DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7470 and Aldh18a1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_062672.2	Gene:	Aldh18a1 / 56454	MGIID:	1888908	Length:	795	Species:	Mus musculus

Alignment Length:	745	Identity:	441/745 - (59%)
Similarity:	550/745 - (73%)	Gaps:	17/745 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LEKAH-PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLEGREVMMVTS 103
            |.:|| ..|..||:||:|:|:||||||||:||.|..||||||||||||||:....:|||:|:|||
Mouse    53 LSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTS 117

  Fly   104 GAVAFGKQKLAQELLMSLSMRETLNPKDS--KEFDGATLEPRAAAAVGQSGLMSLYDAMFAQYGV 166
            ||||||||:|..|:|:|.|:|:.|:...:  ||.....||.||.||.||||||:||:|||.||.:
Mouse   118 GAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSI 182

  Fly   167 KIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDEPAGGAR--RGIP 229
            ..||:|||..||::|:.|.||..||.||:.:|||||:||||||.||.     ||....:  ..|.
Mouse   183 CAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPA-----EPNSDLQGVNVIS 242

  Fly   230 IKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSIEFGKKSKVGTGG 294
            :||||||:|.||.|::.||||::|||:|:::.||..|.|||:..:...|..|:.||.||:||.||
Mouse   243 VKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGG 307

  Fly   295 MDSKVKAATWALDRGVSVVICNGMQEK----AIKTIIGGRKVGTFFTEATESANAVPVEVMAENA 355
            |::|||||.|||..|.||||.||...|    .|..|:.|:||||||:|...:...  ||...|.|
Mouse   308 MEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPT--VEQQGEMA 370

  Fly   356 RTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSLNPAKLK 420
            |:|.|.:..|.|.|||..:|.|||||..:.:.||.||.|||.||: ..||.|||.||||:.:||.
Mouse   371 RSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAE-GRLASPLLKRLSLSTSKLN 434

  Fly   421 NLSVGLKQIAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASAN 485
            :|::||:|||..|.::|||||||||:|..|||:||||||||||||||||||.||||||||:||.|
Mouse   435 SLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGN 499

  Fly   486 GLLLKGGKEAAHSNKALMELVKEALATVGAEHAVSLVSTREEISDLLSMENHIDLIIPRGSSDLV 550
            ||||||||||||||:.|..|.:|||:..|.:.|:.||:||||:.||..::..||||||||||.||
Mouse   500 GLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLV 564

  Fly   551 RSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETLLIHEDLMSGAI 615
            |.||:.:..|||:||:||:||:|:|.:|.::|..|:.||:||:|||||||:||||||.||:...:
Mouse   565 RDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPL 629

  Fly   616 FGDVCNMLKREGVKIYAGPRLNQQLTFGPPAAKSLKHEYGALECCIEVVPSLDEAINHIHTYGSS 680
            |..:.:||:.|.|||:|||:....|||.|...|||:.|||.||.|||||.|:.|||:|||.||||
Mouse   630 FDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSS 694

  Fly   681 HTDVIVTENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLT 745
            |||||||||:..|..||..|||||||.|||:||:||:||||||||||||:|||||||||:|||||
Mouse   695 HTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLT 759

  Fly   746 TKWILEGQDHAAADFAEGGGRTWLHETLPL 775
            |||:|.||||..:||:|.|...:|||.||:
Mouse   760 TKWLLRGQDHVVSDFSEHGSLKYLHENLPV 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789	164/295 (56%)
		P5CS	50..775	CDD:130164	436/732 (60%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	257/403 (64%)
Aldh18a1	NP_062672.2	Glutamate 5-kinase	1..361		170/312 (54%)
		AAK_P5CS_ProBA	63..354	CDD:239789	164/295 (56%)
		P5CS	64..793	CDD:130164	437/734 (60%)
		Gamma-glutamyl phosphate reductase	362..795		271/431 (63%)
		ALDH_F18-19_ProA-GPR	364..767	CDD:143398	257/403 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841850
Domainoid	1	1.000	319	1.000	Domainoid score	I1253
eggNOG	1	0.900	-	-		E1_COG0014
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2142
Inparanoid	1	1.050	827	1.000	Inparanoid score	I462
Isobase	1	0.950	-	0.975504	Normalized mean entropy	S1064
OMA	1	1.010	-	-		QHG58163
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto94216
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R982
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740