DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and Aldh18a1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001101994.1	Gene:	Aldh18a1 / 361755	RGDID:	1311431	Length:	795	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	440/745 - (59%)
Similarity:	549/745 - (73%)	Gaps:	17/745 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LEKAH-PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLEGREVMMVTS 103
            |.:|| ..|..||:||:|:|:||||||||:||.|..||||||||||||||:....:|||:|:|||
  Rat    53 LSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTS 117

  Fly   104 GAVAFGKQKLAQELLMSLSMRETLNPKDS--KEFDGATLEPRAAAAVGQSGLMSLYDAMFAQYGV 166
            ||||||||:|..|:|:|.|:|:.|:...:  ||.....||.||.||.||||||:||:|||.||.:
  Rat   118 GAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSI 182

  Fly   167 KIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDEPAGGAR--RGIP 229
            ..||:|||..||::|:.|.||..||.||:.:|||||:||||||.||.     ||....:  ..|.
  Rat   183 CAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPA-----EPNSDLQGVNVIS 242

  Fly   230 IKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSIEFGKKSKVGTGG 294
            :||||||:|.||.|::.||||::|||:|:::.||..|.|||:..:...|..|:.||.||:||.||
  Rat   243 VKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGG 307

  Fly   295 MDSKVKAATWALDRGVSVVICNGMQEK----AIKTIIGGRKVGTFFTEATESANAVPVEVMAENA 355
            |::|||||.|||..|.||||.||...|    .|..|:.|:||||||:|...:...  ||...|.|
  Rat   308 MEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPT--VEQQGEMA 370

  Fly   356 RTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSLNPAKLK 420
            |:|.|.:..|.|.|||..:|.|||||..:.:.||.||.|||.||: ..||.|||.||||:.:||.
  Rat   371 RSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAE-GRLAGPLLKRLSLSTSKLN 434

  Fly   421 NLSVGLKQIAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASAN 485
            :|::||:|||..|.::|||||||||:|..|||:||||||||||||||||||.||||||||:||.|
  Rat   435 SLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGN 499

  Fly   486 GLLLKGGKEAAHSNKALMELVKEALATVGAEHAVSLVSTREEISDLLSMENHIDLIIPRGSSDLV 550
            ||||||||||.|||:.|..|.:|||:..|.:.|:.||:||||:.||..::..||||||||||.||
  Rat   500 GLLLKGGKEAMHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLV 564

  Fly   551 RSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETLLIHEDLMSGAI 615
            |.||:.:..|||:||:||:||:|:|.:|.::|..|:.||:||:|||||||:||||||.||:...:
  Rat   565 RDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPL 629

  Fly   616 FGDVCNMLKREGVKIYAGPRLNQQLTFGPPAAKSLKHEYGALECCIEVVPSLDEAINHIHTYGSS 680
            |..:.:||:.|.|||:|||:....|||.|...|||:.|||.||.|||||.|:.|||:|||.||||
  Rat   630 FDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSS 694

  Fly   681 HTDVIVTENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLT 745
            |||||||||:..|..||..|||||||.|||:||:||:||||||||||||:|||||||||:|||||
  Rat   695 HTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLT 759

  Fly   746 TKWILEGQDHAAADFAEGGGRTWLHETLPL 775
            |||:|.||||..:||:|.|...:|||.||:
  Rat   760 TKWLLRGQDHVVSDFSEHGRLKYLHENLPV 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789	164/295 (56%)
		P5CS	50..775	CDD:130164	435/732 (59%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	256/403 (64%)
Aldh18a1	NP_001101994.1	AAK_P5CS_ProBA	63..354	CDD:239789	164/295 (56%)
		P5CS	64..792	CDD:130164	436/734 (59%)
		ALDH_F18-19_ProA-GPR	364..767	CDD:143398	256/403 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345231
Domainoid	1	1.000	313	1.000	Domainoid score	I1259
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2142
Inparanoid	1	1.050	825	1.000	Inparanoid score	I438
OMA	1	1.010	-	-		QHG58163
OrthoDB	1	1.010	-	-		D832430at2759
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto97737
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910