	PRO2 / 854501	SGDID:	S000005850	Length:	456	Species:	Saccharomyces cerevisiae

Alignment Length:	450	Identity:	187/450 - (41%)
Similarity:	276/450 - (61%)	Gaps:	30/450 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 MAENARTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSL- 414
            :|:|||.....::.::...|:..:..:.|.|.:....|.:||..|||.|:::|||..||.||.|
Yeast     7 IAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLLKRLDLF 71

  Fly   415 NPAKLKNLSVGLKQIAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAAL 479
            ...|.:.:..|:|.:|| ....||:|.....|.|.|.|.|||.|:|||||||||||:.:..:.||
Yeast    72 KGDKFEVMLQGIKDVAE-LEDPVGKVKMARELDDGLTLYQVTAPVGVLLVIFESRPEVIANITAL 135

  Fly   480 AMASANGLLLKGGKEAAHSNKALMELVKEALATVGAE-----HAVSLVSTREEISDLLSMENHID 539
            ::.|.|..:||||||:.::.:.:.::|.:.:|...:|     .:|.|:.||:::||||..:.:||
Yeast   136 SIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLIETRQDVSDLLDQDEYID 200

  Fly   540 LIIPRGSSDLVRSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETL 604
            |::||||:.|||.| :.:..|||||||:|:|.:|:|.||||.||.||:.|||.:|||.|||||||
Yeast   201 LVVPRGSNALVRKI-KDTTKIPVLGHADGICSIYLDEDADLIKAKRISLDAKTNYPAGCNAMETL 264

  Fly   605 LIHEDLMSGAIFGDVCNMLKRE-GVKIYAG--------PRLN---------QQLTFGPPAAKSLK 651
            ||:.....   :.:|...|..| ||.|:|.        .:||         |..|......:...
Yeast   265 LINPKFSK---WWEVLENLTLEGGVTIHATKDLKTAYFDKLNELGKLTEAIQCKTVDADEEQDFD 326

  Fly   652 HEYGALECCIEVVPSLDEAINHIHTYGSSHTDVIVTENDAAARQFLGSVDSACVFHNASSRFADG 716
            .|:.:|:...:.|.|.:.||.||:|:.|.|||.|||||.|.|.:|:..|||:.|:.|||:|||||
Yeast   327 KEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWNASTRFADG 391

  Fly   717 FRFGLGAEVGISTARIHARGPVGVEGLLTTKWILEGQDHAAADF-AEGGGRTWLHETLPL 775
            ||:|.||||||||::||||||||::||::.::.:.|....|:|: ..||.:.::|:.|.:
Yeast   392 FRYGFGAEVGISTSKIHARGPVGLDGLVSYQYQIRGDGQVASDYLGAGGNKAFVHKDLDI 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789
		P5CS	50..775	CDD:130164	187/448 (42%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	180/425 (42%)
PRO2	NP_014968.1	proA	11..422	CDD:161862	178/415 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344684
Domainoid	1	1.000	202	1.000	Domainoid score	I556
eggNOG	1	0.900	-	-		E1_COG0014
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I469
Isobase	1	0.950	-	0.975504	Normalized mean entropy	S1064
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto99901
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R982
SonicParanoid	1	1.000	-	-		X2479
TreeFam	1	0.960	-	-
	14	13.730