DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and aldh18a1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_017950890.1	Gene:	aldh18a1 / 550060	XenbaseID:	XB-GENE-5765545	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	441/777 - (56%)
Similarity:	547/777 - (70%)	Gaps:	36/777 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HGPRQPLVSPERRLEKAHPTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAEC 91
            |....|.::.........| |..||:||:|:|:||||||||:||.|..||||||||||||||:..
Frog   129 HWSNIPFITVPHMRSHGKP-FAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVL 192

  Fly    92 HLEGREVMMVTSGAVAFGKQKLAQELLMSLSMRETLNPKDS--KEFDGATLEPRAAAAVGQSGLM 154
            ..:|||:|:|||||||||||:|..|:|:|.|:|:.|:...:  |:.....||.||.||.||||||
Frog   193 QNQGREMMIVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNQLKDMQVPVLEARACAAAGQSGLM 257

  Fly   155 SLYDAMFAQYGVKIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDE 219
            :||:|||.||.:..||:|||..||::|:.|.||..||.||:.:||||||||||||.||     .|
Frog   258 ALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIINTNDAVVPP-----PE 317

  Fly   220 PAGGAR--RGIPIKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSI 282
            |....:  ..|.|||||||:|.||.|::|||:|::|||:|:::.||..|.|||:..:...|..|:
Frog   318 PNSDLQGVNVISIKDNDSLAARLAVEMKADLIIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSV 382

  Fly   283 EFGKKSKVGTGGMDSK-------------------VKAATWALDRGVSVVICNGMQEK----AIK 324
            .||.||:||.|||::|                   ||||.|||..|.||||.||...|    .|.
Frog   383 TFGTKSRVGMGGMEAKPYKARASALCSSISSPPFSVKAALWALQGGTSVVIANGTHPKISGHVIT 447

  Fly   325 TIIGGRKVGTFFTEATESANAVPVEVMAENARTGSRQMQALTPAQRASAVNTLADLLVSREKFIL 389
            .|:.|:||||||:|...:...  ||..||.||||.|.:..|.|.|||..:..|||||....:.||
Frog   448 DIVEGKKVGTFFSEVKPAGPT--VEQQAEMARTGGRSLATLLPEQRAEIIFHLADLLTDHREEIL 510

  Fly   390 DANAKDLAEAQKSG-LAKPLLSRLSLNPAKLKNLSVGLKQIAEDSHKNVGRVLRRTRLADQLELK 453
            .||.||:.||:..| ||.|||.||||:.|||.:||:||:|||..|..:|||||||||:|..|||:
Frog   511 SANKKDMDEAEDKGRLAAPLLKRLSLSTAKLNSLSIGLRQIAASSQDSVGRVLRRTRIAKDLELE 575

  Fly   454 QVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGKEAAHSNKALMELVKEALATVGAEHA 518
            :|||||||||||||||||.||||:|||:||.||||||||||||::|:.|..|.:|||:..|...|
Frog   576 EVTVPIGVLLVIFESRPDCLPQVSALAIASGNGLLLKGGKEAANTNQILYRLTQEALSLHGVRDA 640

  Fly   519 VSLVSTREEISDLLSMENHIDLIIPRGSSDLVRSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKA 583
            |.||:||||:.||..:...||||||||||.|||.||:.:..|||:||:||:||||:|.||.::|.
Frog   641 VQLVNTREEVEDLCRLNKLIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHVYVDSDASVDKV 705

  Fly   584 LRIARDAKCDYPAACNAMETLLIHEDLMSGAIFGDVCNMLKREGVKIYAGPRLNQQLTFGPPAAK 648
            .||.||:||:||||||||||||||.|::...:|..:.:||:.|.|||:||||....|||.|...|
Frog   706 TRIVRDSKCEYPAACNAMETLLIHRDILRTPLFDQIIDMLRVEQVKIHAGPRFASYLTFSPSEVK 770

  Fly   649 SLKHEYGALECCIEVVPSLDEAINHIHTYGSSHTDVIVTENDAAARQFLGSVDSACVFHNASSRF 713
            ||:.|||.||||:|||..:.:||.|||.|||||||.|:|||:..|..||..|||||||.|.|:||
Frog   771 SLRTEYGDLECCLEVVDGVQDAIEHIHKYGSSHTDAIITENEQTAEYFLQHVDSACVFWNTSTRF 835

  Fly   714 ADGFRFGLGAEVGISTARIHARGPVGVEGLLTTKWILEGQDHAAADFAEGGGRTWLHETLPL 775
            :||:||||||||||||||||||||||:||||||||||.|::|..:||:|.|.:.:|||.||:
Frog   836 SDGYRFGLGAEVGISTARIHARGPVGIEGLLTTKWILRGENHVVSDFSEQGSKKYLHEKLPV 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789	165/314 (53%)
		P5CS	50..775	CDD:130164	436/752 (58%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	258/404 (64%)
aldh18a1	XP_017950890.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1223
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2142
Inparanoid	1	1.050	828	1.000	Inparanoid score	I449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D832430at2759
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto104424
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160