DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7470 and ALDH18A1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_024303862.1	Gene:	ALDH18A1 / 5832	HGNCID:	9722	Length:	829	Species:	Homo sapiens

Alignment Length:	830	Identity:	446/830 - (53%)
Similarity:	563/830 - (67%)	Gaps:	70/830 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAQSLRNGF-----YRNAW----RAFSSHGPRQPLVSPERR----------LEKAH-PTFTERSQ 52
            |:|..|.||     :...|    ..|.||..:..::...|.          |.:.| .:|..||:
Human     2 LSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKSFAHRSE 66

  Fly    53 LKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLEGREVMMVTSGAVAFGKQKLAQEL 117
            ||:|:|:||||||||:||.|..||||||||||||||:....:|||:|:|||||||||||:|..|:
Human    67 LKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEI 131

  Fly   118 LMSLSMRETLNPKDS--KEFDGATLEPRAAAAVGQSGLMSLYDAMFAQYGVKIAQVLVTKPDFYN 180
            |:|.|:|:.|:...:  ||.....||.||.||.||||||:||:|||.||.:..||:|||..||::
Human   132 LLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHD 196

  Fly   181 EETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDEPAGGAR--RGIPIKDNDSLSAMLAAE 243
            |:.|.||..||.||:.:|||||:||||||.||.     ||....:  ..|.:||||||:|.||.|
Human   197 EQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPA-----EPNSDLQGVNVISVKDNDSLAARLAVE 256

  Fly   244 VQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSIEFGKKSKVGTGGMDSKVKAATWALDR 308
            ::.||||::|||:|:::.||..|.|||:..:...|..|:.||.||:||.|||::|||||.|||..
Human   257 MKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGMGGMEAKVKAALWALQG 321

  Fly   309 GVSVVICNGMQEK----AIKTIIGGRKVGTFFTEATESANAVPVEVMAENARTGSRQMQALTPAQ 369
            |.||||.||...|    .|..|:.|:||||||:|...:...  ||...|.||:|.|.:..|.|.|
Human   322 GTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPT--VEQQGEMARSGGRMLATLEPEQ 384

  Fly   370 RASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSLNPAKLKNLSVGLKQIAEDSH 434
            ||..::.|||||..:...||.||.|||.||: ..||.|||.||||:.:||.:|::||:|||..|.
Human   385 RAEIIHHLADLLTDQRDEILLANKKDLEEAE-GRLAAPLLKRLSLSTSKLNSLAIGLRQIAASSQ 448

  Fly   435 KNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGKEAAHSN 499
            .:|||||||||:|..|||:||||||||||||||||||.||||||||:||.|||||||||||||||
Human   449 DSVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSN 513

  Fly   500 KALMELVKEALATVGAEHAVSLVSTREEISDLLSMENHIDLIIPRGSSDLVRSIQQQSLHIPVLG 564
            :.|..|.:|||:..|.:.||.||:||||:.||..::..||||||||||.|||.||:.:..|||:|
Human   514 RILHLLTQEALSIHGVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMG 578

  Fly   565 HAEGVCHVYIDRDADLEKALRI----------------------------------ARDAKCDYP 595
            |:||:||:|:|.:|.::|..|:                                  .||:||:||
Human   579 HSEGICHMYVDSEASVDKVTRLGELDGVFSFTTEKYYILCSSGSCQWKQFFAHLLSVRDSKCEYP 643

  Fly   596 AACNAMETLLIHEDLMSGAIFGDVCNMLKREGVKIYAGPRLNQQLTFGPPAAKSLKHEYGALECC 660
            |||||:||||||.||:...:|..:.:||:.|.|||:|||:....|||.|...|||:.|||.||.|
Human   644 AACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLELC 708

  Fly   661 IEVVPSLDEAINHIHTYGSSHTDVIVTENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEV 725
            ||||.::.:||:|||.||||||||||||::..|..||..|||||||.|||:||:||:||||||||
Human   709 IEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEV 773

  Fly   726 GISTARIHARGPVGVEGLLTTKWILEGQDHAAADFAEGGGRTWLHETLPL 775
            ||||:|||||||||:||||||||:|.|:||..:||:|.|...:|||.||:
Human   774 GISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSLKYLHENLPI 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789	164/295 (56%)
		P5CS	50..775	CDD:130164	432/766 (56%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	254/437 (58%)
ALDH18A1	XP_024303862.1	ProB	64..828	CDD:330199	433/768 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151745
Domainoid	1	1.000	314	1.000	Domainoid score	I1289
eggNOG	1	0.900	-	-		E1_COG0014
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2142
Inparanoid	1	1.050	819	1.000	Inparanoid score	I474
Isobase	1	0.950	-	0.975504	Normalized mean entropy	S1064
OMA	1	1.010	-	-		QHG58163
OrthoDB	1	1.010	-	-		D832430at2759
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto90627
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R982
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750