DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7470 and ALDH3A1

DIOPT Version :9

Sequence 1:	NP_001246877.1	Gene:	CG7470 / 40443	FlyBaseID:	FBgn0037146	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_005256579.1	Gene:	ALDH3A1 / 218	HGNCID:	405	Length:	570	Species:	Homo sapiens

Alignment Length:	342	Identity:	71/342 - (20%)
Similarity:	117/342 - (34%)	Gaps:	96/342 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RPDSLPQVAALAMASANGLLLKGGKEAAHSNKALMELVKEALATVGAEHAVS-----LVSTREEI 528
            ||.|:       .::.|.::||..:        |.|.:...|||:..::...     :.....|.
Human   241 RPGSV-------CSAGNSVVLKPSE--------LSENMASLLATIIPQYLDKDLYPVINGGVPET 290

  Fly   529 SDLLSMENHIDLIIPRGSSDLVRSIQQQSL-HI-PVLGHAEGVCHVYIDRDADLEKALR------ 585
            ::||  :...|.|:..||:.:.:.|...:. |: ||.....|....|:|::.||:.|.|
Human   291 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 353

  Fly   586 --------IARD-AKCDYPAACNAMETL------LIHED---------LMSGAIFGDVCNMLKRE 626
                    :|.| ..||.......:|.|      ...||         ::|...|..|..::  |
Human   354 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI--E 416

  Fly   627 GVKI-----------YAGPRLNQQLTFGPPAAKSLKHEYGALECCIEVVPSLDEAINHIHTYGSS 680
            |.|:           |..|.:   ||...|.:..::.|.......|..|.||:|||..|:.....
Human   417 GQKVAYGGTGDAATRYIAPTI---LTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKP 478

  Fly   681 HTDVIVTENDAAARQFLGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHAR--GPVGVEGL 743
            ....:.:.||...::.:....|.                |:.|...|....:|:.  |.||..|:
Human   479 LALYMFSSNDKVIKKMIAETSSG----------------GVAANDVIVHITLHSLPFGGVGNSGM 527

  Fly   744 LTTKWILEGQDHAAADF 760
                    |..|....|
Human   528 --------GSYHGKKSF 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7470	NP_001246877.1	AAK_P5CS_ProBA	49..337	CDD:239789
		P5CS	50..775	CDD:130164	71/342 (21%)
		ALDH_F18-19_ProA-GPR	349..753	CDD:143398	68/333 (20%)
ALDH3A1	XP_005256579.1	ALDH-SF	<248..564	CDD:299846	68/328 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910