DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and pro1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_593164.1	Gene:	pro1 / 2543410	PomBaseID:	SPAC821.11	Length:	451	Species:	Schizosaccharomyces pombe

Alignment Length:	461	Identity:	176/461 - (38%)
Similarity:	272/461 - (59%)	Gaps:	52/461 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VEVMAENARTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDLAEAQ---KSG-LAKPL 408
            :|...:.|:.....:|.|:...|..|::.:.:.|..::..:|.|||:|:..|:   :|| |:..:
pombe     3 LEENVKEAKNAFNILQTLSVEDRDDALDKIVEELRIKKSEVLAANAEDMKAAKLLAESGKLSSSM 67

  Fly   409 LSRLSLNPA-KLKNLSVGLKQIAEDSHKNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDS 472
            :.||.|:.: |..::..|:..: :.....:|||.....|.|.|:|.:|:.|:|:||||||:||:.
pombe    68 VKRLDLSSSDKYDSMVQGVLDV-KSLPDPLGRVTYARSLDDGLDLYKVSCPVGLLLVIFEARPEV 131

  Fly   473 LPQVAALAMASANGLLLKGGKEAAHSNKALMELVKEALA-TVGAEHAVSLVSTREEISDLLSMEN 536
            :..:.:||:.|.|.::||||.|:|.|..||..:|:.||. :...:.||.||.:|||:|.||.::.
pombe   132 IINITSLAIKSGNAVVLKGGTESAKSFAALSNVVRSALGKSKVPQAAVQLVQSREEVSQLLKLDE 196

  Fly   537 HIDLIIPRGSSDLVRSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAM 601
            :|||:|||||::|||.|:..: .|||||||.|:|.:|:..|||:|.|.::..|.|.||||||||:
pombe   197 YIDLVIPRGSTNLVRHIKDNT-KIPVLGHAAGLCSMYVHEDADMELASKLVLDGKTDYPAACNAI 260

  Fly   602 ETLLIHEDLMSGAIFGDVCNMLKREGVKIYAGPRLNQQLT-------FGPPAAKSLKH------- 652
            |||||:|.::|..:                  |::.:.||       ..|.:.|.||.
pombe   261 ETLLINEAVLSSHL------------------PKIAETLTEAKVTLKCDPASLKVLKDMPKVSAL 307

  Fly   653 -----------EYGALECCIEVVPSLDEAINHIHTYGSSHTDVIVTENDAAARQFLGSVDSACVF 706
                       |:..|...|:.||||..|:.||:|:||.|||.|:|.::|||.:|:..:|::.|:
pombe   308 VEPSVDQDYNTEFSDLILAIKTVPSLQSAMQHINTHGSKHTDCIITSSEAAANRFMAGIDASGVY 372

  Fly   707 HNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTTKWILEGQDHAAADFAEG-GGRTWLH 770
            .|||:|||||||:|.|.||||||.:||||||:|::||...|:.|.|....|:.:..| |.|.:.|
pombe   373 WNASTRFADGFRYGYGTEVGISTNKIHARGPMGLDGLTIYKYQLRGNGQVASSYGVGPGKRAFKH 437

  Fly   771 ETLPLD 776
            ..:.:|
pombe   438 TPINID 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789
		P5CS	50..775	CDD:130164	175/458 (38%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	169/434 (39%)
pro1	NP_593164.1	ProA	1..424	CDD:223093	170/440 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	182	1.000	Domainoid score	I793
eggNOG	1	0.900	-	-		E1_COG0014
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I628
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003602
OrthoInspector	1	1.000	-	-		oto101597
orthoMCL	1	0.900	-	-		OOG6_101419
Panther	1	1.100	-	-	LDO	PTHR11063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R982
SonicParanoid	1	1.000	-	-		X2479
TreeFam	1	0.960	-	-
	12	11.850